Suggested remit: To appraise the clinical and cost effectiveness of obecabtagene autoleucel within its marketing authorisation for treating relapsed or refractory B-cell acute lymphoblastic leukaemia.
 
Status In progress
Technology type Medicine
Decision Selected
Reason for decision Anticipate the topic will be of importance to patients, carers, professionals, commissioners and the health of the public to ensure clinical benefit is realised, inequalities in use addressed, and help them make the best use of NHS resources
Process STA Standard
ID number 6347

Provisional Schedule

Committee meeting 03 April 2025
Expected publication 25 June 2025

Project Team

Project lead Leena Issa

Email enquiries

External Assessment Group Warwick Evidence, Warwick Medical School, University of Warwick

Stakeholders

Companies sponsors Autolus (obecabtagene autoleucel)
Others Department of Health and Social Care
  NHS England
Patient carer groups Anthony Nolan
  Leukaemia UK
Professional groups Association of Cancer Physicians
  Cancer Research UK
  Royal College of Physicians
  Royal College of Radiologists
Associated public health groups None
Comparator companies AAH Pharmaceuticals (dasatinib, imatinib) (confidentiality agreement not signed, not participating)
  Accord UK (cytarabine, filgrastim, fludarabine, imatinib, pegfilgrastim) (confidentiality agreement not signed, not participating)
  Amarox (imatinib) (confidentiality agreement not signed, not participating)
  Amgen (blinatumomab, filgrastim, pegfilgrastim) (confidentiality agreement not signed, not participating)
  Aurobindo (Milpharm) (imatinib) (confidentiality agreement not signed, not participating)
  Chugai Pharma UK Ltd (lenograstim) (confidentiality agreement not signed, not participating)
  Cipla EU (imatinib) (confidentiality agreement not signed, not participating)
  Dr. Reddy’s Laboratories (imatinib) (confidentiality agreement not signed, not participating)
  Hospira UK (cytarabine) (confidentiality agreement not signed, not participating)
  Incyte Biosciences UK (ponatinib) (confidentiality agreement not signed, not participating)
  Mylan (dasatinib) (confidentiality agreement not signed, not participating)
  Napp Pharmaceuticals (pegfilgrastim) (confidentiality agreement not signed, not participating)
  Novartis (imatinib, tisagenlecleucel) (confidentiality agreement signed, participating)
  Pfizer (cytarabine, filgrastim, idarubicin, inotuzumab ozogamicin) (confidentiality agreement not signed, not participating)
  Sandoz (dasatinib, filgrastim, imatinib, pegfilgrastim) (confidentiality agreement not signed, not participating)
  Sanofi (fludarabine) (confidentiality agreement not signed, not participating)
  Teva UK (dasatinib, fludarabine, lipegfilgrastim) (confidentiality agreement not signed, not participating)
  Viatris UK Healthcare (dasatinib)(confidentiality agreement not signed, not participating)
  Zentiva (dasatinib) (confidentiality agreement not signed, not participating)
General commentators All Wales Therapeutics and Toxicology Centre
  British National Formulary
  Department of Health – Northern Ireland
  Healthcare Improvement Scotland
  Medicines and Healthcare products Regulatory Agency
  Scottish Medicines Consortium
  Welsh Government
  Welsh Health Specialised Services Committee
Relevant research groups Institute of Cancer Research

Timeline

Key events during the development of the guidance:

Date Update
05 September 2024 Invitation to participate
11 July 2024 - 08 August 2024 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators: 6347
11 July 2024 In progress. Scoping commenced.
22 January 2024 Awaiting development. Status change linked to Topic Selection Decision being set to Selected

For further information on our processes and methods, please see our CHTE processes and methods manual