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Guidance programme

Advice programme

Showing 5671 to 5685 of 7682 results

  1. For people with active, drug susceptible TB who experience treatment interruptions because of adverse events, particularly hepatotoxicity, what approach to re-establishing treatment is mosteffective in reducing mortality and morbidity?

    Recommendation ID NG33/5 Question For people with active, drug susceptible TB who experience treatment interruptions because of adverse

    Research recommendation
    Published
    8 November 2019

  2. Treatment of convulsive status epilepticus (that is, not just refractory): What is the most effective and safest AED to treat: established (usually lasting longer than 30 minutes) convulsive status epilepticus refractory convulsive status epilepticus?

    Recommendation ID CG137/4 Question Treatment of convulsive status epilepticus (that is, not just refractory): What is the most effective

    Research recommendation
    Published
    13 August 2021

  3. Treatment of torus fractures:- What is the clinical effectiveness and cost effectiveness of no treatment for torus fractures of the distal radius in children compared with soft splints, removable splints or bandages?

    Recommendation ID NG38/5 Question Treatment of torus fractures:- What is the clinical effectiveness and cost effectiveness of no treatment

    Research recommendation
    Published
    21 March 2016

  4. What is the most effective first-line treatment option for any severity of acne vulgaris for people with polycystic ovary syndrome?

    Recommendation ID NG198/2 Question What is the most effective first-line treatment option for any severity of acne vulgaris for people

    Research recommendation
    Published
    3 May 2024

  5. In people with suspected TB, what is the relative clinical and cost effectiveness of universal andrisk-based use of rapid nucleic acid amplification tests?

    Recommendation ID NG33/1 Question In people with suspected TB, what is the relative clinical and cost effectiveness of universal andrisk-based

    Research recommendation
    Published
    8 November 2019

  6. Trials that evaluate utility values (using generic preference-based measures) in children and young people with severe psoriasis are needed to better inform future cost–utility analyses.

    Recommendation ID TA455/1 Question Trials that evaluate utility values (using generic preference-based measures) in children and young

    Research recommendation
    Published
    15 October 2018

  7. How effective and cost effective are universal, education-based alcohol interventions for children and young people aged 11 to 25 with SEND?

    Recommendation ID NG135/3 Question How effective and cost effective are universal, education-based alcohol interventions for children and

    Research recommendation
    Published
    25 October 2019

  8. Truncal treatment with or without concurrent tributary treatment:- What is the clinical and cost effectiveness of concurrent phlebectomies or foam sclerotherapy for varicose tributaries during truncal endothermal ablation for varicose veins compared with: - truncal endothermal ablation without concurrent phlebectomies or foam sclerotherapy? - truncal endothermal ablation with phlebectomies or foam sclerotherapy, if needed, 6–12 weeks later?

    Recommendation ID CG168/4 Question Truncal treatment with or without concurrent tributary treatment:- What is the clinical and cost effectiveness

    Research recommendation
    Published
    9 June 2015

  9. Unknown primary of presumed upper aerodigestive tract origin:- In people with CUADT of unknown primary, can radiotherapy target volumes be selected based on clinical and pathological factors?

    Recommendation ID NG36/3 Question Unknown primary of presumed upper aerodigestive tract origin:- In people with CUADT of unknown primary

    Research recommendation
    Published
    6 April 2016

  10. Few women use contraception perfectly (that is, exactly in accordance with the product instructions) and consistently. Pregnancy rates during typical use reflect effectiveness of a method among women who use the method incorrectly or inconsistently. Few data are available on typical use of any contraceptive method among women in the UK. Much of the data on contraceptive effectiveness used in the guideline come from clinical trials or surveys undertaken in other countries such as the USA. Large prospective cohort studies are needed to compare the contraceptive effectiveness of LARC methods with non‑LARC methods during typical use in the UK.

    Recommendation ID CG30/1 Question Few women use contraception perfectly (that is, exactly in accordance with the product instructions)

    Research recommendation
    Published
    25 October 2019

  11. In addition to individual circumstances and needs, a woman's choice and acceptance of LARC may be influenced by potential health disbenefits (side effects and risks) as well as non‑contraceptive benefits of LARC (such as alleviation of menorrhagia). Large population studies of appropriate design are needed to determine the effect of these factors on the uptake of LARC methods and the implications for NHS resources.

    Recommendation ID CG30/3 Question In addition to individual circumstances and needs, a woman's choice and acceptance of LARC may be influenced

    Research recommendation
    Published
    25 October 2019

  12. Current evidence on the safety of ultrasound-guided high‑intensity transcutaneous focused ultrasound for symptomatic uterine fibroids shows there are well-recognised complications including skin burns. The evidence on efficacy is limited in quality. Therefore, this procedure should only be used with  special arrangements   for clinical governance, consent, and audit or research.

    Recommendation ID IPG657/1 Question Current evidence on the safety of ultrasound-guided high‑intensity transcutaneous focused ultrasound

    Research recommendation
    Published
    15 November 2019

  13. Use of a simple algorithm compared with a standard clinical assessment:- For people with a common mental health disorder, is the use of a simple algorithm (based on factors associated with treatment response), when compared with a standard clinical assessment, more clinically and cost effective?

    Recommendation ID CG123/5 Question Use of a simple algorithm compared with a standard clinical assessment:- For people with a common mental

    Research recommendation
    Published
    9 June 2015

  14. Use of biomarkers to diagnose and initiate treatment:- What is the clinical and cost effectiveness of procalcitonin (PCT) point-of-care tests at initial triage for diagnosis of serious infection and the initiation of appropriate antibiotic therapy?

    Recommendation ID NG51/3 Question Use of biomarkers to diagnose and initiate treatment:- What is the clinical and cost effectiveness of

    Research recommendation
    Published
    25 August 2016

  15. Use of low-molecular-weight heparin to treat patients with an acute painful sickle cell episode:- Are therapeutic doses of low-molecular-weight heparin (LMWH) effective, compared with prophylactic doses of LMWH, in reducing the length of stay in hospital of patients with an acute painful sickle cell episode?

    Recommendation ID CG143/2 Question Use of low-molecular-weight heparin to treat patients with an acute painful sickle cell episode:- Are

    Research recommendation
    Published
    9 June 2015