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Showing 1 to 1535 of 1535

Published guidance, NICE advice and quality standards
TitleReference numberPublishedLast updated
Endoscopic bipolar radiofrequency ablation for malignant biliary obstructionIPG794
Elafibranor for previously treated primary biliary cholangitisTA1016
Alectinib for adjuvant treatment of ALK-positive non-small-cell lung cancerTA1014
Teclistamab for treating relapsed and refractory multiple myeloma after 3 or more treatmentsTA1015
Endometriosis: diagnosis and managementNG73
Menopause: identification and managementNG23
Avapritinib for treating advanced systemic mastocytosisTA1012
Heart failure algorithms for remote monitoring in people with cardiac implantable electronic devicesDG61
Danicopan with ravulizumab or eculizumab for treating paroxysmal nocturnal haemoglobinuriaTA1010
Quizartinib for induction, consolidation and maintenance treatment of newly diagnosed FLT3-ITD-positive acute myeloid leukaemiaTA1013
Digital technologies for assessing attention deficit hyperactivity disorder (ADHD)DG60
Belzutifan for treating tumours associated with von Hippel-Lindau diseaseTA1011
Acute kidney injury: prevention, detection and managementNG148
Latanoprost–netarsudil for previously treated primary open-angle glaucoma or ocular hypertensionTA1009
Trifluridine–tipiracil with bevacizumab for treating metastatic colorectal cancer after 2 systemic treatmentsTA1008
Burosumab for treating X-linked hypophosphataemia in children and young peopleHST8
Rucaparib for maintenance treatment of relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancerTA1007
Empagliflozin for treating type 2 diabetes in people 10 to 17 years (terminated appraisal)TA1006
Evinacumab for treating homozygous familial hypercholesterolaemia in people 12 years and overTA1002
Exagamglogene autotemcel for treating transfusion-dependent beta-thalassaemia in people 12 years and overTA1003
Faricimab for treating visual impairment caused by macular oedema after retinal vein occlusionTA1004
Futibatinib for previously treated advanced cholangiocarcinoma with FGFR2 fusion or rearrangementTA1005
Iptacopan for treating paroxysmal nocturnal haemoglobinuriaTA1000
Zanubrutinib for treating marginal zone lymphoma after anti-CD20-based treatmentTA1001
Vibegron for treating symptoms of overactive bladder syndromeTA999
Single-step scaffold insertion for repairing symptomatic chondral knee defectsIPG793
Pembrolizumab with platinum- and fluoropyrimidine-based chemotherapy for untreated advanced HER2-negative gastric or gastro-oesophageal junction adenocarcinomaTA997
Pembrolizumab with platinum- and fluoropyrimidine-based chemotherapy for untreated advanced oesophageal and gastro-oesophageal junction cancerTA737
Adrenal insufficiency: identification and managementNG243
Risankizumab for treating moderately to severely active ulcerative colitisTA998
Phrenic nerve pacing for congenital central hypoventilation syndromeIPG790
Caval valve implantation for tricuspid regurgitationIPG791
Phrenic nerve pacing for ventilator-dependent high cervical spinal cord injuryIPG792
Relugolix for treating hormone-sensitive prostate cancerTA995
Linzagolix for treating moderate to severe symptoms of uterine fibroidsTA996
Diabetic retinopathy: management and monitoringNG242
Enzalutamide for treating non-metastatic prostate cancer after radical prostatectomy or radiotherapy (terminated appraisal)TA994
Abaloparatide for treating osteoporosis after menopauseTA991
Burosumab for treating X-linked hypophosphataemia in adultsTA993
CYP2C19 genotype testing to guide clopidogrel use after ischaemic stroke or transient ischaemic attackDG59
AnaphylaxisQS119
Trastuzumab deruxtecan for treating HER2-low metastatic or unresectable breast cancer after chemotherapyTA992
Ivacaftor–tezacaftor–elexacaftor, tezacaftor–ivacaftor and lumacaftor–ivacaftor for treating cystic fibrosisTA988
Etranacogene dezaparvovec for treating moderately severe or severe haemophilia BTA989
Tenecteplase for treating acute ischaemic strokeTA990
Lebrikizumab for treating moderate to severe atopic dermatitis in people 12 years and overTA986
Lisocabtagene maraleucel for treating relapsed or refractory aggressive B-cell non-Hodgkin lymphoma (terminated appraisal)TA987
Selective internal radiation therapy with QuiremSpheres for treating unresectable advanced hepatocellular carcinomaTA985
Selective internal radiation therapies for treating hepatocellular carcinomaTA688
Minimally invasive percutaneous surgical techniques with internal fixation for correcting hallux valgusIPG789
Tafamidis for treating transthyretin amyloidosis with cardiomyopathyTA984
Baricitinib for treating juvenile idiopathic arthritis in people 2 years and over (terminated appraisal)TA982
Pembrolizumab with trastuzumab and chemotherapy for untreated locally advanced unresectable or metastatic HER2-positive gastric or gastro-oesophageal junction adenocarcinomaTA983
Ivosidenib with azacitidine for untreated acute myeloid leukaemia with an IDH1 R132 mutationTA979
Nivolumab for adjuvant treatment of completely resected melanoma at high risk of recurrence in people 12 years and over (terminated appraisal)TA980
Trastuzumab deruxtecan for treating HER2-mutated advanced non-small-cell lung cancer after platinum-based chemotherapy (terminated appraisal)TA976
Dabrafenib with trametinib for treating BRAF V600E mutation-positive glioma in children and young people aged 1 year and overTA977
Zanubrutinib with obinutuzumab for treating relapsed or refractory B-cell follicular lymphoma after 2 or more treatments (terminated appraisal)TA978
Sirolimus for treating facial angiofibroma caused by tuberous sclerosis complex in people 6 years and over (terminated appraisal)TA972
Setmelanotide for treating obesity and hyperphagia in Bardet-Biedl syndromeHST31
Natalizumab for the treatment of adults with highly active relapsing–remitting multiple sclerosisTA127
Alemtuzumab for treating highly active relapsing–remitting multiple sclerosisTA312
Cladribine for treating relapsing–remitting multiple sclerosisTA616
Ranibizumab for treating visual impairment caused by macular oedema secondary to retinal vein occlusionTA283
Ranibizumab and pegaptanib for the treatment of age-related macular degenerationTA155
Ranibizumab for treating choroidal neovascularisation associated with pathological myopiaTA298
Selective internal radiation therapy for neuroendocrine tumours that have metastasised to the liverIPG786
Endoscopic duodenal mucosal resurfacing for insulin resistance in type 2 diabetesIPG787
Image-guided percutaneous laser ablation for primary and secondary liver tumoursIPG788
Atogepant for preventing migraineTA973
Selinexor with bortezomib and dexamethasone for previously treated multiple myelomaTA974
Tisagenlecleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia in people 25 years and underTA975
Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancerDG58
Selinexor with dexamethasone for treating relapsed or refractory multiple myeloma after 4 or more treatmentsTA970
Remdesivir and tixagevimab plus cilgavimab for treating COVID-19TA971
COVID-19 rapid guideline: managing COVID-19NG191
Artificial intelligence (AI)-derived software to help clinical decision making in strokeDG57
Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma in people 3 years and overTA967
Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphomaTA540
Digital technologies to deliver pulmonary rehabilitation programmes for adults with COPD: early value assessmentHTE18
Gefapixant for treating refractory or unexplained chronic cough (terminated appraisal)TA969
Melphalan flufenamide with dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)TA968
Pembrolizumab with gemcitabine and cisplatin for untreated advanced biliary tract cancer (terminated appraisal)TA966
Lymphovenous anastomosis during axillary or inguinal node dissection for preventing secondary lymphoedemaIPG785
Cabozantinib with nivolumab for untreated advanced renal cell carcinomaTA964
Twin and triplet pregnancyNG137
Dostarlimab with platinum-based chemotherapy for treating advanced or recurrent endometrial cancer with high microsatellite instability or mismatch repair deficiencyTA963
Kurin Lock for blood culture collectionMTG77
GaitSmart rehabilitation exercise programme for gait and mobility issuesMTG78
Epidermal radiotherapy using rhenium-188 paste for non-melanoma skin cancerIPG784
Sebelipase alfa for treating lysosomal acid lipase deficiency that is not Wolman disease (terminated appraisal)TA961
Olaparib for maintenance treatment of BRCA mutation-positive advanced ovarian, fallopian tube or peritoneal cancer after response to first-line platinum-based chemotherapyTA962
Human alpha1-proteinase inhibitor for treating emphysema (terminated appraisal)TA965
Ritlecitinib for treating severe alopecia areata in people 12 years and overTA958
Daratumumab in combination for treating newly diagnosed systemic amyloid light-chain amyloidosisTA959
Satralizumab for preventing relapses in neuromyelitis optica spectrum disorders (terminated appraisal)TA960
Desflurane for maintenance of anaesthesiaES41
Digital health technologies to help manage symptoms of psychosis and prevent relapse in adults and young people: early value assessmentHTE17
Ovarian cancer: identifying and managing familial and genetic riskNG241
Momelotinib for treating myelofibrosis-related splenomegaly or symptomsTA957
Suspected sepsis: recognition, diagnosis and early managementNG51
Neonatal infection: antibiotics for prevention and treatmentNG195
Meningitis (bacterial) and meningococcal disease: recognition, diagnosis and managementNG240
ProKnow cloud-based system for radiotherapy data storage, communication and management: early value assessmentHTE5
Nirmatrelvir plus ritonavir, sotrovimab and tocilizumab for treating COVID-19TA878
Fluocinolone acetonide intravitreal implant for treating chronic diabetic macular oedemaTA953
Dupilumab for treating moderate to severe prurigo nodularisTA955
Etrasimod for treating moderately to severely active ulcerative colitis in people aged 16 and overTA956
Lung cancer: diagnosis and managementNG122
Vitamin B12 deficiency in over 16s: diagnosis and managementNG239
Epcoritamab for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic treatmentsTA954
Digital technologies for delivering multidisciplinary weight-management services: early value assessmentHTE14
Digital technologies for managing non-specific low back pain: early value assessmentHTE16
Endoscopic sleeve gastroplasty for obesityIPG783
Talazoparib for treating HER2-negative advanced breast cancer with germline BRCA mutationsTA952
TuberculosisNG33
Digitally enabled therapies for adults with depression: early value assessmentHTE8
Belumosudil for treating chronic graft-versus-host disease after 2 or more systemic treatments in people 12 years and overTA949
Nivolumab–relatlimab for untreated unresectable or metastatic melanoma in people 12 years and overTA950
Olaparib with abiraterone for untreated hormone-relapsed metastatic prostate cancerTA951
Loncastuximab tesirine for treating relapsed or refractory diffuse large B-cell lymphoma and high-grade B-cell lymphoma after 2 or more systemic treatmentsTA947
Ivosidenib for treating advanced cholangiocarcinoma with an IDH1 R132 mutation after 1 or more systemic treatmentsTA948
Treosulfan with fludarabine before allogeneic stem cell transplant for people aged 1 month to 17 years with non-malignant diseases (terminated appraisal)TA945
Caesarean birthNG192
Devices for remote monitoring of Parkinson's diseaseDG51
COVID-19 rapid guideline: managing the long-term effects of COVID-19NG188
Skin cancerQS130
Pharyngeal electrical stimulation for neurogenic dysphagiaIPG781
Temperature control to improve neurological outcomes after cardiac arrestIPG782
Neonatal infectionQS75
Olaparib with bevacizumab for maintenance treatment of advanced high-grade epithelial ovarian, fallopian tube or primary peritoneal cancerTA946
Early and locally advanced breast cancer: diagnosis and managementNG101
Durvalumab with gemcitabine and cisplatin for treating unresectable or advanced biliary tract cancerTA944
Sebelipase alfa for treating Wolman diseaseHST30
Intravascular lithotripsy for calcified arteries in peripheral arterial diseaseIPG780
Bipolar disorder: assessment and managementCG185
Targeted-release budesonide for treating primary IgA nephropathyTA937
Ravulizumab for treating generalised myasthenia gravis (terminated appraisal)TA940
Ravulizumab for treating AQP4 antibody-positive neuromyelitis optica spectrum disorder (terminated appraisal)TA941
Empagliflozin for treating chronic kidney diseaseTA942
Epilepsies in children, young people and adultsQS211
Hybrid closed loop systems for managing blood glucose levels in type 1 diabetesTA943
Risdiplam for treating spinal muscular atrophyTA755
Digitally enabled therapies for adults with anxiety disorders: early value assessmentHTE9
Middle meningeal artery embolisation for chronic subdural haematomasIPG779
Cardiovascular disease: risk assessment and reduction, including lipid modificationNG238
Transition from children's to adults' servicesQS140
Pembrolizumab plus chemotherapy with or without bevacizumab for persistent, recurrent or metastatic cervical cancerTA939
Velmanase alfa for treating alpha-mannosidosisHST29
Dupilumab for treating eosinophilic oesophagitis in people 12 years and over (terminated appraisal)TA938
Acne vulgaris: managementNG198
Secukinumab for treating moderate to severe hidradenitis suppurativaTA935
Idecabtagene vicleucel for treating relapsed and refractory multiple myeloma after 3 or more treatments (terminated appraisal)TA936
Tisagenlecleucel for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic therapies (terminated appraisal)TA933
Foslevodopa–foscarbidopa for treating advanced Parkinson's with motor symptomsTA934
Percutaneous thrombectomy for intermediate-risk or high-risk pulmonary embolismIPG778
Decitabine–cedazuridine for untreated acute myeloid leukaemia when intensive chemotherapy is unsuitable (terminated appraisal)TA932
Zanubrutinib for treating chronic lymphocytic leukaemiaTA931
Percutaneous transarterial carotid artery stent placement for asymptomatic extracranial carotid stenosisIPG777
Transient loss of consciousness ('blackouts') in over 16sCG109
Hypertension in adults: diagnosis and managementNG136
Suspected acute respiratory infection in over 16s: assessment at first presentation and initial managementNG237
Lutetium-177 vipivotide tetraxetan for treating PSMA-positive hormone-relapsed metastatic prostate cancer after 2 or more treatmentsTA930
Virtual reality technologies for treating agoraphobia or agoraphobic avoidance: early value assessmentHTE15
