Guidance

Recommendations for research

Recommendations for research

The guideline committee has made the following recommendations for research.

Key recommendations for research

1 Fibromyalgia or persistent treatment-resistant neuropathic pain in adults

For adults with fibromyalgia or persistent treatment-resistant neuropathic pain, what is the clinical and cost effectiveness of cannabidiol (CBD), containing no, or traces of, delta-9-tetrahydrocannabinol (THC), as an add-on to standard treatment?

For a short explanation of why the committee made the recommendation for research, see the rationale section on chronic pain.

Full details of the evidence and the committee's discussion are in evidence review B: chronic pain.

2 Chronic pain in children and young people

For children and young people with intractable cancer-related pain and pain associated with specific diseases (such as epidermolysis bullosa), what is the clinical and cost effectiveness of cannabis-based medicinal products as an add-on to standard treatment to improve symptoms compared with treatment with standard care?

For a short explanation of why the committee made the recommendation for research, see the rationale section on chronic pain.

Full details of the evidence and the committee's discussion are in evidence review B: chronic pain.

3 CBD for severe treatment-resistant epilepsy

What is the clinical and cost effectiveness of CBD in epileptic disorders in children, young people and adults?

For a short explanation of why the committee made the recommendation for research, see the rationale section on severe treatment-resistant epilepsy.

Full details of the evidence and the committee's discussion are in evidence review D: epilepsy.

4 THC in combination with CBD for severe treatment-resistant epilepsy

Does the addition of THC to CBD have an effect on seizure frequency, brain structure and neuropsychological performance when compared with both CBD alone and placebo in epileptic disorders in children, young people and adults?

For a short explanation of why the committee made the recommendation for research, see the rationale section on severe treatment-resistant epilepsy.

Full details of the evidence and the committee's discussion are in evidence review D: epilepsy.

5 Spasticity

What is the clinical and cost effectiveness of cannabis-based medicinal products other than THC: CBD spray for children, young people and adults with spasticity? In particular, what is the impact of spasticity on improvements in quality of life?

For a short explanation of why the committee made the recommendation for research, see the rationale section on spasticity.

Full details of the evidence and the committee's discussion are in evidence review C: spasticity.

Other recommendations for research

6 Chemotherapy-induced intractable nausea and vomiting in adults

What is the clinical and cost effectiveness of cannabis-based medicinal products as an add-on treatment for adults with chemotherapy-induced nausea and vomiting which persists with optimised conventional antiemetics?

7 Chemotherapy-induced intractable nausea and vomiting in babies, children and young people

What is the clinical and cost effectiveness of cannabis-based medicinal products as an add-on treatment in babies, children and young people with chemotherapy-induced nausea or vomiting which persists with optimised conventional antiemetics?

8 Intractable nausea and vomiting not caused by chemotherapy in adults

What is the clinical and cost effectiveness of cannabis-based medicinal products as an add-on treatment for adults with persistent nausea or vomiting not caused by chemotherapy which hasn't fully responded to optimised conventional antiemetics?

9 Intractable nausea and vomiting not caused by chemotherapy in babies, children and young people

What is the clinical and cost effectiveness of cannabis-based medicinal products as an add-on treatment for babies, children and young people with persistent nausea or vomiting not caused by chemotherapy which hasn't fully responded to optimised conventional antiemetics?