Individual research recommendation details

Recommendation ID

IPG560/1

Question

NICE encourages further data collection, including randomised controlled trials on microstructural scaffold insertion without autologous cell implantation for repairing symptomatic chondral knee defects. Studies should clearly describe patient selection, clinical indications and adjunctive treatments. Outcome measures should include symptom relief, functional ability, long-term outcomes measured by appropriate imaging techniques and patient-reported outcomes.

Any explanatory notes
(if applicable)

The evidence on microstructural scaffold insertion without autologous cell implantation for repairing symptomatic chondral knee defects raises no major safety concerns; however, current evidence on its efficacy is inadequate in both quality and quantity. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research.

Source guidance details

Comes from guidance

Microstructural scaffold (patch) insertion without autologous cell implantation for repairing symptomatic chondral knee defects

Number

IPG560

Date issued

June 2016

Other details