Alteplase for treating acute ischaemic stroke

  • Technology appraisal guidance
  • TA264
  • Published: 
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8 Sources of evidence considered by the Committee

The Evidence Review Group (ERG) report for this appraisal was prepared by the School of Health and Related Research (ScHARR), The University of Sheffield:

  • Davis S, Holmes M, Simpson E et al. Alteplase for the treatment of acute ischaemic stroke (review of technology appraisal 122), May 2012

The following organisations accepted the invitation to participate in this appraisal as consultees and commentators. They were invited to comment on the draft scope. Manufacturers or sponsors were also invited to make written submissions. Professional or specialist, and patient or carer groups gave their expert views on alteplase by providing a written statement to the Committee. Manufacturers or sponsors, professional or specialist, patient or carer groups, and other consultees, also have the opportunity to appeal against the final appraisal determination.

Manufacturers or sponsors:

  • Boehringer Ingelheim

Professional or specialist, and patient or carer groups:

  • AntiCoagulation Europe UK

  • Association of British Neurologists

  • British Geriatrics Society

  • College of Emergency Medicine

  • Royal College of Nursing

  • Royal College of Physicians

Other consultees:

  • Department of Health

  • Welsh Government

Commentator organisations (did not provide written evidence and without the right of appeal):

  • Healthcare Improvement Scotland

  • Medical Research Council

The following individuals were selected from clinical specialist and patient expert nominations from the non-manufacturer or sponsor consultees and commentators. They gave their expert personal view on alteplase by providing oral evidence to the Committee.

  • Professor John Potter, Professor of Ageing and Stroke, University of East Anglia, nominated by the British Geriatric Society – clinical specialist

  • Professor Peter Sandercock, Professor of Medical Neurology, Western General Hospital, nominated by the Association of British Neurologists – clinical specialist

  • Dr Gavin Young, Consultant Neurologist, South Tees NHS Foundation Trust, nominated by the NICE Clinical Guidelines – clinical specialist

  • Joanie Scott, nominated by the Stroke Association – patient expert

  • Robert Yexley, nominated by the Stroke Association – patient expert

Representatives from the following manufacturer or sponsor attended Committee Meetings. They contributed only when asked by the Committee chair to clarify specific issues and comment on factual accuracy.

  • Boehringer Ingelheim

ISBN: 978-1-4731-6720-9