Research recommendations coming out of this guidance In people with suspected TB, what is the relative clinical and cost effectiveness of universal andrisk-based use of rapid nucleic acid amplification tests? Apart from culture, what other diagnostic tests or combinations of tests are effective inestablishing an accurate diagnosis of active respiratory TB in children and young people withsuspected active TB? For isoniazid-resistant TB, what is the most effective regimen for reducing mortality andmorbidity? What effects does isolation have on the quality of life of people being treated for TB? For people with active, drug susceptible TB who experience treatment interruptions because of adverse events, particularly hepatotoxicity, what approach to re-establishing treatment is mosteffective in reducing mortality and morbidity?
In people with suspected TB, what is the relative clinical and cost effectiveness of universal andrisk-based use of rapid nucleic acid amplification tests?
Apart from culture, what other diagnostic tests or combinations of tests are effective inestablishing an accurate diagnosis of active respiratory TB in children and young people withsuspected active TB?
For people with active, drug susceptible TB who experience treatment interruptions because of adverse events, particularly hepatotoxicity, what approach to re-establishing treatment is mosteffective in reducing mortality and morbidity?