Suggested remit: To appraise the clinical and cost effectiveness of pembrolizumab with platinum-based chemotherapy then maintenance pembrolizumab within its marketing authorisation for the treatment of advanced or recurrent endometrial cancer.
 
Status In progress
Technology type Medicine
Decision Awaiting decision
Process STA Standard
ID number 6381

Provisional Schedule

Committee meeting: 1 04 February 2025
Expected publication 16 April 2025

Project Team

Project lead Jeremy Powell

Email enquiries

External Assessment Group Warwick Evidence, Warwick Medical School, University of Warwick

Stakeholders

Companies sponsors Merck Sharp & Dohme (pembrolizumab)
Others Department of Health and Social Care
  NHS England
Patient carer groups Peaches Womb Cancer Trust
Professional groups Association of Anaesthetists
  Cancer Research UK
  Royal College of Physicians
  Royal College of Radiologists
Comparator companies Accord (carboplatin, paclitaxel, cisplatin, doxorubicin) CAU not signed (not participating)
  Alliance Healthcare (cyclophosphamide, paclitaxel) CAU not signed (not participating)
  Bausch & Lomb (megestrol acetate) CAU not signed (not participating)
  Baxter Healthcare (cyclophosphamide) CAU not signed (not participating)
  Bristol Myers Squibb Pharmaceuticals (paclitaxel) CAU not signed (not participating)
  Consilient Health (carboplatin) CAU not signed (not participating)
  Fresenius Kabi (carboplatin, paclitaxel) CAU not signed (not participating)
  Hospira UK (carboplatin, paclitaxel) CAU not signed (not participating)
  Johnson & Johnson Innovative Medicine (doxorubicin) CAU not signed (not participating)
  Medac GmbH (doxorubicin) CAU not signed (not participating)
  Novartis (cisplatin, cyclophosphamide) CAU not signed (not participating)
  Pfizer (carboplatin, paclitaxel, cisplatin, doxorubicin, medroxyprogesterone acetate) CAU not signed (not participating)
  Sandoz (cyclophosphamide) CAU not signed (not participating)
  Seacross Pharmaceuticals (paclitaxel, doxorubicin) CAU not signed (not participating)
  Teva UK (carboplatin, paclitaxel) CAU not signed (not participating)
General commentators All Wales Therapeutics and Toxicology Centre
  British National Formulary
  Department of Health - Northern Ireland
  Healthcare Improvement Scotland
  Medicines and Healthcare products Regulatory Agency
  Scottish Medicines Consortium
  Welsh Government
  Welsh Health Specialised Services Committee
Relevant research groups Institute of Cancer Research

Timeline

Key events during the development of the guidance:

Date Update
08 July 2024 Invitation to participate
20 May 2024 - 18 June 2024 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators: 6381
20 May 2024 In progress. Scoping commencing
24 November 2023 Awaiting development. Status change linked to Topic Selection Decision being set to Selected
24 November 2023 Topic selection

For further information on our processes and methods, please see our CHTE processes and methods manual