Subarachnoid haemorrhage caused by a ruptured aneurysm: diagnosis and management

Timing of CT head scans: What is the relative accuracy of CT head scans at different time intervals, for example 12 hours or 24 hours after symptom onset, to diagnose subarachnoid haemorrhage?

Predictors of death and disability: What variables predict death or disability for people with aneurysmal subarachnoid haemorrhage?

Nimodipine: What is the clinical and cost effectiveness of nimodipine in the management of aneurysmal subarachnoid haemorrhage?

Novel endovascular interventions: What is the clinical and cost effectiveness of novel endovascular techniques and devices such as coated coils, endoluminal flow diverters and intrasaccular devices to treat aneurysmal subarachnoid haemorrhage?

Risk stratification tool to estimate risk of recurrence: What is the utility of a risk stratification tool to estimate the risk of subsequent aneurysmal subarachnoid haemorrhage?

Interventions for aneurysmal subarachnoid haemorrhage in people with major neurological deficit: What is the outcome of intervention to prevent rebleeding in people who present with or rapidly develop severe neurological deficits as a consequence of acute aneurysmal subarachnoid haemorrhage?

Managing acute hydrocephalus: What is the most clinically and cost-effective method of cerebrospinal fluid drainage or diversion (for example shunt surgery, external ventricular drain surgery or lumbar drain) for symptomatic acute hydrocephalus?

Transcranial doppler monitoring: What is the clinical and cost effectiveness of routine transcranial doppler monitoring to guide clinical management of aneurysmal subarachnoid haemorrhage?

Intracranial hypertension: What is the impact of routine monitoring of intracranial hypertension on subsequent management and outcome in people with aneurysmal subarachnoid haemorrhage who are unconscious or ventilated on an intensive care unit?

Intra-arterial therapies to manage delayed cerebral ischaemia: What is the impact of intra-arterial therapies to manage delayed cerebral ischaemia on outcome in people with aneurysmal subarachnoid haemorrhage?

Vasopressors to manage delayed cerebral ischaemia: What is the clinical and cost effectiveness of vasopressors to manage delayed cerebral ischaemia in people with aneurysmal subarachnoid haemorrhage?

Blood pressure targets: What is the clinical and cost effectiveness of a lower blood pressure treatment target relative to the standard blood pressure treatment target for people with aneurysmal subarachnoid haemorrhage?

Investigations for relatives: What is the clinical and cost effectiveness of investigations to detect intracranial arterial aneurysms in first-degree relatives of people who have had an aneurysmal subarachnoid haemorrhage?