Biodegradable subacromial spacer insertion for rotator cuff tearsIPG775
Extracorporeal carbon dioxide removal for acute respiratory failureIPG776
Familial breast cancer: classification, care and managing breast cancer and related risks in people with a family history of breast cancerCG164
Empagliflozin for treating chronic heart failure with preserved or mildly reduced ejection fractionTA929
Cabozantinib for previously treated advanced differentiated thyroid cancer unsuitable for or refractory to radioactive iodineTA928
Jaundice in newborn babies under 28 daysCG98
Pneumonia in adults: diagnosis and managementCG191
Acute respiratory infection in over 16s: initial assessment and management including virtual wards (hospital at home)QS210
Ranibizumab for treating diabetic macular oedemaTA274
Daratumumab with lenalidomide and dexamethasone for untreated multiple myeloma when a stem cell transplant is unsuitableTA917
Tirzepatide for treating type 2 diabetesTA924
Mirikizumab for treating moderately to severely active ulcerative colitisTA925
Baricitinib for treating severe alopecia areataTA926
Vaginal transluminal endoscopic hysterectomy and adnexal surgery for benign gynaecological conditionsIPG774
Tabelecleucel for treating post-transplant lymphoproliferative disorder caused by the Epstein-Barr virus (terminated appraisal)TA923
Rimegepant for treating migraineTA919
Tofacitinib for treating active ankylosing spondylitisTA920
Ruxolitinib for treating polycythaemia veraTA921
Daridorexant for treating long-term insomniaTA922
Percutaneous deep venous arterialisation for chronic limb-threatening ischaemiaIPG773
Stroke rehabilitation in adultsNG236
Glofitamab for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic treatmentsTA927
Virtual ward platform technologies for acute respiratory infectionsHTE13
Thyroid disease: assessment and managementNG145
Bimekizumab for treating axial spondyloarthritisTA918
Pegunigalsidase alfa for treating Fabry diseaseTA915
Bimekizumab for treating active psoriatic arthritisTA916
Urinary incontinence in neurological disease: assessment and managementCG148
Ovarian cancer: recognition and initial managementCG122
Suspected cancer: recognition and referralNG12
Suspected neurological conditions: recognition and referralNG127
Hearing loss in adults: assessment and managementNG98
Intrapartum careNG235
Artificial intelligence-derived software to analyse chest X-rays for suspected lung cancer in primary care referrals: early value assessmentHTE12
COVID-19 rapid guideline: haematopoietic stem cell transplantationNG164
Artificial intelligence technologies to aid contouring for radiotherapy treatment planning: early value assessmentHTE11
KardiaMobile 6L for measuring cardiac QT interval in adults having antipsychotic medicationHTE10
Removal, preservation and reimplantation of ovarian tissue for restoring fertility after gonadotoxic treatmentIPG772
Pembrolizumab for previously treated endometrial, biliary, colorectal, gastric or small intestine cancer with high microsatellite instability or mismatch repair deficiencyTA914
Birch bark extract for treating epidermolysis bullosaHST28
Chronic obstructive pulmonary disease in adultsQS10
Transurethral water-jet ablation for lower urinary tract symptoms caused by benign prostatic hyperplasiaIPG770
Cryotherapy for chronic rhinitisIPG771
Cirrhosis in over 16s: assessment and managementNG50
Mavacamten for treating symptomatic obstructive hypertrophic cardiomyopathyTA913
Spinal metastases and metastatic spinal cord compressionNG234
Spinal metastases and metastatic spinal cord compressionQS56
Guided self-help digital cognitive behavioural therapy for children and young people with mild to moderate symptoms of anxiety or low mood: early value assessmentHTE3
Semaglutide for managing overweight and obesityTA875
Otitis media with effusion in under 12sNG233
Quantitative faecal immunochemical testing to guide colorectal cancer pathway referral in primary careDG56
Ectopic pregnancy and miscarriage: diagnosis and initial managementNG126
Cipaglucosidase alfa with miglustat for treating late-onset Pompe diseaseTA912
Genedrive MT-RNR1 ID Kit for detecting a genetic variant to guide antibiotic use and prevent hearing loss in babies: early value assessmentHTE6
Aortic valve reconstruction with glutaraldehyde-treated autologous pericardium for aortic valve diseaseIPG769
Venous thromboembolic diseases: diagnosis, management and thrombophilia testingNG158
Selpercatinib for untreated RET fusion-positive advanced non-small-cell lung cancerTA911
Obesity: identification, assessment and managementCG189
Afamelanotide for treating erythropoietic protoporphyriaHST27
KardiaMobile for detecting atrial fibrillationMTG64
Semaglutide for managing overweight and obesity in young people aged 12 to 17 years (terminated appraisal)TA910
Lorlatinib for untreated ALK-positive advanced non-small-cell lung cancerTA909
Alcohol-use disorders: diagnosis and managementQS11
Rimegepant for preventing migraineTA906
Olaparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube or peritoneal cancer after 2 or more courses of platinum-based chemotherapyTA908
AI-derived computer-aided detection (CAD) software for detecting and measuring lung nodules in CT scan imagesDG55
Irreversible electroporation for treating prostate cancerIPG768
Oesophago-gastric cancer: assessment and management in adultsNG83
Depression in adultsQS8
Deucravacitinib for treating moderate to severe plaque psoriasisTA907
Botulinum toxin type A injections into the urethral sphincter for idiopathic chronic non-obstructive urinary retentionIPG766
Radiofrequency denervation for osteoarthritic knee painIPG767
Endoscopic ultrasound-guided gallbladder drainage for acute cholecystitis when surgery is not an optionIPG764
Minimally invasive fusionless posterior-approach surgery to correct idiopathic scoliosis in children and young peopleIPG765
Dapagliflozin for treating chronic heart failure with preserved or mildly reduced ejection fractionTA902
Darolutamide with androgen deprivation therapy and docetaxel for treating hormone-sensitive metastatic prostate cancerTA903
Pembrolizumab with lenvatinib for previously treated advanced or recurrent endometrial cancerTA904
Upadacitinib for previously treated moderately to severely active Crohn's diseaseTA905
Cemiplimab for treating recurrent or metastatic cervical cancer (terminated appraisal)TA901
MiraQ cardiac TTFM with high-frequency probe for assessing graft flow during coronary artery bypass graft surgeryMIB323
Dabrafenib plus trametinib for treating BRAF V600 mutation-positive advanced non-small-cell lung cancerTA898
Tixagevimab plus cilgavimab for preventing COVID-19TA900
YOURmeds for medication support in long-term conditionsMIB289
Axicabtagene ciloleucel for treating relapsed or refractory follicular lymphomaTA894
Axicabtagene ciloleucel for treating relapsed or refractory diffuse large B-cell lymphoma after first-line chemoimmunotherapyTA895
Bulevirtide for treating chronic hepatitis DTA896
Brexucabtagene autoleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia in people 26 years and overTA893
FibroScan for assessing liver fibrosis and cirrhosis outside secondary and specialist careDG48
Atopic eczema in under 12s: diagnosis and managementCG57
Daratumumab with bortezomib and dexamethasone for previously treated multiple myelomaTA897
Esketamine for treating major depressive disorder in adults at imminent risk of suicide (terminated appraisal)TA899
Intraoperative electron beam radiotherapy for locally advanced and locally recurrent colorectal cancerIPG763
Proov Confirm for ovulation confirmationMIB322
Transperineal biopsy for diagnosing prostate cancerDG54
Ibrutinib with venetoclax for untreated chronic lymphocytic leukaemiaTA891
Mosunetuzumab for treating relapsed or refractory follicular lymphomaTA892
Automated ankle brachial pressure index measurement devices to detect peripheral arterial disease in people with leg ulcersDG52
MRI fusion biopsy systems for diagnosing prostate cancerDG53
Intramuscular diaphragm stimulation for ventilator-dependent chronic respiratory failure from high spinal cord injuriesIPG762
Cardiovascular risk assessment and lipid modificationQS100
Head injuryQS74
Head injury: assessment and early managementNG232
Risankizumab for previously treated moderately to severely active Crohn's diseaseTA888
Ciltacabtagene autoleucel for treating relapsed or refractory multiple myeloma (terminated appraisal)TA889
Difelikefalin for treating pruritus in people having haemodialysisTA890
Diabetes (type 1 and type 2) in children and young people: diagnosis and managementNG18
Olaparib for adjuvant treatment of BRCA mutation-positive HER2-negative high-risk early breast cancer after chemotherapyTA886
Olaparib for previously treated BRCA mutation-positive hormone-relapsed metastatic prostate cancerTA887
Point-of-care tests for urinary tract infections to improve antimicrobial prescribing: early value assessmentHTE7
Ripretinib for treating advanced gastrointestinal stromal tumour after 3 or more treatmentsTA881
Voclosporin with mycophenolate mofetil for treating lupus nephritisTA882
Tafasitamab with lenalidomide for treating relapsed or refractory diffuse large B-cell lymphomaTA883
Capmatinib for treating advanced non-small-cell lung cancer with MET exon 14 skipping (terminated appraisal)TA884
Metastatic malignant disease of unknown primary origin in adults: diagnosis and managementCG104
Fasciotens for abdominal wall closureMIB321
Tezepelumab for treating severe asthmaTA880
Lumasiran for treating primary hyperoxaluria type 1HST25
Onasemnogene abeparvovec for treating spinal muscular atrophyHST15
Eladocagene exuparvovec for treating aromatic L-amino acid decarboxylase deficiencyHST26
Onasemnogene abeparvovec for treating presymptomatic spinal muscular atrophyHST24
Daytime intraoral neuromuscular electrical tongue stimulation using a removable device for obstructive sleep apnoeaIPG760
Endoscopic ultrasound-guided biliary drainage for biliary obstructionIPG761
Hypertension in pregnancy: diagnosis and managementNG133
AposHealth for knee osteoarthritisMTG76
Trastuzumab deruxtecan for treating HER2-positive unresectable or metastatic gastric or gastro-oesophageal junction cancer after anti-HER2 treatment (terminated appraisal)TA879
Radiofrequency ablation as an adjunct to balloon kyphoplasty or percutaneous vertebroplasty for palliation of painful spinal metastasesIPG759
Percutaneous thoracic duct embolisation for persistent chyle leakIPG755
Focal therapy using high-intensity focused ultrasound for localised prostate cancerIPG756
Maximal cytoreductive surgery for advanced ovarian cancerIPG757
Radiofrequency ablation for palliation of painful spinal metastasesIPG758
UrgoStart for treating diabetic foot ulcers and leg ulcersMTG42
Macimorelin for diagnosing growth hormone deficiencyMIB320
Acute kidney injuryQS76
Finerenone for treating chronic kidney disease in type 2 diabetesTA877
Nivolumab with chemotherapy for neoadjuvant treatment of resectable non-small-cell lung cancerTA876
CaRi-Heart for predicting cardiac risk in suspected coronary artery disease: early value assessmentHTE4
Type 1 diabetes in adultsQS208
Type 2 diabetes in adultsQS209
Eptinezumab for preventing migraineTA871
Cannabidiol for treating seizures caused by tuberous sclerosis complexTA873
Polatuzumab vedotin in combination for untreated diffuse large B-cell lymphomaTA874
Asfotase alfa for treating paediatric-onset hypophosphatasiaHST23
Endoluminal gastroplication for gastro-oesophageal reflux diseaseIPG753
Percutaneous transluminal renal sympathetic denervation for resistant hypertensionIPG754
Axicabtagene ciloleucel for treating diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma after 2 or more systemic therapiesTA872
Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myelomaTA870
Ataluren for treating Duchenne muscular dystrophy with a nonsense mutation in the dystrophin geneHST22
LIVERFASt for assessing and monitoring liver fibrosis, activity and steatosisMIB317
Mitapivat for treating pyruvate kinase deficiency (terminated appraisal)TA867
Vutrisiran for treating hereditary transthyretin-related amyloidosisTA868
Urinary tract infections in adultsQS90
Ambu aScope 4 RhinoLaryngo for visualising upper airways during rhinolaryngoscopyMIB316
Antenatal careQS22
Nivolumab with fluoropyrimidine- and platinum-based chemotherapy for untreated unresectable advanced, recurrent, or metastatic oesophageal squamous cell carcinomaTA865
Regorafenib for previously treated metastatic colorectal cancerTA866
Barrett's oesophagus and stage 1 oesophageal adenocarcinoma: monitoring and managementNG231
Transvenous obliteration for gastric varicesIPG751
Biodegradable spacer insertion to reduce rectal toxicity during radiotherapy for prostate cancerIPG752
Upadacitinib for treating active non-radiographic axial spondyloarthritisTA861
Trastuzumab deruxtecan for treating HER2-positive unresectable or metastatic breast cancer after 1 or more anti-HER2 treatmentsTA862
Somatrogon for treating growth disturbance in children and young people aged 3 years and overTA863
Nintedanib for treating idiopathic pulmonary fibrosis when forced vital capacity is above 80% predictedTA864
Aquablation robotic therapy for lower urinary tract symptoms caused by benign prostatic hyperplasiaMIB315
Maribavir for treating refractory cytomegalovirus infection after transplantTA860
Delirium: prevention, diagnosis and management in hospital and long-term careCG103
Trabeculectomy with a biodegradable collagen matrix implant for glaucomaIPG750
Ambu aScope 4 Broncho for routine diagnostic and therapeutic bronchoscopyMIB314
Angiotensin II for treating vasosuppressor-resistant hypotension caused by septic or distributive shock (terminated appraisal)TA859
Tobacco: preventing uptake, promoting quitting and treating dependenceNG209
Disabled children and young people up to 25 with severe complex needs: integrated service delivery and organisation across health, social care and educationNG213
MRI-based technologies for assessing non-alcoholic fatty liver diseaseDG50
Nivolumab with platinum- and fluoropyrimidine-based chemotherapy for untreated HER2-negative advanced gastric, gastro-oesophageal junction or oesophageal adenocarcinomaTA857
Lenvatinib with pembrolizumab for untreated advanced renal cell carcinomaTA858
Laparoscopic insertion of a magnetic ring for gastro-oesophageal reflux diseaseIPG749
Transcutaneous electrical stimulation of the trigeminal nerve for ADHDIPG748
PredictSURE IBD for inflammatory bowel disease prognosis: ulcerative colitisMIB313
Diabetes in pregnancyQS109
Chronic heart failure in adultsQS9
Hip fracture: managementCG124
