Suggested remit: To appraise the clinical and cost effectiveness of osimertinib with pemetrexed and platinum-based chemotherapy within its marketing authorisation for treating untreated EGFR mutation-positive advanced non-small-cell lung cancer.
 
Status In progress
Technology type Medicine
Decision Selected
Reason for decision Anticipate the topic will be of importance to patients, carers, professionals, commissioners and the health of the public to ensure clinical benefit is realised, inequalities in use addressed, and help them make the best use of NHS resources
Further information Awaiting development
Process STA Standard
ID number 6328

Provisional Schedule

Committee meeting 15 January 2025

Project Team

Project lead Leena Issa

Email enquiries

External Assessment Group Bristol Technology Assessment Group, University of Bristol

Stakeholders

Companies sponsors AstraZeneca (osimertinib)
Others Department of Health and Social Care
  NHS England
Patient carer groups EGFR Positive UK
  Roy Castle Lung Cancer Foundation
Professional groups Association of Cancer Physicians
  British Thoracic Oncology Group
  Royal College of Physicians
  Royal College of Radiologists
Associated guideline groups None
Comparator companies Amarox (erlotinib) (confidentiality agreement not signed, not participating)
  AstraZeneca (gefitinib, osimertinib) (confidentiality agreement not signed, not participating)
  Boehringer Ingelheim (afatinib) (confidentiality agreement not signed, not participating)
  Cipla EU (gefitinib) (confidentiality agreement not signed, not participating)
  Genus Pharmaceuticals (gefitinib) (confidentiality agreement not signed, not participating)
  Glenmark Pharmaceuticals (erlotinib) (confidentiality agreement not signed, not participating)
  Mylan (erlotinib) (confidentiality agreement not signed, not participating)
  Pfizer (dacomitinib) (confidentiality agreement not signed, not participating)
  Roche (erlotinib) (confidentiality agreement not signed, not participating)
  Sandoz (erlotinib, gefitinib) (confidentiality agreement not signed, not participating)
  Zentiva (erlotinib) (confidentiality agreement not signed, not participating)
  Other relevant companies
  Aspire Pharma (pemetrexed) (confidentiality agreement not signed, not participating)
  Dr Reddy’s Laboratories (pemetrexed) (confidentiality agreement not signed, not participating)
  Eli Lilly (pemetrexed) (confidentiality agreement not signed, not participating)
  Genus Pharmaceuticals (pemetrexed) (confidentiality agreement not signed, not participating)
  Pfizer (carboplatin, cisplatin, pemetrexed) (confidentiality agreement not signed, not participating)
  Sandoz (cisplatin, pemetrexed) (confidentiality agreement not signed, not participating)
  Seacross Pharmaceuticals (pemetrexed) (confidentiality agreement not signed, not participating)
  Sun Pharma (pemetrexed) (confidentiality agreement not signed, not participating)
  Zentiva (pemetrexed) (confidentiality agreement not signed, not participating)
General commentators All Wales Therapeutics and Toxicology Centre
  British National Formulary
  Department of Health, Social Services and Public Safety for Northern Ireland
  Healthcare Improvement Scotland
  Medicines and Healthcare products Regulatory Agency
  Scottish Medicines Consortium
  Welsh Government
  Welsh Health Specialised Services Committee
Relevant research groups Institute of Cancer Research

Timeline

Key events during the development of the guidance:

Date Update
30 October 2024 - 20 November 2024 Draft guidance
03 October 2024 Committee meeting
03 October 2024 Declaration of interests
05 March 2024 Invitation to participate
11 October 2023 - 08 November 2023 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators: 6328
11 October 2023 In progress. Scoping commencing
06 September 2023 Awaiting development
06 September 2023 Please note that following on from a request received from the company, the timelines for this appraisal have been revised and the appraisal is now anticipated to begin in early March 2024. These timings are based on a request from the company to reschedule the initial date set by NICE, in order to facilitate a suitably comprehensive and robust submission.

For further information on our processes and methods, please see our CHTE processes and methods manual