2 The diagnostic tests

Clinical need and practice

ADHD

2.1

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental condition characterised by a persistent pattern of hyperactivity, impulsivity, and inattention that interferes with daily and occupational functioning.

2.2

This may manifest as: wandering off-task; having difficulty sustaining focus; being disorganised; excessive motor activity when it is not appropriate; excessive fidgeting, tapping and talkativeness; social intrusiveness; and making important decisions without considering the long-term consequences. People with ADHD may take hasty actions that occur in the moment without forethought and that have high potential for harm to the individual.

2.3

The global prevalence of ADHD in children is estimated to be around 5%. In the UK, the prevalence of ADHD in adults is estimated at 3% to 4%. It is more commonly diagnosed in boys than girls.

2.4

ADHD is associated with psychiatric disorders including oppositional defiant disorder, conduct disorder, substance misuse, and mood disorders such as depression and mania. Autism spectrum disorder, dyslexia, dyscalculia, and dyspraxia commonly co-occur in people with ADHD. Overall prognosis may depend on the severity and management of any comorbid disorders.

2.5

Treatment for ADHD may be non-pharmacological, including psychoeducation, ADHD coaching, parent training, or environmental changes. Pharmacological treatment may include stimulant or non-stimulant medication. Medication doses are titrated against symptoms and adverse effects until dose optimisation is achieved.

Care pathway and clinical need

2.7

A clinical assessment for ADHD by a specialist healthcare professional involves gathering information about a person's symptoms and behaviours. This includes the person's developmental, medical, educational and mental health history, and ADHD-specific history. Information may come from the person themselves, a parent or carer, schoolteachers (for children), or employers (for adults). Information can be collected using interviews, observer reports and standardised rating scales.

2.8

Standard clinical assessment for ADHD is based on diagnostic criteria that require training and experience to apply correctly and require clinical judgement, relying on information obtained from a range of sources. Information from these sources may often be incomplete or contradictory, requiring multiple clinic visits or observations to reach a diagnostic decision. Diagnosis of ADHD is further complicated by similarities in presentation and overlap with other neurodevelopmental disorders and mental health conditions, which may lead to difficulties and delays in decision making.

2.9

Digital technologies that combine measures of cognition and motor (physical) activity may help healthcare professionals when considering a diagnosis of ADHD, by providing additional objective information. This could reduce the number or length of clinical appointments needed to reach a diagnosis, reducing patient waiting lists and freeing up NHS resources. It may also provide people with quicker access to appropriate further care or assessment.

The interventions

2.10

The intervention is any of the digital technologies that combine measures of cognition and motor activity listed in table 1, when used as part of the standard clinical assessment for ADHD by a healthcare professional. See section 1.3 of the external assessment report for further information on the technologies. The tests may not be suitable for everyone.

Table 1 Technology specifications
Technology Technology description Test cost

EFSim Test,

EFSim Test Web Version

(Peili Vision Oy)

A game-like virtual reality (VR) test suitable for people aged 8 to 16 years.

The simulation includes a home-like environment where the user performs everyday life tasks. Neurological performance measures, and head and hand movement are compared to data from a typically developing population to identify deficits in executive function associated with ADHD.

There is a web version of the EFSim Test that does not need a VR headset. It is designed for remote testing that can be done without a healthcare professional present.

Proposed delivery model in which a dedicated healthcare professional travels to each practice 1 day per month to provide assessments. Cost per 7.5‑hour working day of £197.05 including VAT.

Nesplora Attention Kids Aula

Nesplora Attention Adults Aquarium

(Giunti Nesplora)

VR continuous performance test suitable for people aged 6 to 16 years (Kids Aula) and 17 to 90 years (Aquarium). It measures auditory and visual attention, impulsivity, motor activity and reaction time in a real-life setting. It provides a score calculated by comparing to a normative data set of people without ADHD of the same sex and age.

£21.03 single use (plus a one-off registration fee of £84.12), £75.70 for 7 uses (monthly), £227.11 for 22 uses (quarterly) or £1,345.85 per year for unlimited use. Costs exclude VAT.

QbCheck

(QbTech)

Web-based continuous performance test with a webcam motion-tracking system suitable for people aged 6 to 60 years. Measures 3 core symptoms of ADHD: attention, impulsivity, and hyperactivity. Results from the test are compared to a normative data set of people without ADHD of the same sex and age. It is designed for remote testing that can be done without a healthcare professional present.

£69 per test excluding VAT.

QbTest

(QbTech)

Continuous performance test with a high-resolution infrared motion-tracking system suitable for people aged 6 to 60 years. There are 2 versions for different age groups. They vary in the computer-based task. Measures 3 core symptoms of ADHD: attention, impulsivity, and hyperactivity. Results from the test are compared to a normative data set of people without ADHD of the same sex and age.

£31.20 per test excluding VAT.

The comparator

2.11

The comparator is standard clinical assessment by a healthcare professional without using digital technologies that measure cognition and motor activity. This assessment uses a variety of information sources, including a developmental and psychiatric history, psychosocial assessment, and observer reports.