Suspected sepsis: recognition, diagnosis and early management

Epidemiological study on presentation and management of sepsis in England:- What is the incidence, presentation and management of sepsis in the United Kingdom?

A complex service evaluation of implementation of NICE Sepsis guideline:- What effect will the NICE sepsis guideline have on patient care processes and outcomes in the UK over the next 5 years?

Use of biomarkers to diagnose and initiate treatment:- What is the clinical and cost effectiveness of procalcitonin (PCT) point-of-care tests at initial triage for diagnosis of serious infection and the initiation of appropriate antibiotic therapy?

Validation of clinical early warning scores in pre-hospital and emergency care settings:- Can early warning scores, for example NEWS (national early warning scores for adults) and PEWS (paediatric early warning score), be used to improve the detection of sepsis and facilitate prompt and appropriate clinical response in pre-hospital settings and in emergency departments?

Derivation of clinical decision rules in suspected sepsis:- Is it possible to derive and validate a set of clinical decision rules or a predictive tool to rule outsepsis which can be applied to patients presenting to hospital; with suspected sepsis?

In adults and young people (16 and over) with suspected sepsis in acute hospital settings, ambulance trusts and acute mental health facilities, what is the association between NEWS2 bands (0, 1 to 4, 5 to 6, 7 or above) and risk of severe illness or death? In adults and young people (16 and over) with suspected sepsis in acute hospital settings, ambulance trusts and acute mental health facilities, what is the association between the NEWS2 score of 3 in a single parameter and risk of severe illness or death?