Research recommendation(s) from an individual piece of guidance Guidance: EGFR‑TK mutation testing in adults with locally advanced or metastatic non-small-cell lung cancer Date issued: 14 August 2013 Research recommendations coming out of this guidance NICE recommends that studies directly comparing different epidermal growth factor receptor tyrosine kinase (EGFR-TK) mutation test methods are performed. These studies should include the re-testing of stored non-small-cell lung cancer (NSCLC) tumour samples using different EGFR-TK mutation test methods and should link to patient outcomes.