Suggested remit: To appraise the clinical and cost effectiveness of dostarlimab with platinum-based chemotherapy within its marketing authorisation for treating primary advanced or recurrent endometrial cancer with microsatellite stable (MSS) or mismatch repair proficient (pMMR) tumours in adults.
 
Status In progress
Technology type Medicine
Decision Selected
Reason for decision Anticipate the topic will be of importance to patients, carers, professionals, commissioners and the health of the public to ensure clinical benefit is realised, inequalities in use addressed, and help them make the best use of NHS resources
Process STA Standard
ID number 6415

Provisional Schedule

Committee meeting 01 July 2025
Expected publication 10 September 2025

Project Team

Project lead Greg O'Toole

Email enquiries

External Assessment Group BMJ Technology Assessment Group (BMJ-TAG), BMJ

Stakeholders

Companies sponsors GlaxoSmithKline (dostarlimab)
Others Department of Health and Social Care
  NHS England
Patient carer groups None
Professional groups Association of Cancer Physicians
  Cancer Research UK
  Royal College of Physicians
  Royal College of Radiologists
Associated public health groups None
Comparator companies AstraZeneca (durvalumab, olaparib) (confidentiality agreement signed, participating)
  Merck Sharp & Dohme (pembrolizumab) (confidentiality agreement signed, participating)
  Accord (carboplatin, paclitaxel, cisplatin, doxorubicin) (confidentiality agreement not signed, not participating)
  Alliance Healthcare (cyclophosphamide, paclitaxel) (confidentiality agreement not signed, not participating)
  Bausch & Lomb (megestrol acetate) (confidentiality agreement not signed, not participating)
  Baxter Healthcare (cyclophosphamide) (confidentiality agreement not signed, not participating)
  Bristol Myers Squibb Pharmaceuticals (paclitaxel) (confidentiality agreement not signed, not participating)
  Consilient Health (carboplatin) (confidentiality agreement not signed, not participating)
  Fresenius Kabi (carboplatin, paclitaxel) (confidentiality agreement not signed, not participating)
  Hospira UK (carboplatin, paclitaxel) (confidentiality agreement not signed, not participating)
  Johnson & Johnson Innovative Medicine (doxorubicin) (confidentiality agreement not signed, not participating)
  Medac GmbH (doxorubicin) (confidentiality agreement not signed, not participating)
  Novartis (cisplatin, cyclophosphamide) (confidentiality agreement not signed, not participating)
  Pfizer (carboplatin, paclitaxel, cisplatin, doxorubicin, medroxyprogesterone acetate) (confidentiality agreement not signed, not participating)
  Sandoz (cyclophosphamide) (confidentiality agreement not signed, not participating)
  Seacross Pharmaceuticals (paclitaxel, doxorubicin) (confidentiality agreement not signed, not participating)
  Teva UK (carboplatin, paclitaxel) (confidentiality agreement not signed, not participating)
General commentators All Wales Therapeutics and Toxicology Centre
  British National Formulary
  Department of Health - Northern Ireland
  Healthcare Improvement Scotland
  Medicines and Healthcare products Regulatory Agency
  Scottish Medicines Consortium
  Welsh Government
Relevant research groups Institute of Cancer Research

Timeline

Key events during the development of the guidance:

Date Update
18 November 2024 Invitation to participate
05 September 2024 - 03 October 2024 Consultation on suggested remit, draft scope and provisional stakeholder list of consultees and commentators: 6415
05 September 2024 In progress. Scoping commencing
30 January 2024 Awaiting development. Status change linked to Topic Selection Decision being set to Selected
30 January 2024 Topic selection

For further information on our processes and methods, please see our CHTE processes and methods manual