Research recommendation(s) from an individual piece of guidance Guidance: Unilateral MRI-guided focused ultrasound thalamotomy for treatment-resistant essential tremor Date issued: 20 June 2018 Research recommendations coming out of this guidance Further research on the safety of unilateral MRI-guided focused ultrasound thalamotomy for treatment-resistant essential tremor, which could include randomised controlled trials, should address patient selection, report on functional improvement and quality of life, and provide long-term follow-up data.