Tixagevimab plus cilgavimab for preventing COVID-19

4.1 The committee acknowledged the need for tix–cil to be evaluated quickly against all new variants. It also suggested that the company enter tix–cil into ongoing platform trials. This would create a real-time link between in vitro and in vivo data.

4.2 The committee noted the lack of evidence on how the availability of a preventative treatment would affect shielding behaviours, and subsequently affect treatment efficacy. It also noted a lack of data on the relationship between perceived efficacy and direct utility gain. It considered that further research into these areas would be useful.