There are different 5-FU regimens, in which the drug is given either by intravenous infusion or bolus injection. There is considerable variability in current UK practice because of a lack of consensus over the optimum regimen. Although the rates obtained in individual trials have shown variation, there is some evidence to suggest that infusional regimens, for example the Lockich and de Gramont, may be more effective in terms of progression-free survival, tumour response, safety, toxicity and quality of life than bolus regimens, for example the Mayo. However, infusional regimens are more complex to administer and the use of central venous lines increases the rate of complications, such as infection and thrombosis.