Overview
Evidence-based recommendations on idelalisib (Zydelig) for treating chronic lymphocytic leukaemia in adults.
September 2016: The European Medicines Agency has reviewed idelalisib and the marketing authorisation has been updated.
For people taking idelalisib as a first therapy, the marketing authorisation now states that idelalisib is for ‘first-line treatment in the presence of 17p deletion or TP53 mutation in patients who are not eligible for any other therapies’.
Additional information about infections has been included in the marketing authorisation.
Last reviewed: 28 September 2018
We checked this guidance and found nothing new that affects the recommendations. For more information, see the review decision.
Next review: This guidance will be reviewed if there is new evidence that is likely to change the recommendations.
Guidance development process
How we develop NICE technology appraisal guidance
We reviewed the evidence in September 2018. We found nothing new that affects the recommendations in this guidance.
Your responsibility
The recommendations in this guidance represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, health professionals are expected to take this guidance fully into account, alongside the individual needs, preferences and values of their patients. The application of the recommendations in this guidance is at the discretion of health professionals and their individual patients and do not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.
All problems (adverse events) related to a medicine or medical device used for treatment or in a procedure should be reported to the Medicines and Healthcare products Regulatory Agency using the Yellow Card Scheme.
Commissioners and/or providers have a responsibility to provide the funding required to enable the guidance to be applied when individual health professionals and their patients wish to use it, in accordance with the NHS Constitution. They should do so in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities.
Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible.