Suggested remit: To appraise the clinical and cost effectiveness of adagrasib within its marketing authorisation for treating KRAS G12C mutation positive advanced NSCLC which has been previously treated, or is not suitable for treatment, with platinum based chemotherapy and/or anti-PD-1/PD-L1 immunotherapy.
 
Status In progress
Technology type Medicine
Decision Awaiting decision
Process STA Standard
ID number 6339

Provisional Schedule

Committee meeting 10 April 2025
Expected publication 02 July 2025

Project Team

Project lead Kate Moore

Email enquiries

External Assessment Group Centre for Reviews and Dissemination and Centre for Health Economics, University of York

Stakeholders

Companies sponsors Bristol Myers-Squibb (adagrasib)
Others Department of Health and Social Care
  NHS England
Patient carer groups Roy Castle Lung Cancer Foundation
Professional groups Association of Cancer Physicians
  Association of Respiratory Nurse Specialists
  British Thoracic Oncology Group
  Royal College of Physicians
  Royal College of Radiologists
General commentators All Wales Therapeutics and Toxicology Centre
  British National Formulary
  Department of Health - Northern Ireland
  Healthcare Improvement Scotland
  Medicines and Healthcare products Regulatory Agency
  Scottish Medicines Consortium
  Welsh Government
  Welsh Health Specialised Services
Relevant research groups Institute of Cancer Research
  National Institute for Health & Care Research

Timeline

Key events during the development of the guidance:

Date Update
06 September 2024 Invitation to participate
09 July 2024 - 06 August 2024 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators: 6339
09 July 2024 In progress. Scoping commenced.
19 October 2023 Awaiting development. Status change linked to Topic Selection Decision being set to Selected
26 June 2023 Topic selection

For further information on our processes and methods, please see our CHTE processes and methods manual