Draft guidance recognises potential of new targeted treatment for type of advanced breast cancer
NICE has today (26 September 2023) published draft guidance for public consultation that does not recommend trastuzumab deruxtecan for treating advanced HER2-low breast cancer in adults.
NICE’s independent appraisal committee has asked the company for more information ahead of its next meeting. This includes further analyses looking at how much benefit trastuzumab brings for people’s length of life, more evidence that the benefit of treatment continues even when the disease becomes worse and more analyses looking at the outcomes that people experience on standard care given in the NHS.
Some breast cancer cells have a protein called human epidermal growth factor receptor 2 (HER2) on their surface, which stimulates them to grow. HER2‑low is a newly classified subgroup of breast cancer previously considered HER2‑negative.
People with HER2‑low breast cancer that can’t be removed surgically or that has spread to other parts of the body (called unresectable or metastatic breast cancer) have tumours with low amounts of HER2. They are offered treatments for HER2-negative cancer (usually chemotherapy). But, after chemotherapy, people with HER2‑low cancer may be able to have targeted treatments.
Trastuzumab deruxtecan (also called Enhertu and made by Daiichi Sankyo) is the first licensed targeted treatment for this type of breast cancer.
It is estimated that around 1,000 people would have been eligible for treatment with trastuzumab deruxtecan if NICE had recommended it.