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Guidance, NICE advice and quality standards in development
Title
Type
Expected publication date
Eplontersen for treating hereditary transthyretin-related amyloidosis [ID6337]
Technology appraisal guidance
27 November 2024
ERC1671 for treating progressed or recurrent grade IV glioma (glioblastoma or gliosarcoma) [ID1623]
Technology appraisal guidance
TBC
Erdafitinib for treating metastatic or unresectable FGFR-altered urothelial cancer [ID1333]
Technology appraisal guidance
26 February 2025
Evobrutinib for treating relapsing multiple sclerosis [ID6313]
Technology appraisal guidance
TBC
Evolocumab for preventing major cardiovascular events in people aged 50 to 79 at high risk who have not had a myocardial infarction or stroke TS ID 11920
Technology appraisal guidance
TBC
Exagamglogene autotemcel for treating sickle cell disease [ID4016]
Technology appraisal guidance
TBC
Fenfluramine for treating seizures associated with Lennox–Gastaut syndrome in people 2 years and over [ID1651]
Technology appraisal guidance
TBC
Fezolinetant for treating vasomotor symptoms associated with the menopause [ID5071]
Technology appraisal guidance
21 May 2025
Fidanacogene elaparvovec for treating moderately severe to severe haemophilia B [ID4032]
Technology appraisal guidance
TBC
Fordadistrogene movaparvovec for treating Duchenne muscular dystrophy [ID6133]
Technology appraisal guidance
TBC
Fruquintinib for previously treated metastatic colorectal cancer ID6274
Technology appraisal guidance
5 March 2025
Ganaxolone for treating seizures caused by CDKL5 deficiency disorder in people 2 years and over [ID3988]
Technology appraisal guidance
TBC
Garadacimab for preventing recurrent attacks of hereditary angioedema in people 12 years and over [ID6394]
Technology appraisal guidance
25 June 2025
Givinostat for treating Duchenne muscular dystrophy in people 6 years and over [ID6323]
Technology appraisal guidance
TBC
Glaucoma - lerdelimumab (CAT-152) [ID383]
Technology appraisal guidance
TBC
Glofitamab with gemcitabine and oxaliplatin for treating relapsed or refractory diffuse B-cell lymphoma [ID6202]
Technology appraisal guidance
TBC
Guselkumab for previously treated moderately to severely active Crohn's disease ID6238
Technology appraisal guidance
TBC
Guselkumab for treating moderately to severely active ulcerative colitis ID6237
Technology appraisal guidance
TBC
Histamine dihydrochloride with interleukin-2 for maintenance treatment of acute myeloid leukaemia [ID1627]
Technology appraisal guidance
TBC
Hydromethylthionine mesylate for treating mild cognitive impairment or mild or moderate dementia caused by Alzheimer's disease [ID6343]
Technology appraisal guidance
30 April 2025
Ibrutinib for treating relapsed or refractory follicular lymphoma [1251]
Technology appraisal guidance
TBC
Idebenone for treating visual impairment in Leber's hereditary optic neuropathy in people 12 years and over [ID547]
Technology appraisal guidance
23 April 2025
Imetelstat for treating relapsed or refractory transfusion-dependent myelodysplastic syndromes [ID3922]
Technology appraisal guidance
TBC
Imlunestrant for treating oestrogen receptor-positive HER2-negative advanced breast cancer after endocrine therapy [ID6373]
Technology appraisal guidance
TBC
Infigratinib for treating relapsed or refractory advanced cholangiocarcinoma with FGFR2 fusion or rearrangement [ID3992]
Technology appraisal guidance
TBC
Inhaled treprostinil for treating pulmonary hypertension caused by interstitial lung disease ID6459
Technology appraisal guidance
TBC
Insulin icodec for treating type 2 diabetes [ID6175]
Technology appraisal guidance
TBC
Iodine (131I)–apamistamab for treating relapsed or refractory acute myeloid leukaemia before an allogeneic haematopoietic stem cell transplant [ID6355]
Technology appraisal guidance
TBC
Ipatasertib with abiraterone and prednisone for hormone-relapsed metastatic prostate cancer [ID3889]
Technology appraisal guidance
TBC
Iptacopan for treating complement 3 glomerulopathy ID6283
Technology appraisal guidance
TBC
Isatuximab in combination for untreated multiple myeloma when a stem cell transplant is unsuitable ID3981
Technology appraisal guidance
16 July 2025
Isatuximab with pomalidomide and dexamethasone for treating relapsed and refractory multiple myeloma [Review of TA658] [ID4067]
Technology appraisal guidance
TBC
Ixazomib citrate for maintenance treatment of untreated multiple myeloma in people who cannot have autologous stem cell transplant [ID2706]
Technology appraisal guidance
TBC
KTE-X19 for previously treated B-precursor acute lymphoblastic leukaemia in people aged 2 to 21 [ID1336]
Technology appraisal guidance
TBC
Lacosamide for adjunctive treatment of primary generalised tonic-clonic seizures in epilepsy [ID1687]
Technology appraisal guidance
TBC
Lecanemab for treating mild cognitive impairment or mild dementia caused by Alzheimer's disease [ID4043]
Technology appraisal guidance
5 February 2025
Lenadogene nolparvovec for treating Leber's hereditary optic neuropathy caused by the G11778A ND4 mitochondrial mutation [ID1410]
Technology appraisal guidance
TBC
Lenvatinib with pembrolizumab for untreated recurrent or advanced endometrial cancer [ID3966]
Technology appraisal guidance
TBC
Leriglitazone for treating andrenoleukodystrophy [ID3903]
Technology appraisal guidance
TBC
Letermovir for preventing cytomegalovirus infection after a kidney transplant [ID6166]
Technology appraisal guidance
TBC
Leukocyte interleukin in combination for neoadjuvant treatment of resectable locally advanced squamous cell head and neck cancer [ID6390]
Technology appraisal guidance
TBC
Lifileucel for previously treated unresectable or metastatic melanoma ID3863
Technology appraisal guidance
TBC
Linzagolix for treating symptoms of endometriosis [ID6357]
Technology appraisal guidance
25 June 2025
Lisocabtagene maraleucel for treating relapsed or refractory chronic lymphocytic leukaemia or small lymphocytic lymphoma [ID6174]
Technology appraisal guidance
TBC
Lisocabtagene maraleucel for treating relapsed or refractory large B-cell lymphomas after first-line chemotherapy when a stem cell transplant is suitable [ID3887]
Technology appraisal guidance
TBC
LN-145 for treating recurrent, persistent or metastatic cervical cancer [ID3844]
Technology appraisal guidance
TBC
Lorlatinib for untreated ALK-positive advanced non-small-cell lung cancer (Review of TA909) [ID6434]
Technology appraisal guidance
30 April 2025
Lung cancer (non-small-cell, advanced or metastatic maintenance treatment) - erlotinib (in combination with bevacizumab) [ID44]
Technology appraisal guidance
TBC
Lung cancer (non-small-cell, advanced or metastatic second line) - erlotinib (in combination with bevacizumab) [ID43]
Technology appraisal guidance
TBC
Lurbinectedin for treating advanced platinum-resistant ovarian cancer ID1340
Technology appraisal guidance
TBC
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