Laser lithotripsy for difficult-to-treat bile duct stones

NICE did a rapid review of the published literature on the efficacy and safety of this procedure. This comprised a comprehensive literature search and detailed review of the evidence from 13 sources, which was discussed by the committee. The evidence included 1 systematic review, 2 systematic reviews and meta-analyses, 5 randomised controlled trials, 4 non-randomised comparative studies and 1 case series (registry). It is presented in the summary of key evidence section in the interventional procedures overview. Other relevant literature is in the appendix of the overview.

The professional experts and the committee considered the key efficacy outcomes to be: stone removal, reduction in symptoms and relief of biliary obstruction.

The professional experts and the committee considered the key safety outcomes to be: cholangitis, bile duct damage including perforation and stricture, pancreatitis, bleeding and the need for surgery.

Patient commentary was sought but none was received.

The committee was informed that the technique is evolving and different techniques may have different efficacy and safety profiles.

The committee encourages the establishment of a registry for this procedure.