5.1
The trial literature is dominated by comparisons of differing frequency of use of fluticasone propionate (4 trials) and comparisons of mometasone furoate with more traditional twice-daily treatment options (3 trials).
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Trials are needed to establish whether once-daily use of the older (twice-daily) products is equivalent to more frequent use.
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Trials are also required to establish whether once-daily use of the older twice-daily products is equivalent to the once-daily-only products.
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Trials are required for all the potency classes, in particular for mild potency preparations, because no trials examining frequency of application of topical corticosteroids exist for this group.