Please be advised that the format of evaluation reports shared on the NICE website has recently changed, for ease of user navigation between individual documents contained in the report.

It is a requirement of the new (PDF portfolio) format that Adobe Reader is used to view the document. Please follow the link at the bottom of this page to download Adobe Reader if required.

If you have any feedback on the new format please contact the Project Manager for this appraisal.

Colorectal cancer (metastatic) - aflibercept: evaluation report

1 - Pre-Meeting Briefing

2 - Manufacturer submission from Sanofi

3 - NICE request to the manufacturer for clarification on their submission

4 - Manufacturer clarification response

5 - Expert personal perspective from Dr Richard Adams, clinical expert nominated by Sanofi

6 - Expert personal perspective from Helen Minnery, patient expert nominated by Beating Bowel Cancer

7 - Expert personal perspective from Jacqueline Fraser, patient expert nominated by Beating Bowel Cancer

8 - Evidence Review Group report prepared by York Reviews and Implementation Group

9 - Evidence Review Group report – factual accuracy check

10 - Evidence Review Group report - Erratum