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Showing 5686 to 5700 of 7679 results

  1. Unknown primary of presumed upper aerodigestive tract origin:- In people with CUADT of unknown primary, can radiotherapy target volumes be selected based on clinical and pathological factors?

    Recommendation ID NG36/3 Question Unknown primary of presumed upper aerodigestive tract origin:- In people with CUADT of unknown primary

    Research recommendation
    Published
    6 April 2016

  2. Few women use contraception perfectly (that is, exactly in accordance with the product instructions) and consistently. Pregnancy rates during typical use reflect effectiveness of a method among women who use the method incorrectly or inconsistently. Few data are available on typical use of any contraceptive method among women in the UK. Much of the data on contraceptive effectiveness used in the guideline come from clinical trials or surveys undertaken in other countries such as the USA. Large prospective cohort studies are needed to compare the contraceptive effectiveness of LARC methods with non‑LARC methods during typical use in the UK.

    Recommendation ID CG30/1 Question Few women use contraception perfectly (that is, exactly in accordance with the product instructions)

    Research recommendation
    Published
    25 October 2019

  3. Diagnosis: The GDG recommends that a UK study of the performance characteristics and cost-effectiveness of procalcitonin versus C-reactive protein in identifying serious bacterial infection in children with fever without apparent source be carried out.

    Recommendation ID NG143/03 Question Diagnosis: The GDG recommends that a UK study of the performance characteristics and cost-effectiveness

    Research recommendation
    Published
    17 December 2021

  4. Management according to risk of serious illness: The GDG recommends that research is carried out on referral patterns between primary and secondary care for children with fever, so the health economic impact of this and future guidelines can be estimated.

    Recommendation ID NG143/07 Question Management according to risk of serious illness: The GDG recommends that research is carried out on

    Research recommendation
    Published
    17 December 2021

  5. The evidence on transvaginal laser therapy for stress urinary incontinence does not show any short-term safety concerns. Evidence on long-term safety andefficacy is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means onthe NICE interventional procedures guidance page.

    Recommendation ID IPG696/1 Question The evidence on transvaginal laser therapy for stress urinary incontinence does not show any short-term

    Research recommendation
    Published
    10 August 2021

  6. The evidence on transvaginal laser therapy for urogenital atrophy does not show any short-term safety concerns. Evidence on long-term safety and efficacy is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    Recommendation ID IPG697/1 Question The evidence on transvaginal laser therapy for urogenital atrophy does not show any short-term safety

    Research recommendation
    Published
    10 August 2021

  7. Antipyretics: The GDG recommends that studies are conducted in primary care and secondary care to determine whether examination or re-examination after a dose of antipyretic medication is of benefit in differentiating children with serious illness from those with other conditions.

    Recommendation ID NG143/04 Question Antipyretics: The GDG recommends that studies are conducted in primary care and secondary care to determine

    Research recommendation
    Published
    17 December 2021

  8. The experience of consenting for organ donation:- Does a positive experience of approach and process of consent for families increase consent rates?

    Recommendation ID CG135/5 Question The experience of consenting for organ donation:- Does a positive experience of approach and process

    Research recommendation
    Published
    9 June 2015

  9. Symptoms and signs of serious illness: The Guideline Development Group (GDG) recommends a UK-based epidemiological study on the symptoms and signs of serious illness.

    Recommendation ID NG143/01 Question Symptoms and signs of serious illness: The Guideline Development Group (GDG) recommends a UK-based

    Research recommendation
    Published
    17 December 2021

  10. The health-related quality-of-life evidence of patients with perianal fistulas is also lacking, therefore further research is recommended. Any research should measure the effect of treatment using preference-based measures (such as use of the EQ-5D questionnaire).

    Recommendation ID TA556/2 Question The health-related quality-of-life evidence of patients with perianal fistulas is also lacking, therefore

    Research recommendation
    Published
    19 March 2019

  11. The physical health benefits of discontinuing antipsychotic medication:- What are the short- and long-term benefits to physical health of guided medication discontinuation and/or reduction in first episode psychosis and can this be achieved without major risks?

    Recommendation ID CG178/3 Question The physical health benefits of discontinuing antipsychotic medication:- What are the short- and long-term

    Research recommendation
    Published
    9 June 2015

  12. There have been no head-to-head trials of rivaroxaban compared with a low molecular weight heparin for people who have cancer and experience an acute pulmonary embolism or deep vein thrombosis. As in NICE technology appraisal guidance 261 it is recommended that further research should be carried out.

    Recommendation ID TA287/1 Question There have been no head-to-head trials of rivaroxaban compared with a low molecular weight heparin for

    Research recommendation
    Published
    9 June 2015

  13. There is a need for additional research on the management of bleeds that occur while people are receiving apixaban, rivaroxaban or dabigatran etexilate, as there are no antidotes or established treatments to stop active bleeding for these agents.

    Recommendation ID TA275/1 Question There is a need for additional research on the management of bleeds that occur while people are receiving

    Research recommendation
    Published
    9 June 2015

  14. There is a need for further evidence on the long-term outcomes of treatment with eculizumab, and on the effect of treatment in children, adolescents and during pregnancy. The Committee supports enrolment of patients into the aHUS registry and the collection of high-quality information from these registries periodically to inform treatment decisions.

    Recommendation ID HST1/2 Question There is a need for further evidence on the long-term outcomes of treatment with eculizumab, and on the

    Research recommendation
    Published
    9 June 2015

  15. What is the clinical and cost effectiveness of prednisolone, budesonide, and beclometasone in addition to aminosalicylates compared with each other and with aminosalicylate monotherapy for the induction of remission for people with mild-to-moderate ulcerative colitis?

    Recommendation ID NG130/3 Question What is the clinical and cost effectiveness of prednisolone, budesonide, and beclometasone in addition

    Research recommendation
    Published
    25 October 2019