Hip fracture in adultsQS16
Upadacitinib for treating moderately to severely active ulcerative colitisTA856
Percutaneous image-guided cryoablation of peripheral neuroma for chronic painIPG747
Thyroid cancer: assessment and managementNG230
Avatrombopag for treating primary chronic immune thrombocytopeniaTA853
Tobacco: treating dependenceQS207
Cabozantinib for previously treated advanced hepatocellular carcinomaTA849
Amivantamab for treating EGFR exon 20 insertion mutation-positive advanced non-small-cell lung cancer after platinum-based chemotherapyTA850
Pembrolizumab for neoadjuvant and adjuvant treatment of triple-negative early or locally advanced breast cancerTA851
Trifluridine–tipiracil for treating metastatic gastric cancer or gastro-oesophageal junction adenocarcinoma after 2 or more treatmentsTA852
Esketamine nasal spray for treatment-resistant depressionTA854
Fetal monitoring in labourNG229
PromarkerD for predicting the risk of diabetic kidney disease in people with type 2 diabetesMIB312
Memokath 051 Ureter stent for ureteric obstructionMTG75
Cemiplimab for untreated PD-L1-positive advanced or metastatic non-small-cell lung cancer (terminated appraisal)TA848
Mepolizumab for treating eosinophilic granulomatosis with polyangiitis (terminated appraisal)TA845
Mepolizumab for treating severe hypereosinophilic syndrome (terminated appraisal)TA846
Mepolizumab for treating severe chronic rhinosinusitis with nasal polyps (terminated appraisal)TA847
Optilume for treating recurrent bulbar urethral stricturesMTG73
GreenLight XPS for treating benign prostatic hyperplasiaMTG74
Luspatercept for treating anaemia caused by myelodysplastic syndromes (terminated appraisal)TA844
Luspatercept for treating anaemia caused by beta-thalassaemia (terminated appraisal)TA843
Tunnelled peritoneal drainage catheter insertion for refractory ascites in cirrhosisIPG746
Fractures (complex): assessment and managementNG37
Subarachnoid haemorrhage caused by a ruptured aneurysm: diagnosis and managementNG228
Carfilzomib with daratumumab and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)TA841
Tisagenlecleucel for treating follicular lymphoma after 2 or more therapies (terminated appraisal)TA842
Ab interno canaloplasty for open-angle glaucomaIPG745
Ruxolitinib for treating acute graft versus host disease refractory to corticosteroids (terminated appraisal)TA839
Ruxolitinib for treating chronic graft versus host disease refractory to corticosteroids (terminated appraisal)TA840
Percutaneous ultrasound-guided microwave ablation for symptomatic benign thyroid nodulesIPG743
Extracorporeal shockwave therapy for calcific tendinopathy in the shoulderIPG742
Advocacy services for adults with health and social care needsNG227
Slow-release potassium bicarbonate–potassium citrate for treating distal renal tubular acidosis (terminated appraisal)TA838
Digital technologies for the detection of melanomaMIB311
Pembrolizumab for adjuvant treatment of resected stage 2B or 2C melanomaTA837
Palbociclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapyTA836
Transcutaneous electrical stimulation of the supraorbital nerve for treating and preventing migraineIPG740
YAG laser vitreolysis for symptomatic vitreous floatersIPG741
Pembrolizumab for adjuvant treatment of renal cell carcinomaTA830
Relugolix–estradiol–norethisterone acetate for treating moderate to severe symptoms of uterine fibroidsTA832
Zanubrutinib for treating Waldenstrom's macroglobulinaemiaTA833
Fostamatinib for treating refractory chronic immune thrombocytopeniaTA835
Osteoarthritis in over 16s: diagnosis and managementNG226
Osteoarthritis in over 16sQS87
SQ HDM SLIT for treating allergic rhinitis and allergic asthma caused by house dust mites (terminated appraisal)TA834
O2matic PRO 100 for optimising oxygen treatment in respiratory conditionsMIB308
Oral azacitidine for maintenance treatment of acute myeloid leukaemia after induction therapyTA827
Ozanimod for treating moderately to severely active ulcerative colitisTA828
Magtrace and Sentimag system for locating sentinel lymph nodes for breast cancerMTG72
Signatera for detecting molecular residual disease from solid tumour cancersMIB307
Upadacitinib for treating active ankylosing spondylitisTA829
Atezolizumab for adjuvant treatment of resected non-small-cell lung cancerTA823
Postnatal careQS37
Neurostimulation of lumbar muscles for refractory non-specific chronic low back painIPG739
Avacopan for treating severe active granulomatosis with polyangiitis or microscopic polyangiitisTA825
Vedolizumab for treating chronic refractory pouchitis after surgery for ulcerative colitis (terminated appraisal)TA826
Prostatic urethral temporary implant insertion for lower urinary tract symptoms caused by benign prostatic hyperplasiaIPG737
Removal, preservation and subsequent reimplantation of ovarian tissue to prevent symptoms from the menopauseIPG738
Neuropad for detecting preclinical diabetic peripheral neuropathyMTG38
iTind for lower urinary tract symptoms caused by benign prostatic hyperplasiaMIB306
Colorectal cancer prevention: colonoscopic surveillance in adults with ulcerative colitis, Crohn's disease or adenomasCG118
Melphalan for haematological diseases before allogeneic haematopoietic stem cell transplant (terminated appraisal)TA822
Dexamethasone intravitreal implant for treating diabetic macular oedemaTA824
Self-harm: assessment, management and preventing recurrenceNG225
Self‑harmQS34
Brolucizumab for treating diabetic macular oedemaTA820
Faecal microbiota transplant for recurrent Clostridioides difficile infectionMTG71
iFuse for treating chronic sacroiliac joint painMTG39
Contrast-enhanced spectral mammography for breast cancerMIB304
Differential target multiplexed spinal cord stimulation for chronic lower back and leg painMIB305
Avalglucosidase alfa for treating Pompe diseaseTA821
Focal resurfacing implants to treat articular cartilage damage in the kneeIPG734
Transcutaneous electrical neuromuscular stimulation for urinary incontinenceIPG735
Superficial venous arterialisation for chronic limb threatening ischaemiaIPG736
Sacituzumab govitecan for treating unresectable triple-negative advanced breast cancer after 2 or more therapiesTA819
Nivolumab with ipilimumab for untreated unresectable malignant pleural mesotheliomaTA818
Cefiderocol for treating severe drug-resistant gram-negative bacterial infectionsHTE2
Ceftazidime with avibactam for treating severe drug-resistant gram-negative bacterial infectionsHTE1
Type 1 diabetes in adults: diagnosis and managementNG17
Guselkumab for treating active psoriatic arthritis after inadequate response to DMARDsTA815
Alpelisib with fulvestrant for treating hormone receptor-positive, HER2-negative, PIK3CA-mutated advanced breast cancerTA816
Nivolumab for adjuvant treatment of invasive urothelial cancer at high risk of recurrenceTA817
SecurAcath for securing percutaneous cathetersMTG34
Stockholm3 for prostate cancer screeningMIB303
Pralsetinib for treating RET fusion-positive advanced non-small-cell lung cancerTA812
Asciminib for treating chronic myeloid leukaemia after 2 or more tyrosine kinase inhibitorsTA813
Abrocitinib, tralokinumab or upadacitinib for treating moderate to severe atopic dermatitisTA814
Bioresorbable stent implantation to treat coronary artery diseaseIPG732
Aortic remodelling hybrid stent insertion during surgical repair of an acute type A aortic dissectionIPG733
Duvelisib for treating relapsed or refractory chronic lymphocytic leukaemia after 2 or more treatments (terminated appraisal)TA811
PLGF-based testing to help diagnose suspected preterm pre-eclampsiaDG49
Transcatheter tricuspid valve annuloplasty for tricuspid regurgitationIPG730
Transcatheter tricuspid valve leaflet repair for tricuspid regurgitationIPG731
Melanoma: assessment and managementNG14
Urinary tract infection in under 16s: diagnosis and managementNG224
Urinary tract infection in children and young peopleQS36
Fever in under 5sQS64
Imlifidase for desensitisation treatment before kidney transplant in people with chronic kidney diseaseTA809
Abemaciclib with endocrine therapy for adjuvant treatment of hormone receptor-positive, HER2-negative, node-positive early breast cancer at high risk of recurrenceTA810
PeritX peritoneal catheter drainage system for vacuum-assisted drainage of treatment-resistant, recurrent malignant ascitesMTG9
Risankizumab for treating active psoriatic arthritis after inadequate response to DMARDsTA803
Icosapent ethyl with statin therapy for reducing the risk of cardiovascular events in people with raised triglyceridesTA805
Belimumab for treating lupus nephritis (terminated appraisal)TA806
Roxadustat for treating symptomatic anaemia in chronic kidney diseaseTA807
ProciseDx point-of-care platform for inflammatory bowel diseaseMIB302
Fenfluramine for treating seizures associated with Dravet syndromeTA808
Setmelanotide for treating obesity caused by LEPR or POMC deficiencyHST21
Social, emotional and mental wellbeing in primary and secondary educationNG223
Lenus COPD Support Service for remotely managing chronic obstructive pulmonary diseaseMIB300
Cyanoacrylate glue for hernia mesh fixationMIB301
MiraQ for assessing graft flow during coronary artery bypass graft surgeryMTG8
RespiraSense for continuously monitoring respiratory rateMIB299
Teduglutide for treating short bowel syndromeTA804
Faricimab for treating diabetic macular oedemaTA799
Faricimab for treating wet age-related macular degenerationTA800
Pembrolizumab plus chemotherapy for untreated, triple-negative, locally recurrent unresectable or metastatic breast cancerTA801
Cemiplimab for treating advanced cutaneous squamous cell carcinomaTA802
Vertebral body tethering for idiopathic scoliosis in children and young peopleIPG728
Nerve graft for corneal denervationIPG729
Depression in adults: treatment and managementNG222
Type 2 diabetes in adults: managementNG28
Durvalumab for maintenance treatment of unresectable non-small-cell lung cancer after platinum-based chemoradiationTA798
Multiple sclerosis in adults: managementNG220
Venetoclax for treating chronic lymphocytic leukaemiaTA796
Enfortumab vedotin for previously treated locally advanced or metastatic urothelial cancer (terminated appraisal)TA797
Reducing sexually transmitted infectionsNG221
Preterm labour and birthNG25
Gout: diagnosis and managementNG219
Anifrolumab for treating active autoantibody-positive systemic lupus erythematosus (terminated appraisal)TA793
Diroximel fumarate for treating relapsing–remitting multiple sclerosisTA794
Ibrutinib for treating Waldenstrom's macroglobulinaemiaTA795
Peristeen Plus transanal irrigation system for managing bowel dysfunctionMTG36
Thopaz+ portable digital system for managing chest drainsMTG37
Filgotinib for treating moderately to severely active ulcerative colitisTA792
Synthetic cartilage implant insertion for first metatarsophalangeal joint osteoarthritis (hallux rigidus)IPG727
Social work with adults experiencing complex needsNG216
TYRX Absorbable Antibacterial Envelope for preventing infection from cardiac implantable electronic devices (terminated appraisal)TA790
Romosozumab for treating severe osteoporosisTA791
Endoanchoring systems in endovascular aortic aneurysm repairIPG725
Supercapsular percutaneously assisted total hip arthroplasty for osteoarthritisIPG726
Sleepio to treat insomnia and insomnia symptomsMTG70
Tepotinib for treating advanced non-small-cell lung cancer with MET gene alterationsTA789
Personalised external aortic root support (PEARS) using mesh to prevent aortic root expansion and aortic dissection in people with Marfan syndromeIPG724
Vaccine uptake in the general populationNG218
Vaccine uptake in under 19sQS145
Avelumab for maintenance treatment of locally advanced or metastatic urothelial cancer after platinum-based chemotherapyTA788
Antimicrobial prescribing: oritavancin for acute bacterial skin and skin structure infectionsES39
Antimicrobial prescribing: eravacycline for complicated intra-abdominal infections in adultsES40
ViewSite Brain Access System (VBAS) for the surgical management of deep brain lesionsMIB295
Granulox for managing chronic non-healing woundsMIB296
Selumetinib for treating symptomatic and inoperable plexiform neurofibromas associated with type 1 neurofibromatosis in children aged 3 and overHST20
AMBLor for identifying low-risk non-ulcerated early-stage cutaneous melanomasMIB294
Bladder EpiCheck for detecting bladder cancer recurrenceMIB293
Tucatinib with trastuzumab and capecitabine for treating HER2-positive advanced breast cancer after 2 or more anti-HER2 therapiesTA786
Venetoclax with low dose cytarabine for untreated acute myeloid leukaemia when intensive chemotherapy is unsuitableTA787
Liposuction for chronic lymphoedemaIPG723
Epilepsies in children, young people and adultsNG217
Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancerTA784
Nivolumab with cabozantinib for untreated advanced renal cell carcinoma (terminated appraisal)TA785
Elosulfase alfa for treating mucopolysaccharidosis type 4AHST19
Intramedullary distraction for upper limb lengtheningIPG722
Medicines associated with dependence or withdrawal symptoms: safe prescribing and withdrawal management for adultsNG215
Daratumumab monotherapy for treating relapsed and refractory multiple myelomaTA783
Stroke and transient ischaemic attack in over 16s: diagnosis and initial managementNG128
myCOPD for managing chronic obstructive pulmonary diseaseMTG68
UroShield for preventing catheter-associated urinary tract infectionsMTG69
Diabetes in children and young peopleQS125
Sotorasib for previously treated KRAS G12C mutation-positive advanced non-small-cell lung cancerTA781
Tagraxofusp for treating blastic plasmacytoid dendritic cell neoplasm (terminated appraisal)TA782
Freelite assays for diagnosing multiple myeloma and related conditions (terminated assessment)DG47
Liposuction for chronic lipoedemaIPG721
icobrain ms for active relapsing–remitting multiple sclerosisMIB291
Joint replacement (primary): hip, knee and shoulderQS206
Atidarsagene autotemcel for treating metachromatic leukodystrophyHST18
Nivolumab with ipilimumab for untreated advanced renal cell carcinomaTA780
Neonatal parenteral nutritionQS205
Dostarlimab for previously treated advanced or recurrent endometrial cancer with high microsatellite instability or mismatch repair deficiencyTA779
Integrated health and social care for people experiencing homelessnessNG214
Fetal alcohol spectrum disorderQS204
SecurePort IV tissue adhesive for use with percutaneous cathetersMIB288
Otitis media (acute): antimicrobial prescribingNG91
Lenalidomide for relapsed or refractory mantle cell lymphoma (terminated appraisal)TA774
Empagliflozin for treating chronic heart failure with reduced ejection fractionTA773
