Neonatal infection: antibiotics for prevention and treatment

Risk factors for and clinical indicators of early-onset infection: What is the accuracy of clinical prediction models for early-onset neonatal infection in the UK and what is their effectiveness in guiding management in the baby?

Intrapartum antibiotics: What is the clinical and cost effectiveness of intrapartum antibiotics for women with meconium-stained amniotic fluid?

Antibiotics for suspected early-onset infection: What is the incidence in England and Wales of resistance to commonly used antibiotics among bacteria that cause early-onset neonatal infection?

Antibiotics for suspected early-onset infection: What is the optimal antibiotic dosage regimen for the treatment of early-onset neonatal infection?

Antibiotics for suspected early-onset infection: What is the incidence and severity of adverse effects with antibiotics used to prevent or treat early-onset neonatal infection?

Antibiotics for suspected early-onset infection: What are the core exposures and outcomes that should be used to evaluate clinical effectiveness of antibiotics to prevent or treat early- onset neonatal infection?

Intravascular catheters for reducing the risk of late-onset neonatal infection: What is the effectiveness of antimicrobial-impregnated catheters other than those impregnated with rifampicin and miconazole for preventing late-onset catheter-related bloodstream infections in newborn babies?

Intravascular catheters for reducing the risk of late-onset neonatal infection: What is the effectiveness of catheters impregnated with silver zeolite for preventing late-onset catheter-related bloodstream infections in newborn babies?

Antifungals to prevent fungal infection during antibiotic treatment for late-onset neonatal infection: What is the optimum regimen (including treatment duration and dose) for using antifungals to prevent secondary fungal infection associated with antibiotic treatment for late-onset neonatal infection?

Early and late-onset meningitis: What is the optimal antibiotic treatment regimen for early-onset neonatal meningitis?

Care setting: What is the clinical and cost effectiveness of different models of care for the prevention and treatment of early-onset neonatal infection?

Risk factors for and clinical indicators of early-onset infection: What is the risk of early-onset neonatal infection with maternal obesity and how does this change with increasing body mass index?

Investigations for babies who may have early-onset infection: What is the clinical and cost effectiveness of laboratory investigations used individually or in combination to exclude early-onset neonatal infection in babies receiving antibiotics for suspected infection?

Antibiotics for suspected early-onset neonatal infection: What is the optimal duration of treatment (course length) in babies who receive antibiotics for confirmed early-onset neonatal infection?

Risk factors for and clinical indicators of late-onset infection: What is the accuracy of new or existing clinical prediction models for late-onset neonatal infection in the UK and what is their effectiveness in guiding management:

- for babies already on a neonatal unit?

- for babies admitted from home? 

Antibiotics for suspected late-onset neonatal infection: What is the optimal antibiotic treatment regimen for suspected late-onset neonatal infection?

Impact of neonatal infection on the baby's family: What is the impact of neonatal infection on the health-related quality of life of the baby's family?

Information and support: How does each step in the care pathway for prevention and treatment of early-onset neonatal infection impact on babies and their families?

Information and support: What is the clinical and cost effectiveness of information and support offered to parents and carers of babies who have received antibiotics for suspected or proven early-onset neonatal infection?