Research recommendation(s) from an individual piece of guidance Guidance: Insertion of a collagen plug to close an abdominal wall enterocutaneous fistula Date issued: 27 November 2014 Research recommendations coming out of this guidance NICE encourages further research into insertion of a collagen plug to close an abdominal wall enterocutaneous fistula. Research should ideally take the formof prospective studies that compare the course of the enterocutaneous fistula (its natural history) with and without use of the procedure. Reports should record the conditions underlying all fistulas that are treated, their location, whether they are high or low output, and details of previous treatments. NICE may update the guidance on publication of further evidence.