Dapagliflozin for treating chronic kidney diseaseTA775
Pitolisant hydrochloride for treating excessive daytime sleepiness caused by obstructive sleep apnoeaTA776
Solriamfetol for treating excessive daytime sleepiness caused by obstructive sleep apnoeaTA777
Pegcetacoplan for treating paroxysmal nocturnal haemoglobinuriaTA778
Percutaneous insertion of a cystic duct stent after cholecystostomy for acute calculous cholecystitisIPG720
Prontosan for treating acute and chronic woundsMTG67
3C Patch for treating diabetic foot ulcersMTG66
Endoscopic full thickness removal of gastrointestinal stromal tumours of the stomachIPG717
Intramedullary distraction for lower limb lengtheningIPG718
Endoscopic balloon dilation for subglottic or tracheal stenosisIPG719
Mental wellbeing at workNG212
Lumella point-of-care test for assessing pre-eclampsia riskMIB287
Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma after stem cell transplant or at least 2 previous therapiesTA772
PredictSURE IBD and IBDX to guide treatment of Crohn's diseaseDG45
EarlyCDT Lung for assessing risk of lung cancer in solid lung nodulesDG46
Odevixibat for treating progressive familial intrahepatic cholestasisHST17
The Insides System for managing intestinal failureMIB286
Pembrolizumab with carboplatin and paclitaxel for untreated metastatic squamous non-small-cell lung cancerTA770
Daratumumab with bortezomib, melphalan and prednisone for untreated multiple myeloma (terminated appraisal)TA771
d-Nav insulin management app for type 2 diabetesMIB285
Olaparib for treating BRCA mutation-positive HER2-negative metastatic breast cancer after chemotherapy (terminated appraisal)TA762
Daratumumab in combination for untreated multiple myeloma when a stem cell transplant is suitableTA763
Fremanezumab for preventing migraineTA764
Venetoclax with azacitidine for untreated acute myeloid leukaemia when intensive chemotherapy is unsuitableTA765
Pembrolizumab for adjuvant treatment of completely resected stage 3 melanomaTA766
Ponesimod for treating relapsing–remitting multiple sclerosisTA767
Upadacitinib for treating active psoriatic arthritis after inadequate response to DMARDsTA768
Palforzia for treating peanut allergy in children and young peopleTA769
Stereotactic radiosurgery for trigeminal neuralgiaIPG715
Microwave ablation for primary or metastatic cancer in the lungIPG716
Colorectal cancerQS20
Sedaconda ACD-S for sedation with volatile anaesthetics in intensive careMTG65
Glaucoma: diagnosis and managementNG81
Sodium zirconium cyclosilicate for treating hyperkalaemiaTA599
Osimertinib for adjuvant treatment of EGFR mutation-positive non-small-cell lung cancer after complete tumour resectionTA761
Rehabilitation after traumatic injuryNG211
Selpercatinib for previously treated RET fusion-positive advanced non-small-cell lung cancerTA760
Smart Peak Flow for monitoring asthmaMIB282
Cabotegravir with rilpivirine for treating HIV-1TA757
Solriamfetol for treating excessive daytime sleepiness caused by narcolepsyTA758
Prostate cancerQS91
Headaches in over 12s: diagnosis and managementCG150
Fedratinib for treating disease-related splenomegaly or symptoms in myelofibrosisTA756
Endo-SPONGE for treating low rectal anastomotic leakMTG63
Belimumab for treating active autoantibody-positive systemic lupus erythematosusTA752
Cenobamate for treating focal onset seizures in epilepsyTA753
Mogamulizumab for previously treated mycosis fungoides and Sézary syndromeTA754
Transanal total mesorectal excision for rectal cancerIPG713
Endobronchial nerve ablation for chronic obstructive pulmonary diseaseIPG714
Colorectal cancerNG151
Prostate cancer: diagnosis and managementNG131
ClearGuard HD antimicrobial barrier caps for preventing haemodialysis catheter-related bloodstream infectionsMTG62
Urinary incontinence in womenQS77
Pelvic floor dysfunction: prevention and non-surgical managementNG210
Olaparib for maintenance treatment of BRCA mutation-positive metastatic pancreatic cancer after platinum-based chemotherapy (terminated appraisal)TA750
Dupilumab for treating severe asthma with type 2 inflammationTA751
FreeO2 automatic oxygen titration for chronic obstructive pulmonary disease and respiratory distress syndromeMIB281
Brain tumours (primary) and brain metastases in over 16sQS203
Mexiletine for treating the symptoms of myotonia in non-dystrophic myotonic disordersTA748
Liraglutide for managing obesity in people aged 12 to 17 years (terminated appraisal)TA749
Synergo for non-muscle-invasive bladder cancerMTG61
CerebAir for continuous EEG monitoring in intensive careMIB279
Paige Prostate for prostate cancerMIB280
clonoSEQ for minimal residual disease assessment in multiple myeloma, acute lymphoblastic leukaemia and chronic lymphocytic leukaemiaMIB278
Fever in under 5s: assessment and initial managementNG143
Givosiran for treating acute hepatic porphyriaHST16
Percutaneous implantation of pulmonary artery pressure sensors for monitoring treatment of chronic heart failureIPG711
Coronary sinus narrowing device implantation for refractory anginaIPG712
Chronic kidney disease: assessment and managementNG203
Nivolumab for adjuvant treatment of resected oesophageal or gastro-oesophageal junction cancerTA746
Nintedanib for treating progressive fibrosing interstitial lung diseasesTA747
SeHCAT (tauroselcholic [75 selenium] acid) for diagnosing bile acid diarrhoeaDG44
Acute heart failure: diagnosis and managementCG187
Heart valve disease presenting in adults: investigation and managementNG208
Upadacitinib for treating moderate rheumatoid arthritisTA744
NBTXR-3 for treating advanced soft tissue sarcoma (terminated appraisal)TA745
Inducing labourNG207
Inducing labourQS60
Selpercatinib for treating advanced thyroid cancer with RET alterationsTA742
24/7 EEG SubQ for epilepsyMIB277
Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and managementNG206
Apalutamide with androgen deprivation therapy for treating high-risk hormone-relapsed non-metastatic prostate cancerTA740
Apalutamide with androgen deprivation therapy for treating hormone-sensitive metastatic prostate cancerTA741
Atezolizumab for untreated PD-L1-positive advanced urothelial cancer when cisplatin is unsuitableTA739
Genicular artery embolisation for pain from knee osteoarthritisIPG708
Laparoscopic renal denervation for loin pain haematuria syndromeIPG709
Percutaneous endovascular forearm arteriovenous fistula creation for haemodialysis accessIPG710
Tofacitinib for treating juvenile idiopathic arthritisTA735
Nivolumab for treating recurrent or metastatic squamous cell carcinoma of the head and neck after platinum-based chemotherapyTA736
Berotralstat for preventing recurrent attacks of hereditary angioedemaTA738
Looked-after children and young peopleNG205
Secukinumab for treating moderate to severe plaque psoriasis in children and young peopleTA734
Baloxavir marboxil for treating acute uncomplicated influenza (terminated appraisal)TA732
Inclisiran for treating primary hypercholesterolaemia or mixed dyslipidaemiaTA733
DyeVert Systems for reducing the risk of acute kidney injury in coronary and peripheral angiographyMTG60
Avapritinib for treating unresectable or metastatic gastrointestinal stromal tumours (terminated appraisal)TA730
Vericiguat for treating chronic heart failure with reduced ejection fraction (terminated appraisal)TA731
Daratumumab with pomalidomide and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)TA726
Isatuximab with carfilzomib and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)TA727
Midostaurin for treating advanced systemic mastocytosisTA728
Sapropterin for treating hyperphenylalaninaemia in phenylketonuriaTA729
Lateral elbow resurfacing for arthritisIPG705
Transapical transcatheter mitral valve-in-valve implantation for a failed surgically implanted mitral valve bioprosthesisIPG706
Transapical transcatheter mitral valve-in-ring implantation after failed annuloplasty for mitral valve repairIPG707
Abemaciclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapyTA725
OrganOx metra for liver transplantMIB275
Carnation Ambulatory Monitor for ambulatory detection of cardiac arrythmiasMIB276
Nivolumab with ipilimumab and chemotherapy for untreated metastatic non-small-cell lung cancerTA724
Workplace health: long-term sickness absence and capability to workQS202
End of life care for adultsQS13
Bimekizumab for treating moderate to severe plaque psoriasisTA723
Colli-Pee for first void urine collectionMIB273
PLASMA system with button electrode for electrovaporisation of the prostateMIB274
Pemigatinib for treating relapsed or refractory advanced cholangiocarcinoma with FGFR2 fusion or rearrangementTA722
Magnetic resonance therapy for knee osteoarthritisIPG702
Laparoscopic removal of uterine fibroids with power morcellationIPG703
Hysteroscopic mechanical tissue removal (hysteroscopic morcellation) for uterine fibroidsIPG704
Babies, children and young people's experience of healthcareNG204
Continuous positive airway pressure for the treatment of obstructive sleep apnoea/hypopnoea syndromeTA139
Obstructive sleep apnoea/hypopnoea syndrome and obesity hypoventilation syndrome in over 16sNG202
Antenatal careNG201
Venous thromboembolism in adultsQS201
Chlormethine gel for treating mycosis fungoides-type cutaneous T-cell lymphomaTA720
Abiraterone for treating newly diagnosed high-risk hormone-sensitive metastatic prostate cancerTA721
Melatonin for treating sleep disorders in adults who are blindES38
Antimicrobial prescribing: delafloxacin for community-acquired pneumoniaES37
MMprofiler for prognostic risk classification in multiple myelomaMIB270
Patient Status Engine for wireless monitoring of vital signsMIB271
Lung texture analysis for measuring interstitial lung diseasesMIB272
Bronchiolitis in children: diagnosis and managementNG9
Immunoscore for predicting risk of colon cancer relapseMIB269
Nivolumab with ipilimumab for previously treated metastatic colorectal cancer with high microsatellite instability or mismatch repair deficiencyTA716
Inducing and maintaining normothermia using temperature modulation devices to improve outcomes after stroke or subarachnoid haemorrhageIPG701
Clostridioides difficile infection: antimicrobial prescribingNG199
Duvelisib for treating relapsed follicular lymphoma after 2 or more systemic therapies (terminated appraisal)TA717
Ixekizumab for treating axial spondyloarthritisTA718
Secukinumab for treating non-radiographic axial spondyloarthritisTA719
ENDURALIFE powered CRT-D devices for treating heart failureMTG33
Dasatinib for treating Philadelphia-chromosome-positive acute lymphoblastic leukaemia (terminated appraisal)TA714
Adalimumab, etanercept, infliximab and abatacept for treating moderate rheumatoid arthritis after conventional DMARDs have failedTA715
HealthVCF for detecting vertebral compression fractures on CT scansMIB267
trublood-prostate for triaging and diagnosing people with prostate cancer symptomsMIB268
Enzalutamide for treating hormone-sensitive metastatic prostate cancerTA712
Nivolumab for advanced non-squamous non-small-cell lung cancer after chemotherapyTA713
AI technologies for detecting diabetic retinopathyMIB265
Acumen IQ sensor for predicting hypotension riskMIB266
Dabigatran etexilate for the prevention of stroke and systemic embolism in atrial fibrillationTA249
Rivaroxaban for the prevention of stroke and systemic embolism in people with atrial fibrillationTA256
Edoxaban for preventing stroke and systemic embolism in people with non-valvular atrial fibrillationTA355
Apixaban for preventing stroke and systemic embolism in people with non-valvular atrial fibrillationTA275
Atrial fibrillation: diagnosis and managementNG196
Plus Sutures for preventing surgical site infectionMTG59
Budesonide orodispersible tablet for inducing remission of eosinophilic oesophagitisTA708
Pembrolizumab for untreated metastatic colorectal cancer with high microsatellite instability or mismatch repair deficiencyTA709
Ravulizumab for treating atypical haemolytic uraemic syndromeTA710
Laser lithotripsy for difficult-to-treat bile duct stonesIPG699
Percutaneous insertion of a closure device to repair a paravalvular leak around a replaced mitral or aortic valveIPG700
Patient experience in adult NHS services: improving the experience of care for people using adult NHS servicesCG138
Shared decision makingNG197
Nivolumab for previously treated unresectable advanced or recurrent oesophageal cancerTA707
SYNE-COV for predicting COVID-19 outcomesMIB264
Autism spectrum disorder in adults: diagnosis and managementCG142
Autism spectrum disorder in under 19s: support and managementCG170
Ozanimod for treating relapsing–remitting multiple sclerosisTA706
Atezolizumab monotherapy for untreated advanced non-small-cell lung cancerTA705
WoundExpress to manage lower leg woundsMIB261
Ibrutinib with obinutuzumab for untreated chronic lymphocytic leukaemia and small lymphocytic lymphoma (terminated appraisal)TA702
Ibrutinib with rituximab for untreated chronic lymphocytic leukaemia (terminated appraisal)TA703
Trastuzumab deruxtecan for treating HER2-positive unresectable or metastatic breast cancer after 2 or more anti-HER2 therapiesTA704
Electrohydraulic lithotripsy for difficult-to-treat bile duct stonesIPG698
Ex-situ machine perfusion for extracorporeal preservation of lungs (ex-vivo lung perfusion) for transplantIPG695
Transvaginal laser therapy for stress urinary incontinenceIPG696
Transvaginal laser therapy for urogenital atrophyIPG697
Heavy menstrual bleeding: assessment and managementNG88
Ravulizumab for treating paroxysmal nocturnal haemoglobinuriaTA698
Ofatumumab for treating relapsing multiple sclerosisTA699
Crisaborole for treating mild to moderate atopic dermatitis in people 2 years and older (terminated appraisal)TA701
HeartFlow FFRCT for estimating fractional flow reserve from coronary CT angiographyMTG32
Parafricta Bootees and Undergarments to reduce skin breakdown in people with or at risk of pressure ulcersMTG20
Andexanet alfa for reversing anticoagulation from apixaban or rivaroxabanTA697
KODEX-EPD for cardiac imaging during ablation of arrhythmiasMIB260
Permanent His-bundle pacemaker implantation for treating heart failureIPG694
UroLift for treating lower urinary tract symptoms of benign prostatic hyperplasiaMTG58
Axonics sacral neuromodulation system for faecal incontinenceMIB259
Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapyTA692
Bempedoic acid with ezetimibe for treating primary hypercholesterolaemia or mixed dyslipidaemiaTA694
Carfilzomib with dexamethasone and lenalidomide for previously treated multiple myelomaTA695
Repetitive short-pulse transscleral cyclophotocoagulation for glaucomaIPG692
