Recommendation ID
NG191/12
Question

In people with suspected COVID-19-associated pulmonary aspergillosis (CAPA), what are the most accurate tests for diagnosing the infection and when should they be done?

Any explanatory notes
(if applicable)

Population: adults, young people and children who are critically ill and have, or have had, COVID-19 as part of their acute illness, and suspected CAPA. Subgroups of particular interest include young people and children, and pregnant women.


Diagnostic tests:
• any methods used to diagnose pulmonary aspergillosis (for example, CT imaging, testing of bronchoalveolar lavage, non-bronchoscopic lavage, endotracheal aspirate, sputum samples, serum assays)


Reference standard:
• lung biopsy or postmortem diagnosis


Target condition:
• CAPA


Outcomes:
• sensitivity and specificity
• positive and negative likelihood ratios


Analysis:
• optimal time of diagnostic testing


Source guidance details

Comes from guidance
COVID-19 rapid guideline: managing COVID-19
Number
NG191
Date issued
March 2021

Other details

Is this a recommendation for the use of a technology only in the context of research? No  
Is it a recommendation that suggests collection of data or the establishment of a register?   No  
Last Reviewed 17/12/2021