Guidance
Recommendations for research
Recommendations for research
As part of the 2024 update, the guideline committee made a new recommendation for research (marked [2024]). Recommendations for research retained from previous updates are labelled [2019] and [2013].
Key recommendations for research
1 Risk factor-based screening tool for adults having iodine-based contrast media
What validated risk assessment tools could be used to predict the occurrence of contrast-associated acute kidney injury following the administration of intravenous iodine-based contrast media? [2024]
For a short explanation of why the committee made this recommendation for research, see the rationale section on assessing risk factors in adults having iodine-based contrast media.
Full details of the evidence and the committee's discussion are in evidence review B: risk prediction tools and eGFR for the prediction of iodine-based contrast media-associated acute kidney injury.
2 Risk stratification for contrast-induced acute kidney injury
Can risk of contrast-induced acute kidney injury be stratified by eGFR thresholds? [2019]
For a short explanation of why the committee made this recommendation for research, see the rationale section on preventing acute kidney injury in adults having iodine-based contrast media.
Full details of the evidence and the committee's discussion are in evidence review A: preventing contrast-induced acute kidney injury.
3 Different oral fluids and oral fluid regimens
What is the relative effectiveness and cost effectiveness of different oral fluids and different oral fluid regimens, both with and without oral N-acetylcysteine, at preventing contrast-induced acute kidney injury? [2019]
For a short explanation of why the committee made this recommendation for research, see the rationale section on preventing acute kidney injury in adults having iodine-based contrast media.
Full details of the evidence and the committee's discussion are in evidence review A: preventing contrast-induced acute kidney injury.
4 Long-term outcomes of acute kidney injury
What are the long-term outcomes of acute kidney injury in adults, children and young people? [2013]
5 Rapid referral to nephrology services for moderate to severe acute kidney injury
What is the clinical and cost effectiveness of rapid referral (within 12 hours) to nephrology services for adults with moderate to severe (stage 2 to 3) acute kidney injury not needing critical care? [2013]
6 Definition of acute kidney injury – system for staging and detection
Can a simplified definition and staging system, based on Système International (SI) units, be used to predict short- to medium-term outcomes in acute kidney injury? [2013]
Other recommendations for research
7 Introducing renal replacement therapy
What is the clinical and cost effectiveness of early versus later introduction of renal replacement therapy in patients with acute kidney injury stages 2 and 3, when there is no urgent need for therapy? [2013]
8 Preventing deterioration
What is the clinical and cost effectiveness of continuing ACE inhibitor or ARB treatment, versus stopping treatment 24 hours before cardiac surgery and resuming 24 hours after, in people with chronic kidney disease and an eGFR of less than 30 ml/min/1.73m2? [2013]