Deep brain stimulation for chronic, severe, treatment-resistant obsessive-compulsive disorder in adultsIPG693
Avelumab for treating metastatic Merkel cell carcinomaTA517
Acalabrutinib for treating chronic lymphocytic leukaemiaTA689
Avelumab for untreated metastatic Merkel cell carcinomaTA691
Melphalan chemosaturation with percutaneous hepatic artery perfusion and hepatic vein isolation for primary or metastatic cancer in the liverIPG691
microINR for anticoagulation therapyMIB257
Postnatal careNG194
Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary painNG193
RenalSense Clarity RMS for acute kidney injuryMIB256
Anakinra for treating Still's diseaseTA685
Blinatumomab for previously treated Philadelphia-chromosome-positive acute lymphoblastic leukaemia (terminated appraisal)TA686
Ribociclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapyTA687
Transcervical ultrasound-guided radiofrequency ablation for symptomatic uterine fibroidsIPG689
Extracorporeal whole liver perfusion for acute liver failureIPG690
Danis stent for acute oesophageal variceal bleedingMTG57
Caesarean birthQS32
Sonata system for diagnostic imaging and treatment of symptomatic uterine fibroidsMIB255
Cannabis-based medicinal productsNG144
Asthma: diagnosis, monitoring and chronic asthma managementNG80
Supporting adult carersQS200
Nivolumab for adjuvant treatment of completely resected melanoma with lymph node involvement or metastatic diseaseTA684
QAngio XA 3D QFR and CAAS vFFR imaging software for assessing coronary stenosis during invasive coronary angiographyDG43
Erenumab for preventing migraineTA682
Pembrolizumab with pemetrexed and platinum chemotherapy for untreated, metastatic, non-squamous non-small-cell lung cancerTA683
Alpha-Stim AID for anxiety disordersMTG56
Butterfly iQ+ for diagnostic ultrasound imagingMIB254
Lenalidomide maintenance treatment after an autologous stem cell transplant for newly diagnosed multiple myelomaTA680
Baricitinib for treating moderate to severe atopic dermatitisTA681
Free-functioning gracilis transfer to restore upper limb function in brachial plexus injuryIPG687
Cytoreduction surgery with hyperthermic intraoperative peritoneal chemotherapy for peritoneal carcinomatosisIPG688
Secondary bacterial infection of eczema and other common skin conditions: antimicrobial prescribingNG190
Safeguarding adults in care homesNG189
Filgotinib for treating moderate to severe rheumatoid arthritisTA676
Brexucabtagene autoleucel for treating relapsed or refractory mantle cell lymphomaTA677
Omalizumab for treating chronic rhinosinusitis with nasal polyps (terminated appraisal)TA678
Dapagliflozin for treating chronic heart failure with reduced ejection fractionTA679
Remsima (infliximab biosimilar) for subcutaneous injection for managing Crohn's disease and ulcerative colitisES35
Metreleptin for treating lipodystrophyHST14
Niraparib for maintenance treatment of advanced ovarian, fallopian tube and peritoneal cancer after response to first-line platinum-based chemotherapyTA673
Pembrolizumab for untreated PD-L1-positive, locally advanced or metastatic urothelial cancer when cisplatin is unsuitable (terminated appraisal)TA674
Vernakalant for the rapid conversion of recent onset atrial fibrillation to sinus rhythm (terminated appraisal)TA675
moorLDLS-BI for burn depth assessmentMIB251
The STAK tool for preventing and treating knee stiffnessMIB252
PROPEL sinus implants for maintaining sinus patency after surgeryMIB253
Trabectedin for the treatment of advanced soft tissue sarcomaTA185
URO17 for detecting bladder cancerMIB250
Mepolizumab for treating severe eosinophilic asthmaTA671
Brolucizumab for treating wet age-related macular degenerationTA672
Leukomed Sorbact for preventing surgical site infectionMTG55
DOAC Dipstick for detecting direct oral anticoagulantsMIB248
CytoSorb for reducing risk of bleeding during cardiac surgeryMIB249
Brain tumours (primary) and brain metastases in over 16sNG99
Brigatinib for ALK-positive advanced non-small-cell lung cancer that has not been previously treated with an ALK inhibitorTA670
Self-expanding implant insertion into the intersphincteric space for faecal incontinenceIPG685
Minimally invasive radical hysterectomy for early stage cervical cancerIPG686
The VAC Veraflo Therapy system for acute infected or chronic wounds that are failing to healMTG54
Accuro for guiding epidural or spinal anaesthesiaMIB245
AcQMap for mapping the heart atria to target ablation treatment for arrhythmiasMIB246
Abortion careQS199
Natural Cycles for monitoring fertilityMIB244
Suspected neurological conditions: recognition and referralQS198
Encorafenib plus cetuximab for previously treated BRAF V600E mutation-positive metastatic colorectal cancerTA668
The PLASMA system for transurethral resection and haemostasis of the prostateMTG53
Antimicrobial prescribing: delafloxacin for acute bacterial skin and skin structure infectionsES32
Optilume for anterior urethral stricturesMIB241
Artificial intelligence in mammographyMIB242
Artificial intelligence for analysing chest CT imagesMIB243
Atezolizumab with bevacizumab for treating advanced or unresectable hepatocellular carcinomaTA666
Caplacizumab with plasma exchange and immunosuppression for treating acute acquired thrombotic thrombocytopenic purpuraTA667
PancreatitisNG104
Diabetes in pregnancy: management from preconception to the postnatal periodNG3
Eating disorders: recognition and treatmentNG69
ReStore Soft Exo-Suit for gait rehabilitationMIB239
Cytosponge for detecting abnormal cells in the oesophagusMIB240
Peripheral arterial disease: diagnosis and managementCG147
Low back pain and sciatica in over 16s: assessment and managementNG59
Venetoclax with obinutuzumab for untreated chronic lymphocytic leukaemiaTA663
Liraglutide for managing overweight and obesityTA664
Upadacitinib for treating severe rheumatoid arthritisTA665
Evoke Spinal Cord Stimulator for managing chronic neuropathic or ischaemic painMIB238
Zio XT for detecting cardiac arrhythmiasMTG52
Darolutamide with androgen deprivation therapy for treating hormone-relapsed non-metastatic prostate cancerTA660
Pembrolizumab for untreated metastatic or unresectable recurrent head and neck squamous cell carcinomaTA661
Durvalumab in combination for untreated extensive-stage small-cell lung cancer (terminated appraisal)TA662
QuickChange Incontinence Wrap for urinary incontinence in menMIB237
Drug-eluting stents for the treatment of coronary artery diseaseTA152
Guidance on the use of coronary artery stentsTA71
Siponimod for treating secondary progressive multiple sclerosisTA656
Carfilzomib for previously treated multiple myelomaTA657
Isatuximab with pomalidomide and dexamethasone for treating relapsed and refractory multiple myelomaTA658
Galcanezumab for preventing migraineTA659
Swallowable gastric balloon capsule for weight lossIPG684
Acute coronary syndromesNG185
Acute coronary syndromes in adultsQS68
Magseed for locating impalpable breast cancer lesionsMIB236
NPi-200 for pupillary light reflex in critical care patientsMIB235
Human and animal bites: antimicrobial prescribingNG184
Dexcom G6 for real-time continuous glucose monitoringMIB233
Testing strategies for Lynch syndrome in people with endometrial cancerDG42
Antimicrobial prescribing: imipenem with cilastatin and relebactamES30
Pressurised intraperitoneal aerosol chemotherapy for peritoneal carcinomatosisIPG681
Balloon cryoablation for Barrett's oesophagusIPG682
Balloon cryoablation for squamous dysplasia of the oesophagusIPG683
Tegaderm CHG securement dressing for vascular access sitesMIB231
Nivolumab for advanced squamous non-small-cell lung cancer after chemotherapyTA655
Volanesorsen for treating familial chylomicronaemia syndromeHST13
Heavy menstrual bleedingQS47
Osimertinib for treating EGFR T790M mutation-positive advanced non-small-cell lung cancerTA653
Osimertinib for untreated EGFR mutation-positive non-small-cell lung cancerTA654
SEM Scanner 200 for preventing pressure ulcersMTG51
Rheumatoid arthritis in adults: managementNG100
Behaviour change: digital and mobile health interventionsNG183
Pembrolizumab with axitinib for untreated advanced renal cell carcinomaTA650
Naldemedine for treating opioid-induced constipationTA651
Polatuzumab vedotin with rituximab and bendamustine for treating relapsed or refractory diffuse large B-cell lymphomaTA649
Transcranial magnetic stimulation for auditory hallucinationsIPG680
Novii Wireless Patch System for maternal and fetal monitoringMIB228
Neuropathic pain in adults: pharmacological management in non-specialist settingsCG173
t:slim X2 insulin pump for managing blood glucose levels in type 1 diabetesMIB227
Insect bites and stings: antimicrobial prescribingNG182
Dupilumab for treating chronic rhinosinusitis with nasal polyps (terminated appraisal)TA648
Axonics sacral neuromodulation system for treating refractory overactive bladderMTG50
Glasdegib with chemotherapy for untreated acute myeloid leukaemia (terminated appraisal)TA646
Eculizumab for treating relapsing neuromyelitis optica (terminated appraisal)TA647
Avelumab with axitinib for untreated advanced renal cell carcinomaTA645
Implantable cardiac monitors to detect atrial fibrillation after cryptogenic strokeDG41
Helge for detecting haemolysisMIB225
Community pharmacies: promoting health and wellbeingQS196
Faltering growthQS197
High-sensitivity troponin tests for the early rule out of NSTEMIDG40
FebriDx for C-reactive protein and myxovirus resistance protein A testingMIB224
Anaphylaxis: assessment and referral after emergency treatmentCG134
Perioperative care in adultsNG180
Rehabilitation for adults with complex psychosisNG181
Surgical site infections: prevention and treatmentNG125
Brentuximab vedotin in combination for untreated systemic anaplastic large cell lymphomaTA641
Gilteritinib for treating relapsed or refractory acute myeloid leukaemiaTA642
Entrectinib for treating ROS1-positive advanced non-small-cell lung cancerTA643
Entrectinib for treating NTRK fusion-positive solid tumoursTA644
Deep brain stimulation for refractory epilepsy in adultsIPG678
Implanted vagus nerve stimulation for treatment-resistant depressionIPG679
Healthy.io test for home testing of urine albumin to creatinine ratioMIB221
pCONUS2 Bifurcation Aneurysm Implant for complex intracranial aneurysmsMIB222
Spartan RX point-of-care CYP2C19 test to guide treatment in acute coronary syndromeMIB223
Decision making and mental capacityQS194
Treosulfan with fludarabine for malignant disease before allogeneic stem cell transplantTA640
Transcranial magnetic stimulation for obsessive-compulsive disorderIPG676
Electrical stimulation to improve muscle strength in chronic respiratory conditions, chronic heart failure and chronic kidney diseaseIPG677
Renal and ureteric stonesQS195
Artificial iris insertion for acquired aniridiaIPG674
Artificial iris insertion for congenital aniridiaIPG675
Remsima (infliximab biosimilar) for subcutaneous injection for managing rheumatoid arthritisES29
Specialist neonatal respiratory care for babies born pretermQS193
CFHealthHub for managing cystic fibrosis during the COVID-19 pandemicMIB219
Atezolizumab with carboplatin and etoposide for untreated extensive-stage small-cell lung cancerTA638
Atezolizumab with nab-paclitaxel for untreated PD-L1-positive, locally advanced or metastatic, triple-negative breast cancerTA639
Daratumumab with lenalidomide and dexamethasone for untreated multiple myeloma (terminated appraisal)TA634
Ramucirumab with erlotinib for untreated EGFR-positive metastatic non-small-cell lung cancer (terminated appraisal)TA635
Eculizumab for treating refractory myasthenia gravis (terminated appraisal)TA636
Ranibizumab for treating diabetic retinopathy (terminated appraisal)TA637
Avatrombopag for treating thrombocytopenia in people with chronic liver disease needing a planned invasive procedureTA626
Intravascular lithotripsy for calcified coronary arteries during percutaneous coronary interventionIPG673
Rezum for treating lower urinary tract symptoms secondary to benign prostatic hyperplasiaMTG49
MolecuLight i:X for wound imagingMIB212
Actim Pancreatitis for diagnosing acute pancreatitisMIB218
Ustekinumab for treating moderately to severely active ulcerative colitisTA633
Tests to help assess risk of acute kidney injury for people being considered for critical care admission (ARCHITECT and Alinity i Urine NGAL assays, BioPorto NGAL test and NephroCheck test)DG39
Generalised anxiety disorder and panic disorder in adults: managementCG113
Archimedes for biopsy of suspected lung cancerMIB211
Intravenous fluid therapy in children and young people in hospitalNG29
Trastuzumab emtansine for adjuvant treatment of HER2-positive early breast cancerTA632
Joint replacement (primary): hip, knee and shoulderNG157
Larotrectinib for treating NTRK fusion-positive solid tumoursTA630
Cytokine adsorption devices for treating respiratory failure in people with COVID-19MIB217
Lorlatinib for previously treated ALK-positive advanced non-small-cell lung cancerTA628
Obinutuzumab with bendamustine for treating follicular lymphoma after rituximabTA629
PneuX to prevent ventilator-associated pneumoniaMTG48
Lifelight First for monitoring vital signsMIB213
Lenalidomide with rituximab for previously treated follicular lymphomaTA627
Abdominal aortic aneurysm: diagnosis and managementNG156
Artificial intelligence for analysing CT brain scansMIB207
NATROX oxygen wound therapy for managing diabetic foot ulcers and complex or chronic non-healing woundsMIB208
TUC Safety Valve to prevent balloon inflation in the urethra during transurethral catheterisationMIB210
Tinnitus: assessment and managementNG155
Cor-Knot for tying suture knots in valve surgeryMIB206
Recombinant human parathyroid hormone for treating hypoparathyroidism (terminated appraisal)TA625
Bilateral cervicosacropexy (CESA) or vaginosacropexy (VASA) using mesh for pelvic organ prolapseIPG669
Cyanoacrylate glue occlusion for varicose veinsIPG670
MRI-guided laser interstitial thermal therapy for drug-resistant epilepsyIPG671
Selective internal radiation therapy for unresectable colorectal metastases in the liverIPG672
Intrapartum care: existing medical conditions and obstetric complicationsQS192
Impetigo: antimicrobial prescribingNG153
Neonatal parenteral nutritionNG154
Peginterferon beta-1a for treating relapsing–remitting multiple sclerosisTA624
SepsiTest assay for rapidly identifying bloodstream bacteria and fungiDG20
National Early Warning Score systems that alert to deteriorating adult patients in hospitalMIB205
Patiromer for treating hyperkalaemiaTA623
Sotagliflozin with insulin for treating type 1 diabetesTA622
Antenatal and postnatal mental health: clinical management and service guidanceCG192
Episcissors-60 for mediolateral episiotomyMTG47
