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Showing 5806 to 5820 of 7682 results

  1. Research on second-line treatments for transitional cell carcinoma of the urothelial tract is needed. It noted that the vinflunine studies were the only studies in patients with transitional cell carcinoma of the urothelial tract whose disease had progressed after platinum-based chemotherapy. It was noted that there is a lack of evidence for the relative effectiveness of treatment options at this stage in the pathway of care. It is recommended that studies be undertaken to investigate the relative safety and efficacy of second-line treatments for transitional cell carcinoma of the urothelial tract, particularly randomised controlled trials.

    Recommendation ID TA272/1 Question Research on second-line treatments for transitional cell carcinoma of the urothelial tract is needed

    Research recommendation
    Published
    9 June 2015

  2. Research on the safety and efficacy of superior capsular augmentation for massive rotator cuff tears should address patient selection, type of graft and technique used,long-term outcomes including shoulder function, and patient-reported outcome measures.

    Recommendation ID IPG619/1 Question Research on the safety and efficacy of superior capsular augmentation for massive rotator cuff tears

    Research recommendation
    Published
    19 December 2018

  3. Research should be carried out to compare the clinical effectiveness of bendamustine with chlorambucil at the higher dose used in the Chronic Lymphocytic Leukaemia Trial 4 (CLL4).

    Recommendation ID TA216/1 Question Research should be carried out to compare the clinical effectiveness of bendamustine with chlorambucil

    Research recommendation
    Published
    9 June 2015

  4. How often should people with diabetic foot problems (foot ulcers, soft tissue infections, osteomyelitis or gangrene) be reviewed?

    Recommendation ID NG19/8 Question How often should people with diabetic foot problems (foot ulcers, soft tissue infections, osteomyelitis

    Research recommendation
    Published
    18 November 2019

  5. What clinical features and laboratory investigations can be used to better stratify risk for women in labour with signs of sepsis (including fever and tachycardia)?

    Recommendation ID NG121/4 Question What clinical features and laboratory investigations can be used to better stratify risk for women in

    Research recommendation
    Published
    16 August 2019

  6. Risk assessment in neonates, infants, children and young people:- Which pressure ulcer tools are most effective for predicting pressure ulcer risk in children?

    Recommendation ID CG179/3 Question Risk assessment in neonates, infants, children and young people:- Which pressure ulcer tools are most

    Research recommendation
    Published
    9 June 2015

  7. What are the risk factors for diverticulosis progressing to diverticular disease?

    Recommendation ID NG147/6 Question What are the risk factors for diverticulosis progressing to diverticular disease? Any explanatory

    Research recommendation
    Published
    10 February 2020

  8. What are the risks that predict the development of blood-borne virus infections in people with complex psychosis in the UK?

    Recommendation ID NG181/11 Question What are the risks that predict the development of blood-borne virus infections in people with complex

    Research recommendation
    Published
    26 October 2020

  9. Can risk of contrast-induced acute kidney injury be stratified by eGFR thresholds?

    Recommendation ID NG148/1 Question Can risk of contrast-induced acute kidney injury be stratified by eGFR thresholds? Any explanatory

    Research recommendation
    Published
    10 February 2020

  10. Risk tools to identify risk of developing COAG and risk of sight loss:- What is the predictive value of risk tools for identifying people in the community who are atincreased risk of developing chronic open angle glaucoma (COAG) and identifying people with COAG who are at increased risk of sight loss?

    Recommendation ID NG81/1 Question Risk tools to identify risk of developing COAG and risk of sight loss:- What is the predictive value

    Research recommendation
    Published
    18 October 2018

  11. Robust evidence is needed on the comparative performance of different faecal calprotectin tests, including the performance of POCTs compared with laboratory-based tests.

    Recommendation ID DG11/3 Question Robust evidence is needed on the comparative performance of different faecal calprotectin tests, including

    Research recommendation
    Published
    9 June 2015

  12. What is the effectiveness and cost effectiveness of routinely performing contrast-enhanced brain CT at the time of initial diagnosis and/or staging CT?

    Recommendation ID NG122/3 Question What is the effectiveness and cost effectiveness of routinely performing contrast-enhanced brain CT

    Research recommendation
    Published
    21 June 2019

  13. Routine outcome measurement:- In people with a common mental health disorder, what is the clinical utility of routine outcome measurement and is it cost effective compared with standard care?

    Recommendation ID CG123/4 Question Routine outcome measurement:- In people with a common mental health disorder, what is the clinical utility

    Research recommendation
    Published
    9 June 2015

  14. Safety and efficacy of antimuscarinics:- What is the safety and efficacy of more recently developed antimuscarinics compared with (a) placebo/usual care and (b) other antimuscarinics in the treatment of neurogenic lower urinary tract dysfunction?

    Recommendation ID CG148/1 Question Safety and efficacy of antimuscarinics:- What is the safety and efficacy of more recently developed

    Research recommendation
    Published
    9 June 2015

  15. Safety and efficacy of botulinum toxin:- What is the safety and efficacy of botulinum toxin compared with (a) usual care, (b) antimuscarinics and (c) augmentation cystoplasty in people with neurogenic lower urinary tract dysfunction?

    Recommendation ID CG148/2 Question Safety and efficacy of botulinum toxin:- What is the safety and efficacy of botulinum toxin compared

    Research recommendation
    Published
    9 June 2015