Selpercatinib for previously treated RET fusion-positive advanced non-small-cell lung cancer

2.1 Selpercatinib (Retsevmo, Eli Lilly) has a conditional marketing authorisation 'for the treatment of adults with advanced RET fusion-positive non-small-cell lung cancer (NSCLC) who require systemic therapy following prior treatment with immunotherapy and/or platinum-based chemotherapy'.

2.2 The dosage schedule is available in the summary of product characteristics.

2.3 The list price for 60 capsules of selpercatinib (80 mg) is £4,680 (excluding VAT; BNF online, accessed July 2021). The company's estimated cost for a 28‑day cycle of selpercatinib is £8,736.00.

2.4 The company has a commercial arrangement. This makes selpercatinib available to the NHS with a discount. The size of the discount is commercial in confidence. It is the company's responsibility to let relevant NHS organisations know details of the discount.