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Showing 6016 to 6030 of 7682 results

  1. NICE recommended further research to explore the impact of having experiences of patients having continuous infusion 5-FU and take into account the impact on quality of life. The potential consequences of introducing pharmacokinetic dose adjustment should also be explored.

    Recommendation ID DG16/4 Question NICE recommended further research to explore the impact of having experiences of patients having continuous

    Research recommendation
    Published
    9 June 2015

  2. NICE noted advice from clinical experts that there is variability between the faecal immunochemical tests. This may affect the number of positive and negative results reported by the tests when a single threshold is used. It recommended further research to investigate the variability between technologies and encouraged the companies to make sure that results can be standardised for use in a symptomatic population.

    Recommendation ID DG30/2 Question NICE noted advice from clinical experts that there is variability between the faecal immunochemical tests

    Research recommendation
    Published
    15 October 2018

  3. NICE recommended that clinical data, including genotype and sustained virological response at 12 weeks, are collected for all people having treatment with simeprevir in the NHS.

    Recommendation ID TA333/1 Question NICE recommended that clinical data, including genotype and sustained virological response at 12 weeks

    Research recommendation
    Published
    9 June 2015

  4. NICE recommended that clinical data, including genotype and sustained virological response at 12 weeks, is collected for all people treated with sofosbuvir in the NHS.

    Recommendation ID TA330/1 Question NICE recommended that clinical data, including genotype and sustained virological response at 12 weeks

    Research recommendation
    Published
    9 June 2015

  5. NICE recommended that data on the effect of BCM – Body Composition Monitor-guided monitoring on health-related quality of life is collected and published. Prospective within-patient studies, which record quality of life and symptoms before and after having BCM – Body Composition Monitor-guided fluid management should be considered.

    Recommendation ID DG29/2 Question NICE recommended that data on the effect of BCM – Body Composition Monitor-guided monitoring on health-related

    Research recommendation
    Published
    12 October 2018

  6. NICE recommended that further research should be designed to generate robust evidence of the clinical- and cost-effectiveness of Holoclar for treating both eyes in people with bilateral limbal stem cell deficiency after eye burns if they do not have enough tissue for a conjunctival limbal autograft. The study should recruit people with bilateral disease and evaluate the effectiveness of treatment in both eyes. Outcomes should include transplant success and assessments of health-related quality of life using a generic preference-based measure.

    Recommendation ID TA467/2 Question NICE recommended that further research should be designed to generate robust evidence of the clinical-

    Research recommendation
    Published
    15 October 2018

  7. NICE recommended that research should be carried out to determine the relationship between activity and prosthesis failure.

    Recommendation ID TA304/1 Question NICE recommended that research should be carried out to determine the relationship between activity

    Research recommendation
    Published
    9 June 2015

  8. NICE recommended the collection of data on prosthesis failure or on the prevalence of people living with a failed hip but for whom revision surgery is not suitable or who choose not to have revision surgery. NICE further recommended that nomenclature for hip replacement failure needs to be established to allow demarcation of prosthesis-dependent and prosthesisindependent hip replacement failure. Furthermore, patient reported outcome measures collected as part of the National Joint Registry should allow for reporting of hip replacement failure in people who cannot or choose not to have revision surgery.

    Recommendation ID TA304/2 Question NICE recommended the collection of data on prosthesis failure or on the prevalence of people living

    Research recommendation
    Published
    9 June 2015

  9. NICE recommends further research comparing the clinical effectiveness of all 3 viscoelastometric devices (ROTEM, TEG and Sonoclot systems) in cardiac surgery and in the emergency control of bleeding after trauma and during postpartum haemorrhage. In particular, NICE recommends research to determine which of the parameters included in the viscoelastometric testing systems are the most significant in changing clinical decision-making and improving clinical outcomes. The degree of change needed in these parameters to affect clinical decision-making and clinical outcomes should also be considered.

    Recommendation ID DG13/3 Question NICE recommends further research comparing the clinical effectiveness of all 3 viscoelastometric devices

    Research recommendation
    Published
    9 June 2015

  10. NICE recommends further research in using viscoelastometric testing in the emergency control of bleeding after trauma and during postpartum haemorrhage to assess its effectiveness compared with standard laboratory testing. NICE recommends that outcomes should include, but may not be limited to, bleeding outcomes, mortality, duration of hospital or intensive care unit stay, transfusion rates and volumes transfused.

    Recommendation ID DG13/2 Question NICE recommends further research in using viscoelastometric testing in the emergency control of bleeding

    Research recommendation
    Published
    9 June 2015

  11. NICE recommends further research to better inform future cost-effectiveness models of relapsing-remitting multiple sclerosis. In particular, this research should include a more comprehensive synthesis of available evidence on the underlying disease progression of multiple sclerosis in the UK context, the impact of disability and relapses on preference-based measures of quality of life, and associated resource use and costs.

    Recommendation ID TA320/1 Question NICE recommends further research to better inform future cost-effectiveness models of relapsing-remitting

    Research recommendation
    Published
    9 June 2015

  12. NICE recommends further research to demonstrate the utility of the Sonoclot system in detecting, managing and monitoring haemostasis in cardiac surgery.

    Recommendation ID DG13/1 Question NICE recommends further research to demonstrate the utility of the Sonoclot system in detecting, managing

    Research recommendation
    Published
    9 June 2015

  13. NICE recommends further research to establish optimal target dose ranges for 5-FU plasma levels in people with head and neck cancer, stomach cancer and pancreatic cancer.

    Recommendation ID DG16/3 Question NICE recommends further research to establish optimal target dose ranges for 5-FU plasma levels in people

    Research recommendation
    Published
    9 June 2015

  14. NICE recommends further research to investigate the clinical effectiveness of the integrated sensor-augmented insulin pump therapy systems in younger children and pregnant women. No data are currently available for these subgroups and their inclusion in future studies is encouraged.

    Recommendation ID DG21/2 Question NICE recommends further research to investigate the clinical effectiveness of the integrated sensor-augmented

    Research recommendation
    Published
    11 April 2016

  15. NICE recommends further research to quantify the impact of hypoglycaemia on quality of life for people with type 1 diabetes and their carers.Future research should include adults and children and should capture the impact of persistent anxiety associated with the fear of catastrophic events related to severe hypoglycaemic events.

    Recommendation ID DG21/1 Question NICE recommends further research to quantify the impact of hypoglycaemia on quality of life for people

    Research recommendation
    Published
    11 April 2016