Search strategy

Advice

Database: Medline, Version: Ovid MEDLINE(R) without Revisions <1996 to October Week 3 2016

Search date: 31 Oct 2016

1 pitolisant/ (0)

2 (wakix or pitolisant or tiprolisant).mp. (25)

3 ("BF2.649" or BF2649).tw. (14)

4 1 or 2 or 3 (31)

5 randomized controlled trial.pt. (326071)

6 randomized controlled trial/ (326071)

7 controlled clinical trial.pt. (45571)

8 random allocation/ (53154)

9 Placebos/ (15215)

10 clinical trial, phase ii/ or clinical trial, phase iii/ (34048)

11 5 or 6 or 7 or 8 or 9 or 10 (445020)

12 animals/ (3182882)

13 humans/ (9075526)

14 12 not 13 (2049165)

15 11 not 14 (395896)

16 4 and 15 (4)

Database: Medline in-process, Version: Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) <1946 to Present

Search date: 31 Oct 2016

1 (wakix or pitolisant or tiprolisant).mp. (41)

2 ("BF2.649" or BF2649).tw. (16)

3 1 or 2 (47)

4 narcoleps*.mp. or sleep*.tw. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] (139373)

5 3 and 4 (25)

6 3 not 5 (22)

Database: Embase, Version: Ovid Embase <1996 to 2016 October 28>

Search date: 31 Oct 16

1 pitolisant/ (121)

2 (wakix or pitolisant or tiprolisant).mp. (136)

3 ("BF2.649" or BF2649).tw. (22)

4 1 or 2 or 3 (140)

5 *randomized controlled trial/ (37393)

6 *Randomization/ (1552)

7 *Placebo/ (24243)

8 *Crossover Procedure/ (3691)

9 (random or randomi* or randoml*).tw. (1007657)

10 rct*.tw. (43260)

11 (phase 4 or phase iv or phase 3 or phase iii).tw. (63910)

12 placebo*.tw. (197827)

13 (crossover* or (cross adj over*)).tw. (64591)

14 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 (1128664)

15 Nonhuman/ (3576468)

16 Human/ (12824354)

17 15 not (15 and 16) (2416322)

18 14 not 17 (1041943)

19 4 and 18 (24)

20 limit 19 to conference abstract (7)

21 19 not 20 (17)

Databases: Cochrane/CRD databases, Version: Wiley

Search date: 31 Oct 16

1 wakix or pitolisant or tiprolisant:ti,ab,kw (Word variations have been searched) 8

#2 "BF2.649" or BF2649:ti,ab,kw 4

#3 #1 or #2 8