10 Staging systems

**Table 1 Rai staging definitions**
Rai	Characteristics	Median survival
Stage 0	Lymphocytosis in blood and bone marrow only	12 years
Stage I	Lymphocytosis plus lymphadenopathy	7 years
Stage II	Lymphocytosis plus splenomegaly or hepatomegaly	7 years
Stage III	Lymphocytosis plus anaemia (Hb less than 110 g/L)	Less than 1 year
Stage IV	Lymphocytosis plus thrombocytopenia (platelets less than 100 x 109/L)	Less than 1 year

**Table 2 Binet staging definitions**
Binet	Characteristics	Median survival
Stage A	Less than 3 sites involved, Hb more than 100 g/L, platelets more than 100 x 10⁹/L	9 years
Stage B	More than 3 sites involved, Hb more than 100 g/L, platelets more than 100 x 10⁹/L	5 years
Stage C	Hb less than 100 g/L, platelets more than 100 x 10⁹/L	2 years

Note: Involved sites for binet are liver, spleen and lymph nodes in inguinal, axilliary and cervical regions.

ISBN: 978-1-4731-5672-2