Most people in the chronic phase who are not suitable candidates for SCT are offered IFN-alfa, which is regarded as superior to conventional chemotherapeutic agents in improving survival. However, 15% to 25% of people with CML discontinue IFN-alfa therapy because of intolerable side effects. The immediate side effects of IFN-alfa include fever, chills and anorexia; more serious chronic side effects are fatigue, depression, insomnia, weight loss, peripheral neuropathy, alopecia, stomatitis, diarrhoea and short-term memory loss. For those who are intolerant of IFN-alfa, or in whom IFN-alfa treatment has failed, imatinib is the treatment of choice, in line with the previous NICE technology appraisal guidance on imanitib for chronic myeloid leukaemia.