Leg ulcer infection: antimicrobial prescribingNG152
Cerebral palsy in adultsQS191
Fetoscopic prenatal repair for open neural tube defects in the fetusIPG667
Open prenatal repair for open neural tube defects in the fetusIPG668
Reducing the risk of transmission of Creutzfeldt–Jakob disease (CJD) from surgical instruments used for interventional procedures on high-risk tissuesIPG666
Supporting adult carersNG150
Virtual Touch Quantification to diagnose and monitor liver fibrosis in chronic hepatitis B and CMTG27
Atezolizumab with carboplatin and nab-paclitaxel for untreated advanced non-squamous non-small-cell lung cancer (terminated appraisal)TA618
Flu vaccination: increasing uptakeQS190
Rheumatoid arthritis in over 16sQS33
Lusutrombopag for treating thrombocytopenia in people with chronic liver disease needing a planned invasive procedureTA617
Indoor air quality at homeNG149
Cannabidiol with clobazam for treating seizures associated with Dravet syndromeTA614
Cannabidiol with clobazam for treating seizures associated with Lennox–Gastaut syndromeTA615
Antimicrobial prescribing: ceftolozane with tazobactam for treating hospital-acquired pneumonia, including ventilator-associated pneumoniaES22
Balloon dilation for chronic eustachian tube dysfunctionIPG665
LQD Spray for treating acute and chronic woundsMIB202
PulmoVista 500 for monitoring ventilation in critical careMIB203
Lung cancer in adultsQS17
eXroid for internal haemorrhoidsMIB201
PIUR tUS for abdominal aortic aneurysm surveillance and endovascular aneurysm repair endoleak detectionMIB200
gammaCore for cluster headacheMTG46
Optowire for measuring fractional flow reserveMIB199
Cerliponase alfa for treating neuronal ceroid lipofuscinosis type 2HST12
Irreversible electroporation for primary liver cancerIPG664
Diverticular disease: diagnosis and managementNG147
AmnioSense for unexplained vaginal wetness in pregnancyMIB198
Neratinib for extended adjuvant treatment of hormone receptor-positive, HER2-positive early stage breast cancer after adjuvant trastuzumabTA612
Antimicrobial prescribing: meropenem with vaborbactamES21
Workplace health: long-term sickness absence and capability to workNG146
Pentosan polysulfate sodium for treating bladder pain syndromeTA610
Point-of-care creatinine devices to assess kidney function before CT imaging with intravenous contrastDG37
Rapid tests for group A streptococcal infections in people with a sore throatDG38
Ibrutinib with rituximab for treating Waldenstrom's macroglobulinaemia (terminated appraisal)TA608
Ramucirumab for treating unresectable hepatocellular carcinoma after sorafenib (terminated appraisal)TA609
Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and managementCG184
Rivaroxaban for preventing atherothrombotic events in people with coronary or peripheral artery diseaseTA607
Lanadelumab for preventing recurrent attacks of hereditary angioedemaTA606
Midcarpal hemiarthroplasty for wrist arthritisIPG663
End of life care for adults: service deliveryNG142
Diabetic foot problems: prevention and managementNG19
superDimension Navigation System to help diagnostic sampling of peripheral lung lesionsMIB194
MR-proADM test for use with clinical deterioration scores in cases of suspected infectionMIB195
Xeomin (botulinum neurotoxin type A) for treating chronic sialorrhoeaTA605
Voretigene neparvovec for treating inherited retinal dystrophies caused by RPE65 gene mutationsHST11
Gastro-oesophageal reflux disease in children and young people: diagnosis and managementNG1
EXOGEN ultrasound bone healing system for long bone fractures with non-union or delayed healingMTG12
Familial hypercholesterolaemia: identification and managementCG71
Idelalisib for treating refractory follicular lymphomaTA604
Cellulitis and erysipelas: antimicrobial prescribingNG141
Lenalidomide with bortezomib and dexamethasone for untreated multiple myeloma (terminated appraisal)TA603
High-intensity focused ultrasound for glaucomaIPG661
Bioprosthetic plug insertion for anal fistulaIPG662
Abortion careNG140
Pomalidomide with bortezomib and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)TA602
Tegaderm CHG securement dressing for vascular access sites in critically ill adultsMTG25
Pneumonia (community-acquired): antimicrobial prescribingNG138
Pneumonia (hospital-acquired): antimicrobial prescribingNG139
Attention deficit hyperactivity disorder: diagnosis and managementNG87
Implant insertion for prominent earsIPG660
InterDry for intertrigoMIB192
Suicide preventionQS189
SuperNO2VA for the relief of upper airway obstruction in people with obstructive sleep apnoeaMIB190
Multiple pregnancy: twin and triplet pregnanciesQS46
Benralizumab for treating severe eosinophilic asthmaTA565
Risankizumab for treating moderate to severe plaque psoriasisTA596
Coexisting severe mental illness and substance misuseQS188
Brentuximab vedotin for untreated advanced Hodgkin lymphoma (terminated appraisal)TA594
Dacomitinib for untreated EGFR mutation-positive non-small-cell lung cancerTA595
Patisiran for treating hereditary transthyretin amyloidosisHST10
Endovascular insertion of an intrasaccular wire-mesh blood-flow disruption device for intracranial aneurysmsIPG658
Low-energy contact X-ray brachytherapy (the Papillon technique) for locally advanced rectal cancerIPG659
Venous thromboembolism in over 16s: reducing the risk of hospital-acquired deep vein thrombosis or pulmonary embolismNG89
Alcohol interventions in secondary and further educationNG135
PICO negative pressure wound dressings for closed surgical incisionsMTG43
Preterm labour and birthQS135
Fluocinolone acetonide intravitreal implant for treating recurrent non-infectious uveitisTA590
Letermovir for preventing cytomegalovirus disease after a stem cell transplantTA591
Patient experience in adult NHS servicesQS15
Service user experience in adult mental health servicesQS14
Chronic obstructive pulmonary disease in over 16s: diagnosis and managementNG115
End of life care for infants, children and young people with life-limiting conditions: planning and managementNG61
Nusinersen for treating spinal muscular atrophyTA588
Blinatumomab for treating acute lymphoblastic leukaemia in remission with minimal residual disease activityTA589
Transurethral laser ablation for recurrent non-muscle-invasive bladder cancerIPG656
Ultrasound-guided high-intensity transcutaneous focused ultrasound for symptomatic uterine fibroidsIPG657
Learning disability: behaviour that challengesQS101
Learning disability: care and support of people growing olderQS187
Motor neurone disease: assessment and managementNG42
Hypertension in pregnancyQS35
HemaClear for bloodless surgical field during limb surgeryMIB187
Therapeutic monitoring of TNF-alpha inhibitors in rheumatoid arthritisDG36
Hearing loss in adultsQS185
Lyme diseaseQS186
Bisphosphonates for treating osteoporosisTA464
Long-acting reversible contraceptionCG30
DementiaQS184
The OPTIMIZER smart system for managing heart failureMIB186
Lenalidomide for treating myelodysplastic syndromes associated with an isolated deletion 5q cytogenetic abnormalityTA322
Lenalidomide for the treatment of multiple myeloma in people who have received at least 2 prior therapiesTA171
Lenalidomide plus dexamethasone for multiple myeloma after 1 treatment with bortezomibTA586
Lenalidomide plus dexamethasone for previously untreated multiple myelomaTA587
Cardiac contractility modulation device implantation for heart failureIPG655
Valve-in-valve TAVI for aortic bioprosthetic valve dysfunctionIPG653
Reinforcement of a permanent stoma with a synthetic or biological mesh to prevent a parastomal herniaIPG654
Depression in children and young people: identification and managementNG134
Urinary incontinence and pelvic organ prolapse in women: managementNG123
Ambu aScope4 Broncho for use in unexpected difficult airwaysMTG14
Ocrelizumab for treating primary progressive multiple sclerosisTA585
Percutaneous insertion of a cerebral protection device to prevent cerebral embolism during TAVIIPG650
Percutaneous mechanical thrombectomy for acute deep vein thrombosis of the legIPG651
Bronchoscopic thermal vapour ablation for upper-lobe emphysemaIPG652
Endocuff Vision for assisting visualisation during colonoscopyMTG45
Physical activity: encouraging activity in the communityQS183
Ertugliflozin with metformin and a dipeptidyl peptidase-4 inhibitor for treating type 2 diabetesTA583
Atezolizumab in combination for treating metastatic non-squamous non-small-cell lung cancerTA584
The Sherlock 3CG Tip Confirmation System for placement of peripherally inserted central cathetersMTG24
Therapeutic hypothermia for acute ischaemic strokeIPG647
Collagen paste for closing an anal fistulaIPG648
Percutaneous mitral valve leaflet repair for mitral regurgitationIPG649
Hyperparathyroidism (primary): diagnosis, assessment and initial managementNG132
Inotersen for treating hereditary transthyretin amyloidosisHST9
Enzalutamide for hormone-relapsed non-metastatic prostate cancerTA580
Curos for preventing infections when using needleless connectorsMTG44
Lead-I ECG devices for detecting symptomatic atrial fibrillation using single time point testing in primary careDG35
DuraGraft for preserving vascular graftsMIB184
Crohn's disease: managementNG129
Ulcerative colitis: managementNG130
Intrapartum care for women with existing medical conditions or obstetric complications and their babiesNG121
Brentuximab vedotin for treating CD30-positive cutaneous T-cell lymphomaTA577
Certolizumab pegol for treating moderate to severe plaque psoriasisTA574
Bosutinib for untreated chronic myeloid leukaemia (terminated appraisal)TA576
Endoscopic ablation for an anal fistulaIPG645
Endoscopic ablation for a pilonidal sinusIPG646
Tildrakizumab for treating moderate to severe plaque psoriasisTA575
ADXBLADDER for detecting bladder cancerMIB180
Specialist neonatal respiratory care for babies born pretermNG124
Narrow band imaging for Barrett's oesophagusMIB179
Ertugliflozin as monotherapy or with metformin for treating type 2 diabetesTA572
The Debrisoft monofilament debridement pad for use in acute or chronic woundsMTG17
Brigatinib for treating ALK-positive advanced non-small-cell lung cancer after crizotinibTA571
Pembrolizumab for treating recurrent or metastatic squamous cell carcinoma of the head and neck after platinum-based chemotherapy (terminated appraisal)TA570
Pertuzumab for adjuvant treatment of HER2-positive early stage breast cancerTA569
Kendall DL for ECG monitoring in people having cardiac surgeryMIB177
Abatacept for treating psoriatic arthritis after DMARDs (terminated appraisal)TA568
Radially emitting laser fibre treatment of an anal fistulaIPG644
Cochlear implants for children and adults with severe to profound deafnessTA566
IQoro for stroke-related dysphagiaMIB175
IQoro for hiatus herniaMIB176
CADScor system for ruling out coronary artery disease in people with symptoms of stable coronary artery diseaseMIB174
Prevena incision management system for closed surgical incisionsMIB173
Air pollution: outdoor air quality and healthQS181
People's experience using adult social care servicesQS182
Venetoclax with rituximab for previously treated chronic lymphocytic leukaemiaTA561
Encorafenib with binimetinib for unresectable or metastatic BRAF V600 mutation-positive melanomaTA562
Abemaciclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancerTA563
High-intensity focused ultrasound for symptomatic benign thyroid nodulesIPG643
Bevacizumab with carboplatin, gemcitabine and paclitaxel for treating the first recurrence of platinum-sensitive advanced ovarian cancer (terminated appraisal)TA560
Barnett Continent Intestinal Reservoir (modified continent ileostomy) to restore continence after colon and rectum removalIPG642
Opioid dependence: buprenorphine prolonged-release injection (Buvidal)ES19
Child abuse and neglectQS179
Serious eye disordersQS180
Axumin for functional imaging of prostate cancer recurrenceMIB172
Cough (acute): antimicrobial prescribingNG120
Sexual healthQS178
StoneChecker for kidney stone evaluationMIB171
Electrically stimulated intravesical chemotherapy for non-muscle-invasive bladder cancerIPG638
Laparoscopic cerclage for cervical incompetence to prevent late miscarriage or preterm birthIPG639
Percutaneous venoplasty for chronic cerebrospinal venous insufficiency in multiple sclerosisIPG640
Path Finder for freezing of gait in people with Parkinson's diseaseMIB170
Platelet-rich plasma injections for knee osteoarthritisIPG637
Senza spinal cord stimulation system for delivering HF10 therapy to treat chronic neuropathic painMTG41
Ex-situ machine perfusion for extracorporeal preservation of livers for transplantationIPG636
RT300 for spinal cord injury rehabilitationMIB169
LiMAx system for assessing the functional capacity of the liverMIB168
Cerebral palsy in adultsNG119
Mepilex Border Heel and Sacrum dressings for preventing pressure ulcersMTG40
Regorafenib for previously treated advanced hepatocellular carcinomaTA555
Darvadstrocel for treating complex perianal fistulas in Crohn's diseaseTA556
Pipeline Flex embolisation device with Shield Technology for the treatment of complex intracranial aneurysmsMTG10
Renal and ureteric stones: assessment and managementNG118
Pancreatic cancerQS177
Lenvatinib for untreated advanced hepatocellular carcinomaTA551
Liposomal cytarabine–daunorubicin for untreated acute myeloid leukaemiaTA552
Transcutaneous neuromuscular electrical stimulation for oropharyngeal dysphagia in adultsIPG634
Bronchial thermoplasty for severe asthmaIPG635
Video laryngoscopes to help intubation in people with difficult airwaysMIB167
Bronchiectasis (non-cystic fibrosis), acute exacerbation: antimicrobial prescribingNG117
Galaxy UNYCO for temporary stabilisation of lower limb fracturesMIB166
Oesophago-gastric cancerQS176
Vandetanib for treating medullary thyroid cancerTA550
Decitabine for untreated acute myeloid leukaemia (terminated appraisal)TA548
Denosumab for preventing skeletal-related events in multiple myeloma (terminated appraisal)TA549
Post-traumatic stress disorderNG116
Chronic obstructive pulmonary disease (acute exacerbation): antimicrobial prescribingNG114
Tofacitinib for moderately to severely active ulcerative colitisTA547
Transcranial MRI-guided focused ultrasound thalamotomy for neuropathic painIPG632
Percutaneous insertion of a temporary heart pump for left ventricular haemodynamic support in high-risk percutaneous coronary interventionsIPG633
Urinary tract infection (catheter-associated): antimicrobial prescribingNG113
Padeliporfin for untreated localised prostate cancerTA546
Gemtuzumab ozogamicin for untreated acute myeloid leukaemiaTA545
Subcutaneous automated low-flow pump implantation for refractory ascites caused by cirrhosisIPG631
