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Showing 4261 to 4275 of 7691 results

  1. A high-quality test accuracy study is needed for the BRAHMS sFlt‑1 Kryptor/BRAHMS PLGF plus Kryptor PE ratio test, using thresholds defined by the company, done in a population independent from that used to establish the test's thresholds, and with the test used as intended in the NHS. Further research is recommended on repeat PLGF (placental growth factor)‑based testing, with standard clinical assessment, in women presenting with suspected preterm pre-eclampsia, who have had a previous PLGF‑based test result (see section 3.7 ). This should include: - exploring the different scenarios in which repeat testing may be indicated - the appropriate intervals between PLGF‑based tests - the diagnostic accuracy of repeat PLGF‑based testing in women with suspected preterm pre-eclampsia. Further research is recommended into how well the tests work when women are pregnant with more than 1 baby to find out if different cut-offs are needed (see section 3.15 ).

    Recommendation ID DG49/01 Question A high-quality test accuracy study is needed for the BRAHMS sFlt‑1 Kryptor/BRAHMS PLGF plus Kryptor

    Research recommendation
    Published
    4 August 2022

  2. What is the minimum air exchange rate to minimise the health effects of poor indoor air quality in the home?

    Recommendation ID NG149/3 Question What is the minimum air exchange rate to minimise the health effects of poor indoor air quality in the

    Research recommendation
    Published
    10 February 2020

  3. Airway clearance techniques:- How effective are daily airway clearance techniques in maintaining lung function in infants and children with cystic fibrosis?

    Recommendation ID NG78/2 Question Airway clearance techniques:- How effective are daily airway clearance techniques in maintaining lung

    Research recommendation
    Published
    6 November 2018

  4. Allogeneic stem cell transplantation:- What is the effectiveness of combined autologous–allogeneic stem cell transplantation compared with autologous stem cell transplantation, plus consolidation and maintenance treatment in chemosensitive patients at first response or first relapse?

    Recommendation ID NG35/4 Question Allogeneic stem cell transplantation:- What is the effectiveness of combined autologous–allogeneic stem

    Research recommendation
    Published
    5 April 2016

  5. Additional research could help address uncertainties in the evidence, although the case for cost savings remains unlikely. Although the committee acknowledged that the Game et al. (2018) RCT was well conducted, it felt that additional research could help resolve some uncertainties around the cost and clinical case for 3C Patch. Specifically, research identifying the most appropriate stopping rule, and the associated clinical outcomes of implementing the rule, would help address key uncertainties within the cost case. Additional collection of resource use data on unhealed hard-to-heal ulcers could also reduce uncertainty in the cost case. Further to this, evidence could be collected on an UrgoStart-experienced population, as this would be reflective of current NHS care. Clinical experts thought a trial on this population would be feasible. The committee concluded that although further research could be done, on balance it was unlikely to result in a cost-saving case for 3C Patch based on the decision problem evaluated in this guidance

    Recommendation ID MTG66/01 Question Additional research could help address uncertainties in the evidence, although the case for cost savings

    Research recommendation
    Published
    8 April 2022

  6. The effects of stopping and/or switching drug treatments to control blood glucose levels: In adults with type 2 diabetes, what are the effects of stopping and/or switching drug treatments to control blood glucose levels, and what criteria should inform the decision?

    Recommendation ID NG28/01 Question The effects of stopping and/or switching drug treatments to control blood glucose levels: In adults

    Research recommendation
    Published
    16 December 2021

  7. Inhibitors of functional ability:- What are the greatest inhibitors of functional ability in children and young people with upper motor neurone lesions?

    Recommendation ID CG145/1 Question Inhibitors of functional ability:- What are the greatest inhibitors of functional ability in children

    Research recommendation
    Published
    9 June 2015

  8. What is the clinical and cost effectiveness of delivering rehabilitation for 7 days a week compared to 5 days a week for people after a stroke?

    Recommendation ID NG236/1 Question What is the clinical and cost effectiveness of delivering rehabilitation for 7 days a week compared

    Research recommendation
    Published
    11 January 2024

  9. Long-term outcomes associated with blood glucose lowering agents: In adults with type 2 diabetes, what are the long‑term effects of blood glucose lowering therapies such as dipeptidyl peptidase‑4 (DPP‑4) inhibitors, sodium–glucose cotransporter‑2 (SGLT2) inhibitors and meglitinides?

    Recommendation ID NG28/04 Question Long-term outcomes associated with blood glucose lowering agents: In adults with type 2 diabetes, what

    Research recommendation
    Published
    16 December 2021

  10. Investigations for proteinuria: In children and young people, what is the accuracy of reagent strips for detecting albumin in urine?

    Recommendation ID NG203/7 Question Investigations for proteinuria: In children and young people, what is the accuracy of reagent strips

    Research recommendation
    Published
    30 September 2021

  11. In infants, children and young people with overt or occult reflux, is fundoplication effective in reducing acid reflux as determined by oesophageal pH monitoring?

    Recommendation ID NG1/3 Question In infants, children and young people with overt or occult reflux, is fundoplication effective in reducing

    Research recommendation
    Published
    9 June 2015

  12. Involving older people in developing interventions:- In the UK, what are the most effective ways of involving older people in developing interventions to promote their independence and mental wellbeing?

    Recommendation ID NG32/4 Question Involving older people in developing interventions:- In the UK, what are the most effective ways of involving

    Research recommendation
    Published
    25 January 2016

  13. Non-metformin-based drug treatment combinations to control blood glucose levels: In adults with type 2 diabetes, what treatment combinations (for example, glucagon‑like peptide‑1 [GLP‑1] mimetics and insulin combination therapy with meglitinides) are most effective when initial drug treatment with non‑metformin monotherapy fails to adequately control blood glucose levels?

    Recommendation ID NG28/02 Question Non-metformin-based drug treatment combinations to control blood glucose levels: In adults with type

    Research recommendation
    Published
    16 December 2021

  14. Does intensive monitoring of people at risk of diabetic foot disease reduce the morbidity associated with developing the disease and is such monitoring cost effective?

    Recommendation ID NG19/1 Question Does intensive monitoring of people at risk of diabetic foot disease reduce the morbidity associated

    Research recommendation
    Published
    15 November 2019

  15. Mandibular advancement splints for mild symptomatic OSAHS and moderate OSAHS: In mild symptomatic OSAHS, which clinical and physiological phenotypes predict treatment response to customised mandibular advancement splints?

    Recommendation ID NG202/4 Question Mandibular advancement splints for mild symptomatic OSAHS and moderate OSAHS: In mild symptomatic OSAHS

    Research recommendation
    Published
    30 September 2021