Suggested remit: To appraise the clinical and cost effectiveness of spesolimab within its marketing authorisation for treating generalised pustular psoriasis flares in adults.
 
Status In progress
Technology type Medicine
Decision Selected
Process STA Standard
ID number 3963

Provisional Schedule

Expected publication 19 March 2025

Project Team

Project lead Jeremy Powell

Email enquiries

External Assessment Group Southampton Health Technology Assessment Centre (SHTAC), University of Southampton

Stakeholders

Companies sponsors Boehringer Ingelheim Ltd (spesolimab)
Others Department of Health and Social Care
  NHS England
Patient carer groups Psoriasis and Psoriatic Arthritis Alliance
  Psoriasis Association
Professional groups British Association of Dermatologists
  Royal College of Physicians
Comparator companies AbbVie (adalimumab, risankizumab)(CAU signed - participating)
  Accord Healthcare (methotrexate)(CAU not signed - not participating)
  Advanz Pharma (methotrexate)(CAU not signed - not participating)
  Almirall (dimethyl fumarate, tildrakizumab)(CAU not signed - not participating)
  Amgen (adalimumab, apremilast)(CAU not signed - not participating)
  Aspire Pharma (dimethyl fumarate)(CAU not signed - not participating)
  Biogen Idec (adalimumab, dimethyl fumarate, etanercept, infliximab)(CAU not signed - not participating)
  Bristol Myers Squibb (deucravacitinib)(CAU not signed - not participating)
  B&S Colorama (ciclosporin)(CAU not signed - not participating)
  Celltrion Healthcare UK (adalimumab, infliximab)(CAU not signed - not participating)
  Celix Pharma (dimethyl fumarate)(CAU not signed - not participating)
  Dexcel-Pharma (ciclosporin)(CAU not signed - not participating)
  Eli Lilly and Company (ixekizumab)(CAU not signed - not participating)
  Fresenius Kabi (adalimumab)(CAU not signed - not participating)
  Genus Pharmaceuticals (acitretin, dimethyl fumarate)(CAU not signed - not participating)
  Hospira UK (methotrexate)(CAU not signed - not participating)
  Johnson & Johnson Innovative Medicine (guselkumab, ustekinumab) (CAU signed - participating)
  Leo Pharma (brodalumab) (CAU not signed - not participating)
  Medac GmbH (methotrexate)(CAU not signed - not participating)
  Merck Sharp & Dohme (infliximab)(CAU signed - participating)
  Morningside Healthcare (acitretin, ciclosporin, methotrexate)(CAU not signed - not participating)
  Mylan (ciclosporin, dimethyl fumarate)(CAU not signed - not participating)
  Nordic Pharma (methotrexate)(CAU not signed - not participating)
  Novartis Pharmaceuticals UK (ciclosporin, secukinumab) (CAU signed - participating)
  Orion Pharma (UK) (methotrexate)(CAU not signed - not participating)
  Pfizer (etanercept, infliximab, methotrexate)(CAU not signed - not participating)
  Rosemont Pharmaceuticals (methotrexate)(CAU not signed - not participating)
  Sandoz (adalimumab, etanercept, infliximab, methotrexate)(CAU not signed - not participating)
  Santen UK (ciclosporin)(CAU not signed - not participating)
  Teva UK (acitretin, ciclosporin, methotrexate)(CAU not signed - not participating)
  Therakind Limited (methotrexate)(CAU not signed - not participating)
  UCB Pharma (bimekizumab, certolizumab pegol)(CAU signed - participating)
  Viatris (ciclosporin)(CAU not signed - not participating)
  Wockhardt (dimethyl fumarate)(CAU not signed - not participating)
  Zentiva (dimethyl fumarate) (CAU not signed - not participating)
General commentators All Wales Therapeutics and Toxicology Centre
  British National Formulary
  Department of Health - Northern Ireland
  Healthcare Improvement Scotland
  Medicines and Healthcare products Regulatory Agency
  Scottish Medicines Consortium
  Welsh Government
  Welsh Health Specialised Services Committee

Timeline

Key events during the development of the guidance:

Date Update
12 December 2024 Committee meeting: 1
19 June 2024 Invitation to participate
16 March 2023 We had previously said that this appraisal was expected to start in approximately early-February 2023. The company have asked NICE to delay the appraisal. The appraisal will therefore be rescheduled and an update on the revised timelines will be provided when further information is available.
26 October 2022 (10:00) Scoping workshop
07 September 2022 - 05 October 2022 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators
07 September 2022 In progress. Scoping commencing

For further information on our processes and methods, please see our CHTE processes and methods manual