Data were identified by the sponsor on the rates of healing for non-union long bone fractures treated by surgery. Healing rates ranged from 62% to 100%, and healing time ranged from 9 weeks (Livani et al. 2010) to 24 weeks (Ring et al. 1997). Across 3 case series and 1 cohort study, including a total of 166 patients with non-union fractures treated by surgery, 10 patients needed further surgery (follow-up not reported; Birjandinejad et al. 2009, Khalil et al. 2010, Lin et al. 2010 and Ring et al. 1997). These studies reported on fractures of different long bones, including distal femur, femur, tibia and ulna/radius.