Research recommendation(s) from an individual piece of guidance Guidance: Epiretinal brachytherapy for wet age-related macular degeneration Date issued: 16 December 2011 Research recommendations coming out of this guidance Epiretinal brachytherapy for wet age-related macular degeneration (AMD) should only be used in the context of research. Research studies should address whether epiretinal brachytherapy reduces the progression of wet AMD and whether it can reduce the number of injections of antivascular endothelial growth factor agents (anti-VEGF) required. Long-term outcomes should be reported.