Table 1 Abbreviations

Abbreviation	Definition
AMP	Amputee Mobility Predictor
BAP	Bone-anchored prosthesis
BMD	Bone-mineral density
CI	Confidence interval
DSF	Direct skeletal fixation
DXA	Dual X-ray absorptiometry
EMG	Electromyography
EQ-5D	EuroQol 5-dimension quality of life questionnaire
HTA	Health Technology Assessment
HRQOL	Health-related quality of life
ILP/EEFP/EEP	Integral Leg Prosthesis; also known as ESKA Endo-Exo Femur-Prosthesis
ITAP	Intraosseous Transcutaneous Amputation Prosthesis
MCS	Mental component summary
NS	Not significant
OFI-C	Curved osseointegration femur implant
OFI-Y	Gamma osseointegration femur implant
OIP	Osseointegration prosthesis
OPRA	Osseointegrated Prosthesis for the Rehabilitation of Amputees
OGA-OPL	Osseointegration Group of Australia-Osseointegration Prosthetic Limb
OTI	Osseointegration tibia implant
PMQ	Prosthesis mobility questionnaire
POP	Percutaneous osseointegrated prosthesis
PRO	Patient-reported outcome
PROM	Patient-reported outcome measure
PWS	Preferred walking speed
PCS	Physical component summary
QOL	Quality of life
Q-TFA	Questionnaire for persons with a Transfemoral Amputation
ROM	Range of motion
RSA	Radio stereometric analysis
RCT	Randomised controlled trial
SF-36	36-Item Short-Form Health Survey
SF-6D	Short-Form 6-Dimension
SD	Standard deviation
TFA	Transfemoral amputation
TKR	Total knee replacement
TOFA	Transcutaneous osseointegration for amputees
TOPS	Transcutaneous osseointegrated prosthetic systems
TTA	Trans-tibial amputation
THA	Trans-humeral amputation
TRA	Transradial amputation
TUG	Timed Up and Go
6MWT	6-minute walk test

Interventional procedure overview of direct skeletal fixation of limb prostheses using an intraosseous transcutaneous implant