Research recommendation(s) from an individual piece of guidance Guidance: Percutaneous balloon cryoablation for pulmonary vein isolation in atrial fibrillation Date issued: 27 May 2012 Research recommendations coming out of this guidance NICE encourages clinicians to enter patients into research studies with the particular aims of guiding selection of patients and of defining the place of percutaneous balloon cryoablation in relation to other procedures for treating atrial fibrillation. Further research should define patient selection criteria clearly and should document adverse events and long-term control of atrial fibrillation.