Selective internal radiation therapy for unresectable primary intrahepatic cholangiocarcinomaIPG630
Urinary tract infection (lower): antimicrobial prescribingNG109
Prostatitis (acute): antimicrobial prescribingNG110
Pyelonephritis (acute): antimicrobial prescribingNG111
Urinary tract infection (recurrent): antimicrobial prescribingNG112
Eltrombopag for treating chronic immune thrombocytopeniaTA293
Romiplostim for the treatment of chronic immune thrombocytopeniaTA221
Servo-n with Neurally Adjusted Ventilatory Assist (NAVA) for babies and childrenMIB163
Myeloma: diagnosis and managementNG35
Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanomaTA544
Lyme diseaseNG95
Renal replacement therapy services for adultsQS72
Tofacitinib for treating active psoriatic arthritis after inadequate response to DMARDsTA543
Renal replacement therapy and conservative managementNG107
Decision-making and mental capacityNG108
Cabozantinib for untreated advanced renal cell carcinomaTA542
E‑vita open plus for treating complex aneurysms and dissections of the thoracic aortaMTG16
myAIRVO2 for the treatment of chronic obstructive pulmonary diseaseMIB161
OxyMask for delivering oxygen therapyMIB160
Eating disordersQS175
AsthmaQS25
Inotuzumab ozogamicin for treating relapsed or refractory B-cell acute lymphoblastic leukaemiaTA541
Intravesical microwave hyperthermia and chemotherapy for non-muscle-invasive bladder cancerIPG628
The Vest for delivering high-frequency chest wall oscillation in people with complex neurological needsMIB159
Chronic heart failure in adults: diagnosis and managementNG106
Preventing suicide in community and custodial settingsNG105
Emergency and acute medical care in over 16sQS174
Lutetium (177Lu) oxodotreotide for treating unresectable or metastatic neuroendocrine tumoursTA539
Leadless cardiac pacemaker implantation for bradyarrhythmiasIPG626
Superior rectal artery embolisation for haemorrhoidsIPG627
AlignRT in breast cancer radiotherapyMIB157
Neon EEG electrode for EEG monitoring in newbornsMIB155
Dinutuximab beta for treating neuroblastomaTA538
Sutureless aortic valve replacement for aortic stenosisIPG624
Flu vaccination: increasing uptakeNG103
Transurethral water vapour ablation for lower urinary tract symptoms caused by benign prostatic hyperplasiaIPG625
Intermediate care including reablementQS173
Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodineTA535
Alectinib for untreated ALK-positive advanced non-small-cell lung cancerTA536
Ixekizumab for treating active psoriatic arthritis after inadequate response to DMARDsTA537
EndometriosisQS172
Community pharmacies: promoting health and wellbeingNG102
Dupilumab for treating moderate to severe atopic dermatitisTA534
Low-intensity pulsed ultrasound to promote healing of fresh fractures at low risk of non-healingIPG621
Low-intensity pulsed ultrasound to promote healing of fresh fractures at high risk of non-healingIPG622
Low-intensity pulsed ultrasound to promote healing of delayed-union and non-union fracturesIPG623
Mechanical thrombectomy devices for acute ischaemic strokeMIB153
Remote ECG interpretation consultancy services for cardiovascular diseaseMIB152
Ocrelizumab for treating relapsing–remitting multiple sclerosisTA533
Superior capsular augmentation for massive rotator cuff tearsIPG619
Transaxial interbody lumbosacral fusion for severe chronic low back painIPG620
Medicines management for people receiving social care in the communityQS171
Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancerTA531
Airglove air warming system for venous accessMIB151
Crizotinib for treating ROS1-positive advanced non-small-cell lung cancerTA529
Nivolumab for treating locally advanced unresectable or metastatic urothelial cancer after platinum-containing chemotherapyTA530
Biomarker tests to help diagnose preterm labour in women with intact membranesDG33
SpondyloarthritisQS170
Beta interferons and glatiramer acetate for treating multiple sclerosisTA527
Donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's diseaseTA217
Unilateral MRI-guided focused ultrasound thalamotomy for treatment-resistant essential tremorIPG617
Laparoscopic ventral mesh rectopexy for internal rectal prolapseIPG618
Dementia: assessment, management and support for people living with dementia and their carersNG97
ORA G3 to measure corneal hysteresisMIB150
Guselkumab for treating moderate to severe plaque psoriasisTA521
Midostaurin for untreated acute myeloid leukaemiaTA523
Brentuximab vedotin for treating CD30-positive Hodgkin lymphomaTA524
Atezolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapyTA525
Arsenic trioxide for treating acute promyelocytic leukaemiaTA526
Intranasal phototherapy for allergic rhinitisIPG616
Cancer of the upper aerodigestive tract: assessment and management in people aged 16 and overNG36
VIDAvision for lung volume analysis in emphysemaMIB148
Low-level laser therapy for preventing or treating oral mucositis caused by radiotherapy or chemotherapyIPG615
Cystic fibrosisQS168
Developmental follow-up of children and young people born pretermQS169
Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after chemotherapyTA520
AlignRT for intracranial stereotactic radiosurgeryMIB147
Promoting health and preventing premature mortality in black, Asian and other minority ethnic groupsQS167
Percutaneous balloon valvuloplasty for fetal critical aortic stenosisIPG613
Adjunctive colposcopy technologies for assessing suspected cervical abnormalities: the DYSIS colposcope with DYSISmap and the ZedScan IDG32
Robot-assisted kidney transplantIPG609
Prostate artery embolisation for lower urinary tract symptoms caused by benign prostatic hyperplasiaIPG611
Microinvasive subconjunctival insertion of a trans-scleral gelatin stent for primary open-angle glaucomaIPG612
Noctura 400 Sleep Mask for diabetic retinopathy and diabetic macular oedemaMIB144
Nerve transfer to partially restore upper limb function in tetraplegiaIPG610
Tocilizumab for treating giant cell arteritisTA518
ColonFlag for identifying people at risk of colorectal cancerMIB142
Care and support of people growing older with learning disabilitiesNG96
Drug misuse preventionQS165
TraumaQS166
Eribulin for treating locally advanced or metastatic breast cancer after 1 chemotherapy regimenTA515
Cabozantinib for treating medullary thyroid cancerTA516
Learning disabilities and behaviour that challenges: service design and deliveryNG93
Emergency and acute medical care in over 16s: service delivery and organisationNG94
Physical activity and the environmentNG90
Brodalumab for treating moderate to severe plaque psoriasisTA511
Tivozanib for treating advanced renal cell carcinomaTA512
Obinutuzumab for untreated advanced follicular lymphomaTA513
Attention deficit hyperactivity disorderQS39
Mosaicplasty for symptomatic articular cartilage defects of the kneeIPG607
Laparoscopic mesh pectopexy for apical prolapse of the uterus or vaginaIPG608
Autologous chondrocyte implantation using chondrosphere for treating symptomatic articular cartilage defects of the kneeTA508
Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancerTA509
Unilateral MRI-guided focused ultrasound thalamotomy for moderate to severe tremor in Parkinson's diseaseIPG606
Sofosbuvir–velpatasvir–voxilaprevir for treating chronic hepatitis CTA507
People's experience in adult social care services: improving the experience of care and support for people using adult social care servicesNG86
Coban 2 for venous leg ulcersMIB140
Aortic valve reconstruction with processed bovine pericardiumIPG604
Mental health of adults in contact with the criminal justice systemQS163
Parkinson's diseaseQS164
Raloxifene for the primary prevention of osteoporotic fragility fractures in postmenopausal womenTA160
Raloxifene and teriparatide for the secondary prevention of osteoporotic fragility fractures in postmenopausal womenTA161
Strimvelis for treating adenosine deaminase deficiency–severe combined immunodeficiencyHST7
Pancreatic cancer in adults: diagnosis and managementNG85
Atrial fibrillationQS93
Pirfenidone for treating idiopathic pulmonary fibrosisTA504
Intrabeam radiotherapy system for adjuvant treatment of early breast cancerTA501
Ibrutinib for treating relapsed or refractory mantle cell lymphomaTA502
Fulvestrant for untreated locally advanced or metastatic oestrogen-receptor positive breast cancerTA503
EpiFix for chronic woundsMIB139
Minimally invasive percutaneous nephrolitholapaxy medium (MIP-M) for removing kidney stonesMIB138
Sore throat (acute): antimicrobial prescribingNG84
Lenvatinib with everolimus for previously treated advanced renal cell carcinomaTA498
Glecaprevir–pibrentasvir for treating chronic hepatitis CTA499
Ceritinib for untreated ALK-positive non-small-cell lung cancerTA500
Age-related macular degenerationNG82
MammaTyper in vitro diagnostic test for determining breast cancer subtypesMIB135
Plasma EGFR mutation tests for adults with locally advanced or metastatic non-small-cell lung cancerMIB137
TYM smartphone otoscope for imaging and videoing the external ear canal and eardrumMIB134
Golimumab for treating non-radiographic axial spondyloarthritisTA497
Next-generation sequencing panel for solid tumour cancers in childrenMIB133
Palbociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancerTA495
Ribociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancerTA496
Autism spectrum disorder in under 19s: recognition, referral and diagnosisCG128
Endobronchial valve insertion to reduce lung volume in emphysemaIPG600
Transcutaneous microwave ablation for severe primary axillary hyperhidrosisIPG601
Artificial heart implantation as a bridge to transplantation for end-stage refractory biventricular heart failureIPG602
Subcutaneous implantable cardioverter defibrillator insertion for preventing sudden cardiac deathIPG603
Atrial fibrillation and heart valve disease: self-monitoring coagulation status using point-of-care coagulometers (the CoaguChek XS system)DG14
Transvaginal mesh repair of anterior or posterior vaginal wall prolapseIPG599
Naltrexone–bupropion for managing overweight and obesityTA494
Suspected cancerQS124
Point-of-care and home faecal calprotectin tests for monitoring treatment response in inflammatory bowel diseaseMIB132
Vismodegib for treating basal cell carcinomaTA489
Processed nerve allografts to repair peripheral nerve discontinuitiesIPG597
Hypoglossal nerve stimulation for moderate to severe obstructive sleep apnoeaIPG598
Trastuzumab emtansine for treating HER2-positive advanced breast cancer after trastuzumab and a taxaneTA458
Regorafenib for previously treated unresectable or metastatic gastrointestinal stromal tumoursTA488
Tests in secondary care to identify people at high risk of ovarian cancerDG31
Total distal radioulnar joint replacement for symptomatic joint instability or arthritisIPG595
Extracranial to intracranial bypass for intracranial atherosclerosisIPG596
HTG EdgeSeq ALKPlus Assay EU for ALK status testing in non-small-cell lung cancerMIB128
Familial hypercholesterolaemiaQS41
Sarilumab for moderate to severe rheumatoid arthritisTA485
Aflibercept for treating choroidal neovascularisationTA486
Radiation dose monitoring software for medical imaging with ionising radiationMIB127
Sinusitis (acute): antimicrobial prescribingNG79
Cataracts in adults: managementNG77
Cystic fibrosis: diagnosis and managementNG78
Hepatitis B (chronic): diagnosis and managementCG165
PleuraFlow Active Clearance Technology for maintaining chest tube patencyMIB125
Tofacitinib for moderate to severe rheumatoid arthritisTA480
Immunosuppressive therapy for kidney transplant in adultsTA481
Immunosuppressive therapy for kidney transplant in children and young peopleTA482
Cerebral palsy in children and young peopleQS162
Child maltreatment: when to suspect maltreatment in under 18sCG89
Child abuse and neglectNG76
Autologous chondrocyte implantation for treating symptomatic articular cartilage defects of the kneeTA477
Brentuximab vedotin for treating relapsed or refractory systemic anaplastic large cell lymphomaTA478
Reslizumab for treating severe eosinophilic asthmaTA479
Thora-3Di for assessing asthma in childrenMIB122
Memokath-028, 044 and 045 stents for urethral obstructionMIB123
FreeStyle Libre for glucose monitoringMIB110
Intramuscular diaphragm stimulation for ventilator-dependent chronic respiratory failure caused by motor neurone diseaseIPG593
Faltering growth: recognition and management of faltering growth in childrenNG75
Cetuximab and panitumumab for previously untreated metastatic colorectal cancerTA439
Intermediate care including reablementNG74
Caris Molecular Intelligence for guiding cancer treatmentMIB120
Type 2 diabetes: prevention in people at high riskPH38
Aptiva for painful diabetic neuropathyMIB119
Ab externo canaloplasty for primary open-angle glaucomaIPG591
High-intensity focused ultrasound for symptomatic breast fibroadenomaIPG592
Pembrolizumab for advanced melanoma not previously treated with ipilimumabTA366
Pembrolizumab for treating PD-L1-positive non-small-cell lung cancer after chemotherapyTA428
Pembrolizumab for treating advanced melanoma after disease progression with ipilimumabTA357
Transition between inpatient mental health settings and community or care home settingsQS159
End of life care for infants, children and young peopleQS160
Physical health of people in prisonsQS156
HIV testing: encouraging uptakeQS157
Rehabilitation after critical illness in adultsQS158
Sorafenib for treating advanced hepatocellular carcinomaTA474
Dimethyl fumarate for treating moderate to severe plaque psoriasisTA475
Paclitaxel as albumin-bound nanoparticles with gemcitabine for untreated metastatic pancreatic cancerTA476
Fertility problems: assessment and treatmentCG156
Psoriasis: assessment and managementCG153
Cetuximab for treating recurrent or metastatic squamous cell cancer of the head and neckTA473
Fungitell for antifungal treatment stratificationMIB118
Vitamin D: supplement use in specific population groupsPH56
Methylnaltrexone bromide for treating opioid-induced constipation (terminated appraisal)TA468
Idelalisib with ofatumumab for treating chronic lymphocytic leukaemia (terminated appraisal)TA469
Radiofrequency treatment for haemorrhoidsIPG589
Holoclar for treating limbal stem cell deficiency after eye burnsTA467
Advanced breast cancer: diagnosis and treatmentCG81
Pemetrexed for the maintenance treatment of non-small-cell lung cancerTA190
Cabozantinib for previously treated advanced renal cell carcinomaTA463
Baricitinib for moderate to severe rheumatoid arthritisTA466
Biopatch for venous or arterial catheter sitesMIB117
Developmental follow-up of children and young people born pretermNG72
Urethrotech UCD for difficult or failed catheterisationMIB116
