The recommended dosage of tofacitinib for induction is 10 mg taken orally twice daily for 8 weeks, then 5 mg taken twice daily for maintenance. If adequate therapeutic benefit is not achieved by week 8 the induction dose can be taken for an additional 8 weeks (16 weeks in total). Induction therapy should be stopped if there is no evidence of therapeutic benefit by week 16.
For patients whose disease has responded inadequately to tumour necrosis factor antagonist therapy, consider continuing the 10-mg twice-daily dose for maintenance in order to maintain therapeutic benefit. If response decreases to tofacitinib 5 mg taken twice daily as maintenance therapy, consider increasing the dose to 10 mg taken twice daily.
When the disease has responded adequately to tofacitinib, corticosteroids may be reduced or stopped in accordance with standard care.