Research recommendation(s) from an individual piece of guidance Guidance: Permanent His-bundle pacemaker implantation for treating heart failure Date issued: 05 May 2021 Research recommendations coming out of this guidance Evidence on the safety and efficacy of permanent His-bundle pacemaker implantation for treating heart failure is inadequate in quality and quantity.Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.