moorLDI2-BI: a laser doppler blood flow imager for burn wound assessmentMTG2
Nutrition support for adults: oral nutrition support, enteral tube feeding and parenteral nutritionCG32
VEST external stent for coronary artery bypass graftsMIB115
Chronic kidney disease in adultsQS5
Low back pain and sciatica in over 16sQS155
Adalimumab and dexamethasone for treating non-infectious uveitisTA460
Roflumilast for treating chronic obstructive pulmonary diseaseTA461
Nivolumab for treating relapsed or refractory classical Hodgkin lymphomaTA462
Transcatheter aortic valve implantation for aortic stenosisIPG586
Nasal Alar SpO2 sensor for monitoring oxygen saturation by pulse oximetryMIB113
Parkinson's disease in adultsNG71
Arctic Sun 5000 for therapeutic hypothermia after cardiac arrestMIB112
Constipation in children and young people: diagnosis and managementCG99
Adalimumab, etanercept and ustekinumab for treating plaque psoriasis in children and young peopleTA455
Ustekinumab for moderately to severely active Crohn's disease after previous treatmentTA456
New generation cardiac CT scanners (Aquilion ONE, Brilliance iCT, Discovery CT750 HD and Somatom Definition Flash) for cardiac imaging in people with suspected or known coronary artery disease in whom imaging is difficult with earlier generation CT scannersDG3
Aquilion PRIME CT scanner for imaging coronary artery disease in adults in whom imaging is difficultMIB53
Somatom Definition Edge CT scanner for imaging coronary artery disease in adults in whom imaging is difficultMIB54
Ibrutinib for untreated chronic lymphocytic leukaemia without a 17p deletion or TP53 mutation (terminated appraisal)TA452
Bortezomib for treating multiple myeloma after second or subsequent relapse (terminated appraisal)TA453
Daratumumab with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal)TA454
L-Dex U400 for lymphoedema after breast cancer treatmentMIB111
Air pollution: outdoor air quality and healthNG70
Liver diseaseQS152
MultimorbidityQS153
Violent and aggressive behaviours in people with mental health problemsQS154
Etelcalcetide for treating secondary hyperparathyroidismTA448
Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive diseaseTA449
Blinatumomab for previously treated Philadelphia-chromosome-negative acute lymphoblastic leukaemiaTA450
Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemiaTA451
Eliglustat for treating type 1 Gaucher diseaseHST5
Infracoccygeal sacropexy using mesh to repair vaginal vault prolapseIPG581
Infracoccygeal sacropexy using mesh to repair uterine prolapseIPG582
Sacrocolpopexy using mesh to repair vaginal vault prolapseIPG583
Uterine suspension using mesh (including sacrohysteropexy) to repair uterine prolapseIPG584
Multiple frequency bioimpedance devices to guide fluid management in people with chronic kidney disease having dialysisDG29
RIDASCREEN tests for monitoring infliximab in inflammatory bowel diseaseMIB109
Neo Pedicle Screw System for spinal fusion surgeryMIB108
Oral health in care homesQS151
SecurAcath for securing cerebrospinal fluid cathetersMIB107
Obesity: working with local communitiesPH42
Spondyloarthritis in over 16s: diagnosis and managementNG65
Haematological cancersQS150
Bindex for investigating suspected osteoporosisMIB106
Afatinib for treating advanced squamous non-small-cell lung cancer after platinum-based chemotherapy (terminated appraisal)TA444
Certolizumab pegol and secukinumab for treating active psoriatic arthritis after inadequate response to DMARDsTA445
Endoscopic full thickness removal of non-lifting colonic polypsIPG580
Idiopathic pulmonary fibrosis in adults: diagnosis and managementCG163
Permacol for treating anal fistulaeMIB105
NaviCam for diagnosing gastrointestinal tract conditionsMIB104
Virtual chromoendoscopy to assess colorectal polyps during colonoscopyDG28
Intravenous fluid therapy in adults in hospitalCG174
Irreversible electroporation for treating pancreatic cancerIPG579
Hemosep for cell salvageMIB103
OsteoporosisQS149
Pegylated liposomal irinotecan for treating pancreatic cancer after gemcitabineTA440
Ixekizumab for treating moderate to severe plaque psoriasisTA442
Obeticholic acid for treating primary biliary cholangitisTA443
VAAFT for treating anal fistulaeMIB102
Antisocial behaviour and conduct disorders in children and young people: recognition and managementCG158
Alcohol-use disorders: diagnosis and management of physical complicationsCG100
Sexually transmitted infections: condom distribution schemesNG68
Minimally invasive sacroiliac joint fusion surgery for chronic sacroiliac painIPG578
Irritable bowel syndrome in adults: diagnosis and managementCG61
Managing medicines for adults receiving social care in the communityNG67
Alectinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer (terminated appraisal)TA438
Panitumumab in combination with chemotherapy for the treatment of metastatic colorectal cancer (terminated appraisal)TA240
Mitochondrial disorders in children: Co-enzyme Q10ES11
Mollii suit for spasticityMIB100
Bair Hugger for measuring core temperature during perioperative careMIB99
Patient group directionsMPG2
Bevacizumab for treating EGFR mutation-positive non-small-cell lung cancer (terminated appraisal)TA436
Ibrutinib with bendamustine and rituximab for treating relapsed or refractory chronic lymphocytic leukaemia after systemic therapy (terminated appraisal)TA437
Elotuzumab for previously treated multiple myeloma (terminated appraisal)TA434
Tenofovir alafenamide for treating chronic hepatitis B (terminated appraisal)TA435
Extraurethral (non-circumferential) retropubic adjustable compression devices for stress urinary incontinence in womenIPG576
Sacrocolpopexy with hysterectomy using mesh to repair uterine prolapseIPG577
Hyperhidrosis: oxybutyninES10
Mental health of adults in contact with the criminal justice systemNG66
Narcolepsy with or without cataplexy in adults: pitolisantES8
Skin involvement in systemic sclerosis: rituximabES7
TopClosure Tension Relief System for wound closureMIB97
SimpliCT laser-guided needle placement in interventional radiologyMIB98
Ustekinumab for treating active psoriatic arthritisTA340
Ustekinumab for the treatment of adults with moderate to severe psoriasisTA180
Head and neck cancerQS146
Healthy workplaces: improving employee mental and physical health and wellbeingQS147
Community engagement: improving health and wellbeingQS148
Care of dying adults in the last days of lifeQS144
Intrapartum careQS105
Everolimus for advanced renal cell carcinoma after previous treatmentTA432
Apremilast for treating active psoriatic arthritisTA433
Molecular testing strategies for Lynch syndrome in people with colorectal cancerDG27
Migalastat for treating Fabry diseaseHST4
Lateral interbody fusion in the lumbar spine for low back painIPG574
Trabecular stent bypass microsurgery for open-angle glaucomaIPG575
Drug misuse prevention: targeted interventionsNG64
Healthcare-associated infections: prevention and control in primary and community careCG139
Severe sialorrhoea (drooling) in children and young people with chronic neurological disorders: oral glycopyrronium bromideES5
Smart One for measuring lung functionMIB96
U-Drain for people needing night drainage of urine or dialysis fluidMIB95
MenopauseQS143
HumiGard for preventing inadvertent perioperative hypothermiaMTG31
Osteoporosis: assessing the risk of fragility fractureCG146
eazyplex SuperBug kits for detecting carbapenemase-producing organismsMIB94
Stable anginaQS21
Falls in older peopleQS86
Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutationTA429
Sofosbuvir–velpatasvir for treating chronic hepatitis CTA430
Cerebral palsy in under 25s: assessment and managementNG62
Antimicrobial stewardship: changing risk-related behaviours in the general populationNG63
CentriMag for heart failureMIB92
Ekso exoskeleton for rehabilitation in people with neurological weakness or paralysisMIB93
Boston Keratoprosthesis Type I for corneal blindnessMIB91
Refractory extrapulmonary sarcoidosis: infliximabES4
Pomalidomide for multiple myeloma previously treated with lenalidomide and bortezomibTA427
Smartinhaler for asthmaMIB90
TuberculosisQS141
Learning disability: identifying and managing mental health problemsQS142
Everolimus with exemestane for treating advanced breast cancer after endocrine therapyTA421
Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancerTA422
Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimensTA423
Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancerTA424
Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemiaTA425
Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemiaTA426
Organ donation for transplantation: improving donor identification and consent rates for deceased organ donationCG135
Extracorporeal shockwave therapy for Achilles tendinopathyIPG571
Radiation therapy for early Dupuytren's diseaseIPG573
Pulmonary sarcoidosis: infliximabES2
Blood transfusionQS138
Oral health promotion in the communityQS139
Ticagrelor for preventing atherothrombotic events after myocardial infarctionTA420
Hypothermia: prevention and management in adults having surgeryCG65
Epiduroscopic lumbar discectomy through the sacral hiatus for sciaticaIPG570
XprESS multi sinus dilation system for treating chronic sinusitisMTG30
CORTRAK 2 Enteral Access System for placing nasoenteral feeding tubesMIB48
Mental wellbeing and independence for older peopleQS137
HIV testing: increasing uptake among people who may have undiagnosed HIVNG60
Transition between inpatient hospital settings and community or care home settings for adults with social care needsQS136
Recent-onset chest pain of suspected cardiac origin: assessment and diagnosisCG95
Coexisting severe mental illness and substance misuse: community health and social care servicesNG58
Spasticity in under 19s: managementCG145
OCS Heart system for heart transplantMIB86
CytoSorb therapy for sepsisMIB87
Sternal Talon for sternal closure in cardiothoracic surgeryMIB88
Impella 2.5 for haemodynamic support during high-risk percutaneous coronary interventionsMIB89
Dapagliflozin in combination therapy for treating type 2 diabetesTA288
Nivolumab for previously treated advanced renal cell carcinomaTA417
Dapagliflozin in triple therapy for treating type 2 diabetesTA418
Apremilast for treating moderate to severe plaque psoriasisTA419
Endoscopic transluminal pancreatic necrosectomyIPG567
Percutaneous insertion of craniocaudal expandable implants for vertebral compression fractureIPG568
Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy for treating morbid obesityIPG569
High-throughput non-invasive prenatal testing for fetal RHD genotypeDG25
Minimal change disease and focal segmental glomerulosclerosis in adults: rituximabES1
Physical health of people in prisonNG57
Certolizumab pegol for treating rheumatoid arthritis after inadequate response to a TNF-alpha inhibitorTA415
Elbasvir–grazoprevir for treating chronic hepatitis CTA413
Cobimetinib in combination with vemurafenib for treating unresectable or metastatic BRAF V600 mutation-positive melanomaTA414
Psychosis and schizophrenia in children and young people: recognition and managementCG155
Needle-free arterial non-injectable connectorMIB85
Coeliac diseaseQS134
Single-incision short sling mesh insertion for stress urinary incontinence in womenIPG566
Children's attachmentQS133
Woundchek Protease Status for assessing elevated protease status in chronic woundsMIB83
Necitumumab for untreated advanced or metastatic squamous non-small-cell lung cancerTA411
Radium-223 dichloride for treating hormone-relapsed prostate cancer with bone metastasesTA412
Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancerTA406
Secukinumab for active ankylosing spondylitis after treatment with non-steroidal anti-inflammatory drugs or TNF-alpha inhibitorsTA407
Pegaspargase for treating acute lymphoblastic leukaemiaTA408
Aflibercept for treating visual impairment caused by macular oedema after branch retinal vein occlusionTA409
Talimogene laherparepvec for treating unresectable metastatic melanomaTA410
Miniature lens system implantation for advanced age-related macular degenerationIPG565
Multimorbidity: clinical assessment and managementNG56
Intravenous fluid therapy in children and young people in hospitalQS131
Social care for older people with multiple long-term conditionsQS132
Harmful sexual behaviour among children and young peopleNG55
QuikRead go for C-reactive protein testing in primary careMIB78
FLEXISEQ for osteoarthritisMIB80
Alere Afinion CRP for C-reactive protein testing in primary careMIB81
Mental health problems in people with learning disabilities: prevention, assessment and managementNG54
ContraceptionQS129
Transition between inpatient mental health settings and community or care home settingsNG53
Stable angina: managementCG126
Acute upper gastrointestinal bleeding in over 16s: managementCG141
Bosutinib for previously treated chronic myeloid leukaemiaTA401
Pemetrexed maintenance treatment for non-squamous non-small-cell lung cancer after pemetrexed and cisplatinTA402
Ramucirumab for previously treated locally advanced or metastatic non-small-cell lung cancerTA403
Degarelix for treating advanced hormone-dependent prostate cancerTA404
Trifluridine–tipiracil for previously treated metastatic colorectal cancerTA405
Cabazitaxel for hormone-relapsed metastatic prostate cancer treated with docetaxelTA391
Axxent electronic brachytherapy system for early stage breast cancerMIB76
OSNA for colon cancer stagingMIB77
Early years: promoting health and wellbeing in under 5sQS128
Obesity: clinical assessment and managementQS127
Palliative care for adults: strong opioids for pain reliefCG140
Abiraterone for castration-resistant metastatic prostate cancer previously treated with a docetaxel-containing regimenTA259
Azacitidine for treating acute myeloid leukaemia with more than 30% bone marrow blastsTA399
Nivolumab in combination with ipilimumab for treating advanced melanomaTA400
Abiraterone for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicatedTA387
Percutaneous endoscopic laser balloon pulmonary vein isolation for atrial fibrillationIPG563
Motor neurone diseaseQS126
QTUG for assessing falls risk and frailtyMIB73
Stretta System for gastro-oesophageal reflux diseaseMIB74
Non-Hodgkin's lymphoma: diagnosis and managementNG52
Alair bronchial thermoplasty system for adults with severe difficult to control asthmaMIB71
Prophylaxis against infective endocarditis: antimicrobial prophylaxis against infective endocarditis in adults and children undergoing interventional proceduresCG64
Non-alcoholic fatty liver disease (NAFLD): assessment and managementNG49
Oral health for adults in care homesNG48

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