Suggested remit: To appraise the clinical and cost effectiveness of cladribine within its marketing authorisation for treating relapsing multiple sclerosis.
 
 
Status In progress
Technology type Medicine
Decision Selected
Reason for decision Anticipate the topic will be of importance to patients, carers, professionals, commissioners and the health of the public to ensure clinical benefit is realised, inequalities in use addressed, and help them make the best use of NHS resources
Process STA Standard
ID number 6263

Provisional Schedule

Draft guidance 06 December 2024 - 09 January 2025
Committee meeting: 2 05 February 2025
Expected publication 23 April 2025

Project Team

Project lead Kate Moore

Email enquiries

External Assessment Group Warwick Evidence, Warwick Medical School, University of Warwick

Stakeholders

Companies sponsors Merck Group
  Department of Health and Social Care
  Health Technology Wales
  NHS England
Patient carer groups Multiple Sclerosis Trust
  Multiple Sclerosis Society
Professional groups Association of British Neurologists
  Royal College of Physicians
Associated public health groups Public Health Wales
  UK Health Security Agency
Comparator companies Almirall (dimethyl fumarate) (not participating)
  Axunio Pharma (teriflunomide) (not participating)
  Bayer (interferon beta 1-b) (not participating)
  Biogen Idec (dimethyl fumarate, interferon beta-1a, peginterferon beta-1a, diroximel fumarate)
  Celix Pharma (dimethyl fumarate) (not participating)
  Dr. Reddy’s Laboratories (teriflunomide) (not participating)
  Johnson & Johnson Innovative Medicine (ponesimod)
  Merck (interferon beta-1a) (not participating)
  Mylan (dimethyl fumarate, glatiramer acetate, teriflunomide) (not participating)
  Novartis (interferon beta-1b, ofatumumab, siponimod)
  Roche (ocrelizumab) (not participating)
  Sandoz (teriflunomide)
  Sanofi Genzyme (teriflunomide)
  Teva UK (glatiramer acetate) (not participating)
  Zentiva (dimethyl fumarate) (not participating)
General commentators All Wales Therapeutics and Toxicology Centre
  British National Formulary
  Department of Health, Social Services and Public Safety for Northern Ireland
  Healthcare Improvement Scotland
  Medicines and Healthcare products Regulatory Agency
  Scottish Medicines Consortium
  Welsh Government
  Welsh Health Specialised Services Committee

Timeline

Key events during the development of the guidance:

Date Update
13 November 2024 Committee meeting: 1
22 April 2024 Invitation to participate
19 September 2023 - 17 October 2023 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators: 6263
03 August 2023 In progress. DHSC referral received
03 March 2023 Awaiting development. Status change linked to Topic Selection Decision being set to Selected

For further information on our processes and methods, please see our CHTE processes and methods manual