Individual research recommendation details

Recommendation ID

NG191/12

Question

In people with suspected COVID-19-associated pulmonary aspergillosis (CAPA), what are the most accurate tests for diagnosing the infection and when should they be done?

Any explanatory notes
(if applicable)

Population: adults, young people and children who are critically ill and have, or have had, COVID-19 as part of their acute illness, and suspected CAPA. Subgroups of particular interest include young people and children, and pregnant women.

Diagnostic tests:
• any methods used to diagnose pulmonary aspergillosis (for example, CT imaging, testing of bronchoalveolar lavage, non-bronchoscopic lavage, endotracheal aspirate, sputum samples, serum assays)

Reference standard:
• lung biopsy or postmortem diagnosis

Target condition:
• CAPA

Outcomes:
• sensitivity and specificity
• positive and negative likelihood ratios

Analysis:
• optimal time of diagnostic testing

Source guidance details

Comes from guidance

COVID-19 rapid guideline: managing COVID-19

Number

NG191

Date issued

March 2021

Other details