The aim of this procedure is to prevent or postpone disease progression, and reduce the need for surgical intervention. The mechanism of action of radiation therapy is uncertain, but it is thought to affect the development and growth rate of fibroblasts in the palmar fascia.
Radiation therapy is delivered to the nodules and cords that have formed in the hands. The usual regimen is 30 Gy in 10 fractions, consisting of 2 phases of 15 Gy in 5 fractions with a gap of 6–12 weeks between the 2 phases. Alternatively, 21 Gy may be given in 7 fractions on alternate days over 2 weeks.