3.1
The manufacturer submitted evidence of clinical and cost effectiveness for ranibizumab compared with verteporfin photodynamic therapy (vPDT) in people with choroidal neovascularisation associated with pathological myopia. Pathological myopia is a chronic condition characterised by excessive lengthening of the eye and degenerative changes at the back of the eye. These changes to the eye can cause blood vessels to leak or bleed into the retina in a process known as choroidal neovascularisation. This can result in visual impairment, in particular a loss of central vision. The manufacturer did not provide a comparison with bevacizumab, which is listed as a comparator in the scope for this appraisal. It did not consider bevacizumab to be a valid comparator because it is unlicensed for this condition and not routinely used.