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Guidance programme

Advice programme

Showing 4981 to 4995 of 7688 results

  1. NICE agreed that further research would be of value to investigate factors which can predict the likelihood of rapid progression of disease and response to treatment with biological DMARDs. Factors to investigate include:- persistent elevation of inflammatory markers (such as C-reactive protein [CRP]) and- presence of erosions on X-ray and- positive for anti-citrullinated protein antibodies (ACPA).

    Recommendation ID TA375/1 Question NICE agreed that further research would be of value to investigate factors which can predict the likelihood

    Research recommendation
    Published
    15 March 2016

  2. More research or data collection is recommended on Sleepio for people who are eligible for face-to-face cognitive behavioural therapy for insomnia (CBT-I) in primary care. This is because there is limited clinical evidence to show how effective Sleepio is compared with face-to-face CBT-I. A real-world study is suggested to compare the effectiveness of Sleepio with face-to-face CBT-I.

    Recommendation ID MTG70/01 Question More research or data collection is recommended on Sleepio for people who are eligible for face-to-face

    Research recommendation
    Published
    31 May 2022

  3. NICE considered that more research is needed to establish the treatment sequence for vemurafenib and ipilimumab in patients who have BRAF V600 mutation-positive melanoma.

    Recommendation ID TA319/1 Question NICE considered that more research is needed to establish the treatment sequence for vemurafenib and

    Research recommendation
    Published
    9 June 2015

  4. Natural history of progression to colorectal cancer in people at increased risk:- What is the natural history of progression to colorectal cancer in people with inflammatory bowel disease (IBD) or adenomas?

    Recommendation ID CG118/2 Question Natural history of progression to colorectal cancer in people at increased risk:- What is the natural

    Research recommendation
    Published
    9 June 2015

  5. NICE encourages further research into insertion of a collagen plug to close an abdominal wall enterocutaneous fistula. Research should ideally take the formof prospective studies that compare the course of the enterocutaneous fistula (its natural history) with and without use of the procedure. Reports should record the conditions underlying all fistulas that are treated, their location, whether they are high or low output, and details of previous treatments. NICE may update the guidance on publication of further evidence.

    Recommendation ID IPG507/1 Question NICE encourages further research into insertion of a collagen plug to close an abdominal wall enterocutaneous

    Research recommendation
    Published
    9 June 2015

  6. NICE considered that there is an important need for head-to-head comparisons between biological treatments for psoriatic arthritis, particularly in people for whom treatment with tumour necrosis factor (TNF) alpha inhibitors has been unsuccessful.

    Recommendation ID TA340/1 Question NICE considered that there is an important need for head-to-head comparisons between biological treatments

    Research recommendation
    Published
    5 October 2015

  7. What is the natural history of people with a Likert score on MRI of less than 3 without biopsy at long-term follow‑up?

    Recommendation ID NG131/5 Question What is the natural history of people with a Likert score on MRI of less than 3 without biopsy at long-term

    Research recommendation
    Published
    25 October 2019

  8. NICE discussed the potential for future research. NICE accepted that there is a need to further establish the accuracy of current practice in diagnosing asthma and the incremental accuracy associated with the addition of FeNO testing.

    Recommendation ID DG12/1 Question NICE discussed the potential for future research. NICE accepted that there is a need to further establish

    Research recommendation
    Published
    9 June 2015

  9. More trials of apixaban compared with other low molecular weight heparin (LMWHs) in total hip and knee replacement would decrease the uncertainty of the clinical and cost effectiveness of these treatments. Trials directly comparing apixaban with rivaroxaban, dabigatran etexilate and fondaparinux would strengthen the evidence base for these comparisons.

    Recommendation ID TA245/1 Question More trials of apixaban compared with other low molecular weight heparin (LMWHs) in total hip and knee

    Research recommendation
    Published
    9 June 2015

  10. NICE encourages further research into intravesical microwave hyperthermia and chemotherapy for non-muscle-invasive bladder cancer. Research should include randomised controlled trials, which stratify patients by risk and give adequate follow-up. They should report frequency of adverse events, patientreported outcome measures, overall and disease-free survival and quality of life.

    Recommendation ID IPG628/1 Question NICE encourages further research into intravesical microwave hyperthermia and chemotherapy for non-muscle-invasive

    Research recommendation
    Published
    12 December 2018

  11. Natural history of varicose veins:- In people with varicose veins at CEAP (Clinical, etiological, anatomical and pathophysiological) stage C2 or C3, what are the factors that influence progression of the disease to CEAP stages C5 or C6?

    Recommendation ID CG168/1 Question Natural history of varicose veins:- In people with varicose veins at CEAP (Clinical, etiological, anatomical

    Research recommendation
    Published
    9 June 2015

  12. NICE encourages clinicians to enter patients into research studies with the particular aims of guiding selection of patients and of defining the place of percutaneous balloon cryoablation in relation to other procedures for treating atrial fibrillation. Further research should define patient selection criteria clearly and should document adverse events and long-term control of atrial fibrillation.

    Recommendation ID IPG427/1 Question NICE encourages clinicians to enter patients into research studies with the particular aims of guiding

    Research recommendation
    Published
    9 June 2015

  13. Morphine compared with ketamine for first-line management of pain:- Is morphine clinically and cost effective compared with ketamine for first-line pharmacological pain management (in both pre-hospital and hospital settings) in patients with major trauma?

    Recommendation ID NG39/3 Question Morphine compared with ketamine for first-line management of pain:- Is morphine clinically and cost effective

    Research recommendation
    Published
    21 March 2016

  14. Does the use of ultrasound of the lumbar spine improve siting of regional anaesthetic needles in pregnant women with a BMI over 30 kg/m 2   at the booking appointment?

    Recommendation ID NG121/2 Question Does the use of ultrasound of the lumbar spine improve siting of regional anaesthetic needles in pregnant

    Research recommendation
    Published
    16 August 2019

  15. NICE encourages further data collection, including randomised controlled trials on microstructural scaffold insertion without autologous cell implantation for repairing symptomatic chondral knee defects. Studies should clearly describe patient selection, clinical indications and adjunctive treatments. Outcome measures should include symptom relief, functional ability, long-term outcomes measured by appropriate imaging techniques and patient-reported outcomes.

    Recommendation ID IPG560/1 Question NICE encourages further data collection, including randomised controlled trials on microstructural

    Research recommendation
    Published
    9 August 2016