Dimethyl fumarate for treating relapsing‑remitting multiple sclerosis

Dimethyl fumarate is recommended as an option for treating adults with active relapsing‑remitting multiple sclerosis (normally defined as 2 clinically significant relapses in the previous 2 years), only if:

• they do not have highly active or rapidly evolving severe relapsing‑remitting multiple sclerosis and

• the manufacturer provides dimethyl fumarate with the discount agreed in the patient access scheme.

People currently receiving treatment initiated within the NHS with dimethyl fumarate that is not recommended for them by NICE in this guidance should be able to continue treatment until they and their NHS clinician consider it appropriate to stop.