Individual research recommendation details

Recommendation ID

CG155/3

Question

What is the clinical and cost effectiveness for family intervention combined with individual CBT in the treatment of children and young people considered to be at high risk of developing psychosis and their parents or carers?

Any explanatory notes
(if applicable)

The suggested programme of research would need to test out, using an adequately powered, multicentre, randomised controlled design, the likely benefits and costs of providing family intervention, combined with individual CBT, for children and young people at high risk of developing psychosis and their parents or carers. The outcomes considered should include transition to psychosis, quality of life, symptomatic and functional improvements, treatment acceptability and self-harm. There should be follow-up at 3 years. The trial should also estimate the cost effectiveness of intervening.
Why this is important:- A number of interventions have been trialled in an attempt to avert the development of psychosis, including drugs, psychological interventions and other interventions. After the first episode of psychosis, family intervention as an adjunct to antipsychotic medication substantially and significantly reduces relapse rates. A single small trial combining CBT family treatment with individual CBT without antipsychotic treatment suggested an important reduction in transition rates to the first psychosis.

Source guidance details

Comes from guidance

Psychosis and schizophrenia in children and young people: recognition and management

Number

CG155

Date issued

January 2013

Other details